Diagnostic Advances
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Sep 26, 2016; 6(3): 181-186
Published online Sep 26, 2016. doi: 10.5662/wjm.v6.i3.181
CD4-positive diffuse large B-cell lymphoma: A variant with aggressive clinical potential
Mohammad O Hussaini, Friederike H Kreisel, Anjum Hassan, TuDung T Nguyen, John L Frater
Mohammad O Hussaini, Division of Molecular Pathology, Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, United States
Friederike H Kreisel, Anjum Hassan, TuDung T Nguyen, John L Frater, Division of Hematopathology, Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, United States
Author contributions: All the authors contribute to the paper.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: John L Frater, MD, Division of Hematopathology, Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, United States. jfrater@wustl.edu
Telephone: +1-314-3621553 Fax: +1-314-7474392
Received: April 12, 2016
Peer-review started: April 13, 2016
First decision: May 19, 2016
Revised: June 25, 2016
Accepted: July 29, 2016
Article in press: July 31, 2016
Published online: September 26, 2016
Processing time: 163 Days and 11.5 Hours
Core Tip

Core tip: Aberrant expression of T-cell antigens including CD4 in ALK-negative diffuse large B-cell lymphoma (DLBCL) is a rare phenomenon that raises interesting biological and diagnostic considerations. With regards to our series of DLBCLs expressing CD4, it appears that at least a subset may behave aggressively based on our data.