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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Mar 26, 2016; 6(1): 118-125
Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.118
Published online Mar 26, 2016. doi: 10.5662/wjm.v6.i1.118
Profile and determinants of unsuccessful tuberculosis outcome in rural Nigeria: Implications for tuberculosis control
Kingsley N Ukwaja, Department of Internal Medicine, Federal Teaching Hospital, Abakaliki 480281, Ebonyi State, Nigeria
Sarah N Oshi, Daniel C Oshi, Centre for Development and Reproductive Health, Enugu 400001, Enugu State, Nigeria
Isaac Alobu, National Tuberculosis and Leprosy Control Programme, Ministry of Health, Abakaliki 480001, Ebonyi State, Nigeria
Author contributions: Ukwaja KN, Oshi SN, Alobu I and Oshi DC designed the research; Ukwaja KN, Oshi SN, Alobu I and Oshi DC performed the research; Ukwaja KN and Oshi DC analyzed the data; Ukwaja KN, Oshi SN, Alobu I and Oshi DC wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Ethics and Research Advisory Committee of the National Tuberculosis Control Programme, Ministry of Health, Ebonyi State, Nigeria.
Informed consent statement: As this was a retrospective study, the consent of the patients was not obtained, however, patient records was anonymized and de-identified prior to analysis.
Conflict-of-interest statement: The authors confirm that there are no conflict-of-interests to declare.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at ukwajakingsley@yahoo.co.uk.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Kingsley N Ukwaja, MD, MWACP, Department of Internal Medicine, Federal Teaching Hospital, No 1 FMC Rd, Abakaliki 480281, Ebonyi State, Nigeria. ukwajakingsley@yahoo.co.uk
Telephone: +234-803-6243196
Received: August 29, 2015
Peer-review started: September 5, 2015
First decision: October 27, 2015
Revised: November 23, 2015
Accepted: January 5, 2016
Article in press: January 7, 2016
Published online: March 26, 2016
Processing time: 201 Days and 13.4 Hours
Peer-review started: September 5, 2015
First decision: October 27, 2015
Revised: November 23, 2015
Accepted: January 5, 2016
Article in press: January 7, 2016
Published online: March 26, 2016
Processing time: 201 Days and 13.4 Hours
Core Tip
Core tip: Of 1180 tuberculosis (TB) patients enrolled, overall treatment success rate was 893 (75.7%). Also, death, default, and treatment failure rates were 10.9%, 8.5%, and 1.5%, respectively. Treatment success rate were significantly higher among all human immunodeficiency virus (HIV)-negative TB cases (79.3% vs 60.9%; P < 0.001). The difference was due to higher death rates among HIV-infected TB patients. Predictors of unsuccessful outcomes were; public facility-care, smear-negative or extrapulmonary TB, HIV co-infection, and receiving the 8-mo regimen.