Daugule I, Zavoronkova J, Santare D. Helicobacter pylori and allergy: Update of research. World J Methodol 2015; 5(4): 203-211 [PMID: 26713280 DOI: 10.5662/wjm.v5.i4.203]
Corresponding Author of This Article
Ilva Daugule, MD PhD, Faculty of Medicine, University of Latvia, Raina bulvaris 19, LV1586 Riga, Latvia. ilva_daugule@hotmail.com
Research Domain of This Article
Methodology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ilva Daugule, Jelizaveta Zavoronkova, Daiga Santare, Faculty of Medicine, University of Latvia, LV1586 Riga, Latvia
Author contributions: Daugule I conceived and designed the review, made data analysis and interpretation and wrote the paper; Zavoronkova J made data acquisition and classification; Santare D drafted the article, and made critical revisions.
Conflict-of-interest statement: There is no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ilva Daugule, MD PhD, Faculty of Medicine, University of Latvia, Raina bulvaris 19, LV1586 Riga, Latvia. ilva_daugule@hotmail.com
Telephone: +371-26-320374 Fax: +371-67-034369
Received: May 11, 2015 Peer-review started: May 12, 2015 First decision: June 18, 2015 Revised: September 18, 2015 Accepted: October 16, 2015 Article in press: October 19, 2015 Published online: December 26, 2015
Core Tip
Core tip: Review summarizes research data about the association between Helicobacter pylori (H. pylori) and allergic diseases. Results from observational studies support a weak inverse association between prevalence of H. pylori and allergy. However, different confounders like unidentified socioeconomic factors, antibiotic use and others could bias the observed association. Further, no definite proof for causal relationship has been clearly demonstrated yet, although data from cohort studies point to a possible association of H. pylori with some of the allergic diseases. Finally, microbiological studies show that H. pylori could be an indicator for changes in gut microbiome during recent decades, reflecting the complex interaction between microbes and immune system.
