Editorial
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Jun 26, 2015; 5(2): 55-61
Published online Jun 26, 2015. doi: 10.5662/wjm.v5.i2.55
Bartter and Gitelman syndromes: Spectrum of clinical manifestations caused by different mutations
Amar Al Shibli, Hassib Narchi
Amar Al Shibli, Department of Pediatrics, Tawam Hospital, Al Ain, United Arab Emirates
Hassib Narchi, Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
Author contributions: Both Al Shibli A and Narchi H have made substantial contributions to conception and design of the editorial, drafting the article or making critical revisions related to important intellectual content of the manuscript and final approval of the version of the article to be published.
Conflict-of-interest: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hassib Narchi, MD, FRCPCH, Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, PO Box 17666, United Arab Emirates. hassib.narchi@uaeu.ac.ae
Telephone: +971-3-7137414 Fax: +971-3-7672022
Received: December 17, 2014
Peer-review started: December 18, 2014
First decision: April 27, 2015
Revised: May 14, 2015
Accepted: June 4, 2015
Article in press: June 8, 2015
Published online: June 26, 2015
Processing time: 202 Days and 4.2 Hours
Core Tip

Core tip: As inherited disorders of renal tubular excretion and reabsorption of electrolytes, Bartter and Gitelman syndromes were previously considered as genotypic and phenotypic heterogeneous diseases. Although they share some characteristic features, the clinical and laboratory manifestations may not always allow distinction between them. Different genetic mutations inducing impairment of electrolytes transport across different sites of the nephron have been reported in each condition. However, considerable overlap exists between the different genotypes and phenotypes of these two conditions that are now better described as a spectrum of clinical manifestations caused by different gene mutations.