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World J Methodol. Mar 26, 2014; 4(1): 26-45
Published online Mar 26, 2014. doi: 10.5662/wjm.v4.i1.26
Published online Mar 26, 2014. doi: 10.5662/wjm.v4.i1.26
Molecular biomarkers for grass pollen immunotherapy
Florin-Dan Popescu, Department of Allergology, “Carol Davila” University of Medicine and Pharmacy, “Nicolae Malaxa” Clinical Hospital, Department of Allergology and Clinical Immunology, 022441 Bucharest, Romania
Author contributions: Popescu FD solely contributed to the manuscript.
Correspondence to: Florin-Dan Popescu, MD, PhD, Associate Professor, Department of Allergology, “Carol Davila” University of Medicine and Pharmacy, “Nicolae Malaxa” Clinical Hospital, Department of Allergology and Clinical Immunology, 022441 Bucharest, Sector 2, Romania. florindanpopescu@ymail.com
Telephone: + 40-21-2555405 Fax: + 40-21-2555275
Received: November 23, 2013
Revised: January 5, 2014
Accepted: February 16, 2014
Published online: March 26, 2014
Revised: January 5, 2014
Accepted: February 16, 2014
Published online: March 26, 2014
Core Tip
Core tip: A concomitant approach of the component-resolved diagnosis biomarkers used to guide prescription of grass pollen immunotherapy, particularly important in regions of the world where grass pollen seasons temporal overlap with other types of pollen, together with candidate predictive biomarkers of clinical efficacy for this type of immunotherapy, classified as tolerogenic dendritic cells and regulatory T cells biomarkers, antibodies biomarkers, especially functional ones, immune activation and immune tolerance soluble biomarkers and apoptosis biomarkers, represents a methodological original presentation with an important educational role in the field molecular allergy considered imperative for clinical practice.