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World J Methodol. Dec 26, 2013; 3(4): 65-69
Published online Dec 26, 2013. doi: 10.5662/wjm.v3.i4.65
Published online Dec 26, 2013. doi: 10.5662/wjm.v3.i4.65
Bone marrow cell-based regenerative therapy for liver cirrhosis
Takafumi Saito, Kyoko Tomita, Hiroaki Haga, Kazuo Okumoto, Yoshiyuki Ueno, Department of Gastroenterology, Yamagata University School of Medicine, Yamagata 990-9585, Japan
Author contributions: Saito T, Tomita K, Haga H, Okumoto K and Ueno Y contributed equally to this paper.
Correspondence to: Takafumi Saito, MD, Associate Professor, Department of Gastroenterology, Yamagata University School of Medicine, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan. tasaitoh@med.id.yamagata-u.ac.jp
Telephone: +81-23-6285309 Fax: +81-23-6285311
Received: September 25, 2013
Revised: November 6, 2013
Accepted: December 12, 2013
Published online: December 26, 2013
Revised: November 6, 2013
Accepted: December 12, 2013
Published online: December 26, 2013
Core Tip
Core tip: Bone marrow cells, which include multipotent progenitor cells, are capable of differentiation into liver cells. Autologous bone marrow infusion therapy has been applied to cirrhotic patients, and improvement of liver function parameters has been demonstrated. Although the efficacy of this treatment modality needs to be evaluated in more detail in a large number of patients, regenerative therapy using bone marrow cells for advanced liver diseases has considerable potential.