Cona MM, Witte P, Verbruggen A, Ni Y. An overview of translational (radio)pharmaceutical research related to certain oncological and non-oncological applications. World J Methodol 2013; 3(4): 45-64 [PMID: 25237623 DOI: 10.5662/wjm.v3.i4.45]
Corresponding Author of This Article
Yicheng Ni, MD, Professor of Medicine, PhD, Chief of Theragnostic Lab, Radiology Section, Department of Imaging and Pathology, University Hospitals, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium. yicheng.ni@med.kuleuven.be
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World J Methodol. Dec 26, 2013; 3(4): 45-64 Published online Dec 26, 2013. doi: 10.5662/wjm.v3.i4.45
An overview of translational (radio)pharmaceutical research related to certain oncological and non-oncological applications
Marlein Miranda Cona, Peter de Witte, Alfons Verbruggen, Yicheng Ni
Marlein Miranda Cona, Yicheng Ni, Department of Imaging and Pathology, Faculty of Medicine, Biomedical Sciences Group, KU Leuven, B-3000 Leuven, Belgium
Marlein Miranda Cona, Yicheng Ni, Molecular Small Animal Imaging Centre/MoSAIC, Faculty of Medicine, Biomedical Sciences Group, KU Leuven, B-3000 Leuven, Belgium
Peter de Witte, Alfons Verbruggen, Faculty of Pharmaceutical Sciences, Biomedical Sciences Group, KU Leuven, B-3000 Leuven, Belgium
Author contributions: Miranda Cona M and Ni Y contributed equally in writing the article and in reviewing the literature; Miranda Cona M, de Witte P, Verbruggen A and Ni Y participated in the revision for important intellectual content; Miranda Cona M, de Witte P, Verbruggen A and Ni Y approved the final version of submitted manuscript.
Supported by The KU Leuven Molecular Small Animal Imaging Center MoSAIC (KUL EF/05/08) and the center of excellence in vivo molecular imaging research; KU Leuven projects IOF-HB/08/009 and IOF-HB/12/018; the European Union (Asia-Link CfP 2006-EuropeAid/123738/C/ACT/Multi-Proposal No. 128-498/111); the National Natural Science Foundation of China, No. 81071828; and the Jiangsu Provincial Natural Science Foundation, No. BK2010594
Correspondence to: Yicheng Ni, MD, Professor of Medicine, PhD, Chief of Theragnostic Lab, Radiology Section, Department of Imaging and Pathology, University Hospitals, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium. yicheng.ni@med.kuleuven.be
Telephone: +32-16-330165 Fax: +32-16-343765
Received: September 4, 2013 Revised: October 3, 2013 Accepted: October 18, 2013 Published online: December 26, 2013
Core Tip
Core tip: Translational medicine converts scientific discovery into clinical applications. Radiopharmacy has played a multidisciplinary role. Based on unique necrosis avidity, OncoCiDia presents a generic approach for management of cancers, on which recent results on its optimization are summarized. Myocardial infarction is a clinical problem. A comparative study between infarct avid iodine-131 labeled-hypericin and commercial 99mTc-Sestamibi is presented. Cholelithiasis may cause biliary complications. The usefulness of Hyp as an optical imaging agent for cholelithiasis is demonstrated. Multiple uses of automatic contrast injectors may reduce costs but can cause cross-contaminations. We developed a radioactive method for safety evaluation of a new replaceable patient-delivery system.
