Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Dec 20, 2025; 15(4): 101459
Published online Dec 20, 2025. doi: 10.5662/wjm.v15.i4.101459
Need for combined therapy for a rare case of autoimmune autonomic ganglionopathy: A case report
Elena Angeloudi, Maria Xanthopoulou, Maria Lima, Athanasios C Kalyvas, Serafeim C Kotoulas, Maria Dimitriou, Panagiotis Ioannidis, Aris Liakos, Eleni Gigi
Elena Angeloudi, Maria Xanthopoulou, Aris Liakos, Eleni Gigi, Second Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki 54642, Greece
Maria Lima, Athanasios C Kalyvas, Maria Dimitriou, Panagiotis Ioannidis, Second Neurology Department, AHEPA University Hospital, Thessaloniki 54636, Greece
Serafeim C Kotoulas, Adult CF Unit, Pulmonary Department, General Hospital of Thessaloniki "G. Papanikolaou", Aristotle University of Thessaloniki, Thessaloniki 57010, Greece
Author contributions: Angeloudi E, Xanthopoulou M, Liakos A, and Gigi E conceptualized the study; Angeloudi E, Xanthopoulou M, Liakos A, and Gigi E developed the methodology; Ioannidis P, Lima M, and Gigi E validated the findings; Angeloudi E, Xanthopoulou M, Liakos A, Gigi E, Kalyvas AC, and Ioannidis P conducted the investigation; Kalyvas AC, Dimitriou M, and Kotoulas SC provided resources; Angeloudi E, Xanthopoulou M, Kalyvas AC, Lima M, Kotoulas SC, and Dimitriou M curated the data; Angeloudi E prepared the original draft; Angeloudi E, Xanthopoulou M, Liakos A, Ioannidis P, and Gigi E reviewed and edited the manuscript; Liakos A, Ioannidis P, and Gigi E supervised the study.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Elena Angeloudi, MD, MSc, Research Scientist, Second Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki 54642, Greece. elena-angeloudi@hotmail.com
Received: September 18, 2024
Revised: February 9, 2025
Accepted: February 24, 2025
Published online: December 20, 2025
Processing time: 323 Days and 16.8 Hours
Core Tip

Core Tip: This case highlights the potential benefit of combined immunoadsorption and rituximab therapy in refractory autoimmune autonomic ganglionopathy. Despite first-line therapy failure, the patient achieved significant long-term improvement, suggesting that a stepwise immunomodulatory approach may be necessary in resistant cases.