Observational Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Sep 20, 2025; 15(3): 100950
Published online Sep 20, 2025. doi: 10.5662/wjm.v15.i3.100950
Evaluation of macular and peripapillary structure and microvasculature with optical coherence tomography angiography in migraine in the Indian population
Pankti Shah, Virna M Shah, Veerappan Rathinasabapathy Saravanan, Karthik Kumar, Siddharth Narendran
Pankti Shah, Virna M Shah, Karthik Kumar, Department of Neuro Ophtalmology, Aravind Eye Hospital, Coimbatore 641014, Tamil Nādu, India
Veerappan Rathinasabapathy Saravanan, Department of Vitreoretina, Aravind Eye Hospital, Coimbatore 641014, Tamil Nādu, India
Siddharth Narendran, Division of Microbiology, Department of Cataract Services, Aravind Medical Research Foundation Regional Centre, Aravind Eye Hospital, Coimbatore 641014, Tamil Nādu, India
Author contributions: Shah P and Kumar K conducted the study; Shah P and Narendran S analyzed the data and wrote the paper; Shah VM supervised the study; Shah VM and Saravanan VR designed the study; All authors read and approved the final version of the manuscript to be published.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Aravind Eye Hospital, Madurai, India.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to use of anonymous patient data for research at the time of registration in the outpatient department. We applied the opt-out method to obtain consent for this study by using a poster. The poster was approved by the Institutional Review Board.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at virna@aravind.org.
STROBE statement: The authors have read the STROBE Statement-checklist of items-and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Virna M Shah, DO, Chief Physician, Department of Neuro Ophthalmology, Aravind Eye Hospital, Tamilnadu, Coimbatore 641014, Tamil Nādu, India. virna@aravind.org
Received: September 2, 2024
Revised: November 21, 2024
Accepted: December 9, 2024
Published online: September 20, 2025
Processing time: 186 Days and 21.9 Hours
Core Tip

Core Tip: Our observational study shows that there are microvascular and structural changes seen on optical coherence tomography angiography in migraine, and these changes could serve as a valuable non-invasive biomarker in its diagnosis.