Optimizing bone marrow harvesting sites for enhanced mesenchymal stem cell yield and efficacy in knee osteoarthritis treatment

doi:10.5662/wjm.v15.i2.101458

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Jun 20, 2025 (publication date) through Dec 4, 2024

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World Journal of Methodology

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2222-0682

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Methodol. Jun 20, 2025; 15(2): 101458
Published online Jun 20, 2025. doi: 10.5662/wjm.v15.i2.101458

Optimizing bone marrow harvesting sites for enhanced mesenchymal stem cell yield and efficacy in knee osteoarthritis treatment

Arulkumar Nallakumarasamy, Sandeep Shrivastava, Ravi Velamoor Rangarajan, Naveen Jeyaraman, Avinash Gandi Devadas, Swaminathan Ramasubramanian, Madhan Jeyaraman

Arulkumar Nallakumarasamy, Sandeep Shrivastava, Naveen Jeyaraman, Department of Orthopaedics, Datta Meghe Institute of Higher Education and Research, Wardha 442004, Maharashtra, India

Arulkumar Nallakumarasamy, Ravi Velamoor Rangarajan, Naveen Jeyaraman, Avinash Gandi Devadas, Madhan Jeyaraman, Department of Regenerative Medicine, Mother Cell Regenerative Centre, Tiruchirappalli 620017, Tamil Nadu, India

Swaminathan Ramasubramanian, Department of Orthopaedics, Government Medical College, Omandurar Government Estate, Chennai 600002, Tamil Nadu, India

Madhan Jeyaraman, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600077, Tamil Nadu, India

Author contributions: Nallakumarasamy A designed the research; Nallakumarasamy A and Jeyaraman N analyzed the articles for performing review; Nallakumarasamy A, Jeyaraman N, and Ramasubramanian S wrote the manuscript; Shrivastava S, Devadas AG, Rangarajan RV, and Jeyaraman M finalized the manuscript; all of the authors read and approved the final version of the manuscript to be published.

Conflict-of-interest statement: All authors declare no conflict of interest in publishing this manuscript.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Madhan Jeyaraman, MS, PhD, Assistant Professor, Research Associate, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Periyar EVR High Road (NH 4 Highway), Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com

Received: September 18, 2024
Revised: November 7, 2024
Accepted: November 20, 2024
Published online: June 20, 2025
Processing time: 73 Days and 16.2 Hours

Core Tip

Core Tip: Knee osteoarthritis (OA) has limited long-term treatments. Mesenchymal stem cells from bone marrow aspirate concentrate show promise for cartilage repair. However, variability in mesenchymal stem cell (MSC) yield from the sites necessitates further research to standardize techniques and optimize outcomes. Future directions include large-scale studies and personalized harvesting strategies to enhance MSC-based therapies for knee OA.