Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Sep 20, 2023; 13(4): 179-193
Published online Sep 20, 2023. doi: 10.5662/wjm.v13.i4.179
Compensated liver cirrhosis: Natural course and disease-modifying strategies
Ramesh Kumar, Sudhir Kumar, Sabbu Surya Prakash
Ramesh Kumar, Sudhir Kumar, Sabbu Surya Prakash, Department of Gastroenterology, All India Institute of Medical Sciences, Patna 801507, India
Author contributions: Kumar R designed the manuscript, collected data, and wrote the manuscript; Kumar S contributed to data collection and manuscript writing; Prakash SS contributed to data collection and assisted in the manuscript revision.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ramesh Kumar, MD, Additional Professor, Department of Gastroenterology, All India Institute of Medical Sciences, 4th floor, IPD Block-C, Patna 801507, India. docrameshkr@gmail.com
Received: April 22, 2023
Peer-review started: April 22, 2023
First decision: May 23, 2023
Revised: June 5, 2023
Accepted: June 27, 2023
Article in press: June 27, 2023
Published online: September 20, 2023
Processing time: 151 Days and 2.8 Hours
Core Tip

Core Tip: Compensated liver cirrhosis might be reversible if the underlying cause is treated before the disease progresses. The median survival for these individuals is typically 10-12 years; however, after the first decompensation, it drastically drops to 1-2 years. As a result, the outcomes of such patients can be significantly improved by integrating a number of disease-modifying therapy strategies that address complex pathophysiology, risk factors, and triggering events linked with disease progression. This article discussed the natural course of compensated liver cirrhosis, risk factors for its progression, and potential therapeutic strategies to favourably influence its natural evolution and enhance outcomes.