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World J Methodol. Nov 20, 2021; 11(6): 278-293
Published online Nov 20, 2021. doi: 10.5662/wjm.v11.i6.278
Preterm nutrition and neurodevelopmental outcomes
Alyson Margaret Skinner, Hassib Narchi
Alyson Margaret Skinner, Department of Paediatrics, Manor Hospital, Walsall Healthcare NHS Trust, Walsall WS2 9PS, West Midlands, United Kingdom
Alyson Margaret Skinner, Hassib Narchi, Department of Paediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain PO Box 17666, United Arab Emirates
Author contributions: Both authors contributed to the writing of the manuscript; Narchi H designed the figure.
Conflict-of-interest statement: No conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Alyson Margaret Skinner, BPharm, BSc, FRCP, MBChB, MD, MSc, Doctor, Department of Paediatrics, Manor Hospital, Walsall Healthcare NHS Trust, Moat Road, Walsall WS2 9PS, West Midlands, United Kingdom.
Received: March 28, 2021
Peer-review started: March 28, 2021
First decision: June 17, 2021
Revised: July 13, 2021
Accepted: September 27, 2021
Article in press: September 27, 2021
Published online: November 20, 2021
Core Tip

Core Tip: Survival of preterm infants has been steadily improving because of the many recent advances in perinatal and neonatal medicine. However, neither the growth of survivors reaches the ideal target level of the normal foetus of the same gestational age, nor is the optimum postnatal weight gain often achieved. In the preterm neonate, the brain is the most metabolically demanding organ. Growth is a marker of nutritional status and is also independently associated with long-term neurodevelopment. In this review, we will discuss the direct role of nutrition and the effect of general and specific nutritional interventions on neurodevelopment.