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World J Methodol. May 20, 2021; 11(3): 61-74
Published online May 20, 2021. doi: 10.5662/wjm.v11.i3.61
Concise review of stereotactic irradiation for pediatric glial neoplasms: Current concepts and future directions
Omer Sager, Ferrat Dincoglan, Selcuk Demiral, Bora Uysal, Hakan Gamsiz, Onurhan Colak, Fatih Ozcan, Esin Gundem, Yelda Elcim, Bahar Dirican, Murat Beyzadeoglu
Omer Sager, Ferrat Dincoglan, Selcuk Demiral, Bora Uysal, Hakan Gamsiz, Onurhan Colak, Fatih Ozcan, Esin Gundem, Yelda Elcim, Bahar Dirican, Murat Beyzadeoglu, Department of Radiation Oncology, Gulhane Medical Faculty, University of Health Sciences, Ankara 06018, Turkey
Author contributions: Sager O, Dincoglan F, Demiral S, Uysal B, Gamsiz H, Colak O and Ozcan F played significant role in data acquisition, interpretation of data, reviewing and writing of the manuscript; Gundem E, Elcim Y and Dirican B worked on checking the manuscript for important intellectual content; Beyzadeoglu M took part in designing, reviewing and writing of the manuscript and checking the manuscript for important intellectual content; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors state that they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Omer Sager, MD, Associate Professor, Department of Radiation Oncology, Gulhane Medical Faculty, University of Health Sciences, Gn.Tevfik Saglam Cad, Ankara 06018, Turkey. omersager@gmail.com
Received: November 17, 2020
Peer-review started: November 17, 2020
First decision: March 31, 2021
Revised: April 7, 2021
Accepted: April 14, 2021
Article in press: April 14, 2021
Published online: May 20, 2021
Processing time: 176 Days and 2.2 Hours
Core Tip

Core Tip: Pediatric gliomas comprise the majority of brain tumors in children. Radiotherapeutic management of pediatric gliomas poses a formidable challenge considering the adverse effects of irradiation for this vulnerable patient population. In this context, efforts have been focused on improving the toxicity profile of radiation delivery. Stereotactic irradiation with stereotactic radiosurgery or stereotactic radiotherapy in a single or few treatment fractions may serve as a viable radiotherapeutic approach to achieve this goal given the high conformality along with steep dose gradients around the target volume allowing for reduced normal tissue exposure under precise immobilization and image guidance.