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Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. May 20, 2021; 11(3): 46-60
Published online May 20, 2021. doi: 10.5662/wjm.v11.i3.46
Molecular diagnosis in cat allergy
Florin-Dan Popescu, Carmen Saviana Ganea, Carmen Panaitescu, Mariana Vieru
Florin-Dan Popescu, Carmen Saviana Ganea, Mariana Vieru, Department of Allergology and Clinical Immunology, “Nicolae Malaxa” Clinical Hospital, Bucharest 022441, Romania
Florin-Dan Popescu, Mariana Vieru, Department of Allergology, “Carol Davila” University of Medicine and Pharmacy, Bucharest 022441, Romania
Carmen Panaitescu, Department III Functional Sciences, Physiology Discipline, “Victor Babes” University of Medicine and Pharmacy, Timișoara 300041, Romania
Carmen Panaitescu, Center for Gene and Cell Therapies in Cancer Treatment OncoGen-SCJUPB Timisoara, Timișoara 300041, Romania
Author contributions: Popescu FD, Ganea CS, Panaitescu C and Vieru M contributed intellectually to this work and have read and approved the final version.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Florin-Dan Popescu, MD, PhD, Associate Professor, Chief Doctor, Department of Allergology, “Carol Davila” University of Medicine and Pharmacy, Sos Vergului 12, Sector 2, Bucharest 022441, Romania. florindanpopescu@ymail.com
Received: January 23, 2021
Peer-review started: January 23, 2021
First decision: February 14, 2021
Revised: February 22, 2021
Accepted: May 10, 2021
Article in press: May 10, 2021
Published online: May 20, 2021
Processing time: 109 Days and 10.3 Hours
Core Tip

Core Tip: Cats are a common source of allergens for humans, and allergy to these pets are frequent and variable in their clinical manifestations. The benefits of molecular diagnosis in cat allergy include use of the species-specific major allergen Fel d 1, cross-reacting allergen components, including those present in small quantities in natural extracts, while considering molecules that may impair the in vitro allergy diagnosis. The identification and characterization of molecular cat allergens with clinical significance has allowed their use in singleplex and multiplex immunoglobulin E immunoassays for a precision diagnostic approach.