Casu C, Inchingolo AM, Orrù G. Interleukin 10 supplement to reduce episodes of recurrent aphthous stomatitis. World J Methodol 2025; 15(3): 99176 [DOI: 10.5662/wjm.v15.i3.99176]
Corresponding Author of This Article
Cinzia Casu, PhD, Department of Surgical Science, Oral Biotechnology Laboratory, University of Cagliari, Via ospedale 54, Cagliari 09124, Italy. ginzia.85@hotmail.it
Research Domain of This Article
Dentistry, Oral Surgery & Medicine
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Cinzia Casu, Germano Orrù, Department of Surgical Science, Oral Biotechnology Laboratory, University of Cagliari, Cagliari 09124, Italy
Angelo Michele Inchingolo, Department of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, Bari 70124, Italy
Co-corresponding authors: Cinzia Casu and Germano Orrù.
Author contributions: Casu C and Orrù G observed the patients, collected data, made maps, and consulted the literature, they contributed equally to this article, they are the co-corresponding authors of this manuscript; Casu C and Inchingolo AM wrote the manuscript; Inchingolo AM and Orrù G revised the manuscript and the literature citations; and all authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Cinzia Casu, PhD, Department of Surgical Science, Oral Biotechnology Laboratory, University of Cagliari, Via ospedale 54, Cagliari 09124, Italy. ginzia.85@hotmail.it
Received: July 15, 2024 Revised: January 3, 2025 Accepted: February 8, 2025 Published online: September 20, 2025 Processing time: 233 Days and 9.8 Hours
Abstract
Recurrent aphthous stomatitis (RAS) is a very frequent condition in developed countries whose basic symptom is a lesion referred to as an aphthous ulcer. High levels of interleukin (IL)-1 and IL-6 and low salivary levels of IL-10 are the basis of RAS pathogenesis. Sublingual supplements based on IL-10 can be very useful in reducing the phenomenon of aphthous recurrence in patients with RAS. An observational clinical experience with a group of 5 patients with RAS receiving a commercially available IL-10-based supplement was reported by the authors. The findings revealed a subsequent reduction in the incidence of mouth ulcers.
Core Tip: Aphthous lesions and recurrent aphthous stomatitis are among the most common oral diseases and are often very painful. In some patients, the frequency of new onset is greater than once a month. The pathogenetic mechanism involves high levels of interleukin (IL)-1 and IL-6 and low levels of IL-10. Although several aids that are able to reduce healing times and pain have been proposed in the scientific literature, there is still no treatment that drastically reduces the frequency of lesion onset. Supplements based on IL-10, administered at low doses for prolonged periods, referred to as low-dose medicine, could be effective in reducing relapses.
