Perivoliotis K, Baloyiannis I, Samara AA, Koutoukoglou P, Ntellas P, Dadouli K, Ioannou M, Tepetes K. Microvessel density in patients with gastrointestinal stromal tumors: A systematic review and meta-analysis. World J Methodol 2023; 13(3): 153-165 [PMID: 37456971 DOI: 10.5662/wjm.v13.i3.153]
Corresponding Author of This Article
Athina A Samara, MD, Surgeon, Department of Surgery, University Hospital of Larissa, Mezourlo Hill, Larissa 41110, Greece. at.samara93@gmail.com
Research Domain of This Article
Oncology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Methodol. Jun 20, 2023; 13(3): 153-165 Published online Jun 20, 2023. doi: 10.5662/wjm.v13.i3.153
Microvessel density in patients with gastrointestinal stromal tumors: A systematic review and meta-analysis
Konstantinos Perivoliotis, Ioannis Baloyiannis, Athina A Samara, Prodromos Koutoukoglou, Panagiotis Ntellas, Katerina Dadouli, Maria Ioannou, Konstantinos Tepetes
Konstantinos Perivoliotis, Ioannis Baloyiannis, Athina A Samara, Konstantinos Tepetes, Department of Surgery, University Hospital of Larissa, Larissa 41110, Greece
Prodromos Koutoukoglou, Katerina Dadouli, Research Methodology in Biomedicine, Biostatistics and Clinical Bioinformatics, University of Thessaly, 41110 41110, Greece
Panagiotis Ntellas, Maria Ioannou, Department of Pathology, University Hospital of Larissa, Larissa 41110, Greece
Author contributions: Perivoliotis K, Ntellas P, Baloyiannis I contributed to study conception and design; Dadouli K, Koutoukoglou P contributed to acquisition of data; Perivoliotis K, Ntellas P, Samara A contributed to analysis and interpretation of data; Perivoliotis K, Ntellas P contributed to drafting of manuscript; Ioannou M, Tepetes K contributed to critical revision.
Conflict-of-interest statement: The authors declare no potential conflicts of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Athina A Samara, MD, Surgeon, Department of Surgery, University Hospital of Larissa, Mezourlo Hill, Larissa 41110, Greece. at.samara93@gmail.com
Received: January 14, 2023 Peer-review started: January 14, 2023 First decision: April 13, 2023 Revised: April 30, 2023 Accepted: May 16, 2023 Article in press: May 16, 2023 Published online: June 20, 2023 Processing time: 157 Days and 2.9 Hours
Abstract
BACKGROUND
Gastrointestinal stromal tumors (GISTs) are considered the most common mesenchymal tumors of the gastrointestinal tract. Microvessel density (MVD) constitutes a direct method of vascularity quantification and has been associated with survival rates in multiple malignancies.
AIM
To appraise the effect of MVD on the survival of patients with GIST.
METHODS
This study adhered to Systematic reviews and Meta-Analyses guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. Electronic scholar databases and grey literature repositories were systematically screened. The Fixed Effects or Random Effects models were used according to the Cochran Q test.
RESULTS
In total, 6 eligible studies were identified. The pooled hazard ratio (HR) for disease free survival (DFS) was 8.52 (95%CI: 1.69-42.84, P = 0.009). The odds ratios of disease-free survival between high and low MVD groups at 12 and 60 mo did not reach statistical significance. Significant superiority of the low MVD group in terms of DFS was documented at 36 and 120 mo (OR: 8.46, P < 0.0001 and OR: 22.71, P = 0.0003, respectively) as well as at metastases rate (OR: 0.11, P = 0.0003).
CONCLUSION
MVD significantly correlates with the HR of DFS and overall survival rates at 36 and 120 mo. Further prospective studies of higher methodological quality are required.
Core Tip: This systematic review and meta-analysis summarize all available data regarding the prognostic role of microvessel density (MVD) in gastrointestinal stromal tumors (GISTs). MVD measurement affects long term GIST survival. However, further prospective studies are necessary.
