Adolescent idiopathic scoliosis (AIS) affects 2%-3% of adolescents, with conservative treatments like bracing and physiotherapeutic scoliosis-specific exercises (PSSEs) recommended for mild to moderate cases. However, patient compliance with these treatments is often low. Digital tools, including smartphone apps and web applications, offer capabilities such as spinal curvature monitoring, remote consultation, and reduction of health care professionals' workload. These tools may also enhance adherence by increasing motivation and providing real-time feedback, which can be particularly beneficial for patients struggling with brace discomfort or self-esteem concerns. Despite these potential benefits, research remains limited on how digital health technologies can specifically enhance conservative AIS treatment and improve patient outcomes.

This study aimed to explore the perspectives of multiple stakeholders, including patients, caregivers, and health care providers, on using digital health technologies to improve AIS treatment adherence and outcomes.

This qualitative research study was conducted in Norway and included 17 participants (1 medical doctor, 2 physiotherapists, 8 patients, 4 family caregivers, and 2 IT specialists). The study adhered to Norwegian regulations. After approval from authorities and approval of the study protocol, patients were recruited through the Norwegian Spine and Back Pain Organization. A portion of the sample was recruited through direct communication from one of the researchers. After obtaining written informed consent from all participants, 5 focus group interviews were conducted between April and June 2023. Data were transcribed, translated, and analyzed using a content analysis approach, with findings reviewed by 2 independent researchers for validation.

The content analysis revealed four key themes: (1) AIS-specific education and information, (2) psychosocial support for patients with AIS and community connection, (3) health care communication and access, and (4) treatment adherence to AIS and gamification. Participants highlighted the need for accessible, adolescent-friendly, and multilingual education on AIS; digital platforms for peer support; improved remote communication with health care providers; and gamification elements tailored to AIS challenges (eg, brace compliance tracking, avatar customization for self-expression, and real-time exercise feedback).

Key findings highlighted the need for accessible information, peer support, and better communication with health care providers, with gamification enhancing treatment adherence. The findings of this study show the potential of digital health technologies in AIS management through fostering accessible information, peer support, and improved communication with health care providers. Customized gamification features may further enhance adherence, offering actionable insights for clinical practice and future research.

Orthotic treatment is commonly used as a non-surgical intervention for managing moderate adolescent idiopathic scoliosis (AIS). Although prior studies have evaluated various factors influencing health-related quality of life (HRQoL) in the patients with AIS, the association between trunk appearance perception and HRQoL, including potential gender differences, remains insufficiently defined. This study investigated gender differences in trunk appearance perception and its relationship with QoL among the patients with moderate AIS undergoing orthotic treatment.

Patients with moderate AIS undergoing orthotic treatment were included, and HRQoL evaluations were conducted before treatment, as well as one and seven months after the initiation of orthotic treatment. The evaluation tools included the Trunk Appearance Perception Scale (TAPS), Scoliosis Research Society-22r (SRS-22r), and Brace Questionnaire (BrQ). The study time points were selected to capture baseline conditions, initial adaptation, and longer-term treatment effects.

A total of 34 females and 11 males participated in the study. No significant gender differences were observed in global HRQoL, with both groups consistently reporting low self-image and self-esteem. In females, increasing age was negatively correlated with TAPS scores, whereas in males, it showed a positive correlation. For females, higher compliance was associated with higher bodily pain scores on the BrQ (ρ = 0.417), indicating reduced pain levels. In contrast, among males, greater compliance was associated with poor trunk appearance perception after seven months (ρ = -0.619). While TAPS was unrelated to SRS-22r and BrQ in females, a more favorable trunk appearance in males was strongly related to better function and self-image scores on the SRS-22r after seven months (ρ = 0.614 and 0.703, respectively).

Trunk appearance perception and overall HRQoL were similar between females and males in this study. However, the score related to self-image was lower than other HRQoL domains.

Considering the radiation hazard of X-ray, safer, more convenient and cost-effective ultrasound methods are gradually becoming new diagnostic approaches for scoliosis. For ultrasound images of spine regions, it is challenging to accurately identify spine regions in images due to relatively small target areas and the presence of a lot of interfering information. Therefore, we developed a novel neural network that incorporates prior knowledge to precisely segment spine regions in ultrasound images.

We constructed a dataset of ultrasound images of spine regions for semantic segmentation. The dataset contains 3136 images of 30 patients with scoliosis. And we propose a network model (ICPPNet), which fully utilizes inter-class positional prior knowledge by combining an inter-class positional probability heatmap, to achieve accurate segmentation of target areas.

ICPPNet achieved an average Dice similarity coefficient of 70.83% and an average 95% Hausdorff distance of 11.28 mm on the dataset, demonstrating its excellent performance. The average error between the Cobb angle measured by our method and the Cobb angle measured by X-ray images is 1.41 degrees, and the coefficient of determination is 0.9879 with a strong correlation.

ICPPNet provides a new solution for the medical image segmentation task with positional prior knowledge between target classes. And ICPPNet strongly supports the subsequent reconstruction of spine models using ultrasound images.

While the etiology of adolescent idiopathic scoliosis remains unclear, it is assumed that paraspinal muscle imbalance contributes to curve progression. Previous studies have found the paraspinal muscles imbalance, but no study comprehensively analyzed the roles of different paraspinal muscle layers. Our study distinguished the thoracic paraspinal muscle into superficial, intermediate, and deep layers, and analyzed the imbalance of the 3 layers.

We retrospectively included adolescent idiopathic scoliosis patients with thoracic curve. The paraspinal muscle parameters including relative muscle cross-sectional area (rmCSA) and fatty infiltration in upper end vertebra, apical vertebra, and lower end vertebra regions and in superficial, intermediate, and deep layers were calculated. The parameters between convex and concave sides were compared by paired t-test. The correlation between paraspinal muscle parameters and radiographic parameters was tested by Spearman correlation analysis.

A total of 46 patients were included. In apical vertebra region, the rmCSA in superficial (P = 0.038), intermediate (P = 0.001), and deep (P = 0.001) layers on convex side was greater than that on concave side, while the fatty infiltration in intermediate (P = 0.023) and deep layers (P = 0.000) on concave side was greater than that on convex side. Radiographic parameters were associated with both intermediate ΔrmCSA (P = 0.002) and deep ΔrmCSA (P = 0.000).

Our research indicates that the severity of paraspinal muscle imbalance is different in three layers, with the deep layer most severe, followed by the intermediate layer, and the superficial layer least severe. The imbalance of deep muscle correlates strongly with radiographic parameters, suggesting its role as a compensatory adaptation to curve magnitude.

Adolescent Idiopathic Scoliosis (AIS) patients were previously demonstrated to walk with gait abnormalities preoperatively. Our objective was to compare preoperative to 2-year follow-up results using gait analysis in AIS patients undergoing posterior spinal fusion (PSF).

This is a retrospective single-center study. Patients with right thoracic curve, aged under 18 were included. They underwent low-dose biplanar radiographs preoperatively and at least 2 years after PSF. The day before surgery and at 2-year follow-up, quantitative gait analysis (QGA) was performed. Several gait parameters were recorded, such as sagittal and coronal thoracic and lumbar angles, dynamic CVA (dyn-CVA), dynamic SVA (dyn-SVA) and acromio-pelvis angle (APA). Motion of spine junctions were recorded (inflexion, flexion/extension and torsion).

49 patients were included (15.1 yo, 29.7 months FU). Main curve correction rate was 62.3 % ( ± 6.9). PSF led to a decrease in coronal thoracic and lumbar angles (13.2 vs -6° and -8.5 vs 0.9, p < 0.001, respectively). There was a significant decrease in Dyn-SVA (4.1 vs 3 cm, p < 0.001). Lumbo-sacral junction was significantly more in extension after spinal fusion (10.1 vs 14.4°, p < 0.001). APA changed from torsion toward the left to neutral position (-7.2 vs 0.0°, p < 0.001) with a significant decrease in range of motion (12.2 vs 9.6, p < 0.001). Increased lumbo-sacral extension was correlated to the number of levels fused (R=0.3740, p = 0.016). There was a positive correlation between LIV and the decrease of lumbo-sacral inflexion towards the right (R=-0.5036, p = 0.001).

Our study reveals that PSF led to several changes in gait pattern of AIS patients, including complete correction of torsional abnormalities, mainly influenced by Cobb angle correction. We found that more distal LIV led to a decrease of lumbo-sacral inflexion motion, but the consequences of such changes in the long run remain unclear, especially on the onset of disc degeneration.

Background/Objectives: Scoliosis screening aims to detect spinal deformities early and prevent progression. The Programa de Atención a la Salud de Niños y Adolescentes (PANA) in Spain includes primary care screenings at ages 5-6, 10-11, and 13-14, but its effectiveness remains unverified. First, we evaluated attendance rates in each phase. Second, a nine-year follow-up was used to determine outcomes in adolescents who completed all three phases of PANA. Methods: A retrospective-prospective cohort study was conducted. The retrospective phase analyzed records of 881 schoolchildren screened at a primary healthcare center in Lorca, Spain. The prospective phase re-evaluated 127 adolescents (94.1% of those who completed all three phases) after nine years using a standardized forward bending test (FBT) with scoliometer quantification. Results: Attendance declined from 73.2%, at age 5-6, to 20.5%, at age 13-14. Only 15.3% completed all three phases. At age 13-14, 11.1% had a positive FBT by visual assessment. Non-quantified FBT had low sensitivity (5.9%) but high specificity (96.7%). Nine years later, mean scoliometer-measured vertebral rotation was 3.6 ± 1.7° (thoracic) and 2.5 ± 1.4° (lumbar). Scoliosis suspicion (FBT > 5°) was 15.1%, but applying the FBT > 7° threshold it was reduced to 4%. Conclusions: The PANA program has limited effectiveness due to low attendance and lack of scoliometer use. Visual FBT without quantification increases false positives, reducing diagnostic accuracy. It is recommended that preventive assessments be conducted in schools by primary care physicians. Training in the use of the scoliometer is essential to improve scoliosis detection.

Adolescent idiopathic scoliosis (AIS) is a prevalent musculoskeletal condition affecting approximately 2-3% of the adolescent population. Although exercise-based therapeutic interventions are increasingly employed as non-surgical alternatives, their clinical and economic effectiveness remains underexplored in real-world settings. Recent advancements in active learning (AL) and machine learning (ML) techniques offer the potential to optimize treatment protocols by uncovering hidden predictors and enhancing model efficiency.

This retrospective study evaluated the clinical and cost-effectiveness of exercise-based therapy in 128 AIS patients treated between 2020 and 2023 at a tertiary public hospital. Patients were followed for 3 to 36 months. Clinical outcomes were assessed based on changes in Cobb angle, Visual Analogue Scale (VAS) scores for pain, and SRS-22r functional outcomes. Direct medical costs were extracted from institutional records to estimate the incremental cost-effectiveness ratio (ICER) and quality-adjusted life years (QALYs). In parallel, ML models, including Random Forest regression and AL strategies, were applied to predict treatment outcomes and enhance data labeling efficiency.

Exercise-based therapy resulted in a mean Cobb angle reduction of 6.8° (SD = 3.1), with significant improvements in pain and function (p < 0.001). The ICER was estimated at $1,730 per additional degree of Cobb angle correction, with a projected QALY gain of 0.03 per patient. While treatment duration was statistically non-significant in traditional regression analyses (p > 0.1), ML models identified it as a top predictor of both Cobb angle correction and pain reduction. The Random Forest model achieved an MAE of 0.84 and an RMSE of 1.06 for pain reduction predictions, while AL improved classification accuracy from 65 to 85% across five iterations by selectively labeling the most uncertain cases. Sensitivity analyses confirmed the robustness of economic findings.

Exercise-based therapy, combined with ML and AL techniques, appears to be a clinically effective and economically sustainable intervention for AIS management. ML models identified important predictors overlooked by classical methods, particularly highlighting the importance of treatment duration. These findings may inform evidence-based strategies for integrating personalized, data-driven approaches into conservative scoliosis treatment protocols and optimizing musculoskeletal healthcare resource allocation.

The use of rigid braces and specialized exercises for the treatment of adolescent idiopathic scoliosis (AIS), is the most common non-surgical approach used to prevent curvature progression. The study aims to assess the efficacy of a rigid brace (the Chêneau brace), in conjunction with SEAS (Scientific Exercise Approach to Scoliosis), as a conservative approach to the treatment of AIS.

The study involves a retrospective analysis of data collected prospectively from 119 patients with AIS who underwent treatment with the Chêneau brace and SEAS. Patients with AIS were eligible for treatment if they had a Cobb angle between 20° and 40° (at the time of initial treatment) and significant residual spine growth (Risser grade 0-2). It was recommended that patients wear the brace for a minimum of 22 h per day. The effectiveness of the treatment was assessed based on changes in the Cobb angle measurements. To evaluate the patients' perception of treatment outcomes, the Scoliosis Research Society-22 revised (SRS-22r) was administered before and after treatment. A multivariable logistic regression analysis was used to identify factors that may independently predict treatment success.

The use of the Chêneau brace, in combination with SEAS gymnastics, was effective for 99 patients (83.2%). Only six patients (5.1%) achieved a Cobb angle of the major curve greater than 45ο. There were no significant differences in treatment success based on the location of the curve. In the group of patients who followed the recommended wearing time for the brace and SEAS exercises, the rate of curvature progression was significantly lower than in the overall group (0% versus 16.8%, p = 0.004), and the group that partially or poorly followed the treatment protocol (0% versus 28%, p < 0.001).

The SRS-22r showed improvements in satisfaction with treatment from the start to the end of brace use, with an average score of 4.62 ± 0.54. The use of the Chêneau brace in combination with SEAS gymnastics has been shown to reduce the risk of spinal curvature progression in individuals with AIS.

To develop a temporal-convolutional-LSTM (TCN-LSTM) hybrid model integrating surface electromyography (sEMG) signals for forecasting post-Schroth Cobb angle progression in adolescent idiopathic scoliosis (AIS) patients, thereby offering accurate feedback for personalized treatment.

A total of 143 AIS patients were included. A systematic Schroth exercise training program was designed. sEMG data from specific muscles and Cobb angle measurements were collected. A neural network model integrating Temporal Convolutional Network (TCN), Long Short-Term Memory (LSTM) layers, and feature vectors was constructed. Four prediction models were compared: TCN-LSTM hybrid model, TCN, LSTM, and Support Vector Regression (SVR).

The TCN-LSTM hybrid model demonstrated superior performance, with Cobb angle-Thoracic (Cobb Angle-T) prediction accuracy reaching R2 = 0.63 (baseline) and 0.69 (Week 24), achieving overall R2 = 0.74. For Cobb angle-Lumbar (Cobb Angle-L), accuracy was R2 = 0.61 (baseline) and 0.65 (Week 24), with overall R2 = 0.73. The SVR model showed lowest performance (R2 < 0.12).

The TCN-LSTM hybrid model can precisely predict Cobb angle changes in AIS patients during Schroth exercises, especially in long-term predictions. It provides real-time feedback for clinical treatment and contributes to optimizing treatment plans, presenting a novel prediction approach and reference basis for evaluating the effectiveness of Schroth correction exercises in AIS patients.

This systematic review aimed to identify predictors of brace treatment outcomes for adolescents or adults with idiopathic scoliosis.

Four databases including MEDLINE, EMBASE, Web of Science, and CINAHL were searched. Free text and indexed terms identifying the populations, predictions analyses and key outcomes were combined to search the literature. Pairs from eight independent reviewers conducted abstracts and full-text screening, and data extraction. The Quality in Prognostic Studies (QUIPS) tool was used to assess the risk of bias (ROB). Strength of evidence summary statements were formulated based on the risk of bias and the consistency of the research findings.

The search found 2224 articles. After screening, seven articles were included. Only one article showed low ROB, while the others showed moderate ROB. All articles reported on patient-related outcome measurements (PROMS) of quality of life (QOL). Only one parameter achieved limited strength of evidence; shorter treatment time from one study predicted better long-term SRS-22 total scores. For other predictors, the level of evidence was unclear. Other predictors of long-term outcomes (> 1 year follow-up), from only 1 study on each outcome, were: larger Cobb angle predicted worse Spinal Appearance Questionnaire (SAQ) chest scores and worse depression; higher age predicted better SAQ curve scores, larger apical translations predicted worse SAQ shoulders and chest scores; a passive introverted personality or an active outgoing (MPI) character type predicted worse SRS-22 satisfaction; higher BMI predicted better SAQ curve, Rolland-Morris questionnaire (RMQ) lumbosacral pain, Quebec Back Pain Disability Scale (QDS) moving scores, and worse SRS-22 total; larger vital capacity predicted better QDS score; longer bracing (total) predicted worse depression; negative parental attitudes predicted worse depression; higher Strengths and Difficulties Questionnaire emotional symptoms, peer problems, prosocial behavior, and total scores predicted worse depression. Poor compliance from one short-term follow-up study predicted worse change of brace questionnaire (BRQ) for health perception, pain, physical and emotional functioning, and total scores. Moderate evidence from two studies with low and moderate RoB showed that age and Cobb angle did not predict long-term total SRS-22 score for prediction.

Eleven parameters predicted bracing outcomes, but most studies presented moderate risk of bias. Only one parameter, longer treatment time, with limited strength of evidence was predictive of better long-term SRS-22 total scores. Since most findings still present an unclear level of evidence, common weaknesses were identified to encourage design of high-quality studies predicting bracing outcomes.

Treating idiopathic Early Onset Scoliosis (idiopathic EOS) is challenging due to ongoing growth and extensive follow-ups. While bracing is effective for Adolescent Idiopathic Scoliosis (AIS), its value for children under 10 remains debated. This systematic review and meta-analysis evaluates the effectiveness of spinal bracing in idiopathic EOS, followed to skeletal maturity.

We searched Ovid Medline and Web of Science until November 1st, 2023. Studies included idiopathic EOS patients between the ages of 3 and 10 (corresponding to Juvenile Idiopathic Scoliosis), followed to skeletal maturity, with no more than 25% initiating bracing after age 11. The primary outcome was the percentage undergoing scoliosis surgery. Pooled outcomes were calculated using a random effects model and 95% confidence intervals.

Out of 417 studies, 15 met the inclusion criteria, encompassing 868 patients. All were observational with a high risk of bias. The pooled percentage of patients undergoing surgery was 40% (95% CI 27-55%). The percentage of patients with a 5-degree progression or more and those progressing beyond 45 degrees were 44% (95% CI 24-66%) and 33% (95% CI 17-54%), respectively. Factors including larger initial Cobb angles, younger age, smaller in-brace correction, and poor compliance were identified as progression risk factors.

Bracing may prevent progression to surgery in idiopathic EOS when initiated early, but progression and surgery are still more common compared to adolescents. This is the first systematic review and meta-analysis looking at the success of bracing in idiopathic EOS, followed up to skeletal maturity. The high bias and variability of included studies limit the strength of these conclusions, highlighting the need for high-quality research with innovative trial designs.

IV (systematic review of level IV studies).

Prior studies show that recovery pathway implementation after posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS) reduces length of stay (LOS) without increasing complications, but little is known about the sustainability and longitudinal outcomes of these initiatives. This study aimed to establish and continually improve a perioperative pathway for AIS patients undergoing PSF while tracking long-term LOS performance with iterative improvements.

Implementation of the AIS care pathway at a single freestanding tertiary children's hospital was initiated in January 2016 (Phase 1) with iterative annual changes and a comprehensive update in September 2021 (Phase 2). The pathway involves preoperative optimization, standardized protocols, multi-modal pain regimen, early transition to oral pain medications, and early and frequent mobilization. Outcomes were tracked longitudinally using quality-improvement methodology, and comparisons between each group were performed.

Four hundred thirty six AIS patients (86 pre-implementation, 257 Phase 1, 93 Phase 2) who underwent PSF were included. Baseline patient demographics and Cobb angles were similar. Hospital LOS decreased from 5.1 days pre-implementation to 2.3 days in a stepwise fashion corresponding with pathway modifications. Intensive care unit (ICU) admissions decreased from 100% pre-implementation to 0% during Phase 2. Perioperative order set compliance increased from 0% pre-implementation to 100%. There were no significant increases in readmissions or reoperations. Direct hospitalization costs decreased by $5854.95 per case.

A multidisciplinary perioperative pathway for AIS patients undergoing PSF significantly reduced hospital LOS by 55% and direct costs by 11.3%. Continuous improvement and data monitoring led to sustained positive outcomes over eight years.

III.

Background: Non-surgical management of adolescent idiopathic scoliosis (AIS) includes physiotherapeutic scoliosis-specific exercise (PSSE). Determining the efficacy of PSSE in AIS has been challenging as the clinical effect is closely linked to exercise compliance (a dose-response relationship), with home exercise programs (HEPs) showing a general trend for decreased participation over time. The existing literature reports contradictory definitions and parameters of appropriate PSSE compliance in AIS. As such, this scoping review is necessary for therapists to identify PSSE prescription consistency, enabling clear guidelines for improved PSSE compliance. Methods: A scoping review of the literature was conducted to synthesize original research from inception to November 2024 and reference lists were examined for studies reporting compliance, adherence, or motivational strategies for PSSE in AIS. Results: Fifteen articles with a focus on PSSE in AIS were included in this review. The results demonstrate that compliance (C) and adherence (A) are terms commonly used interchangeably, only half of the studies clearly define compliance and/or adherence, and some utilize motivational strategies; however, outcomes of compliance/adherence were often not reported in the Results section or reflected in the discussion of results. Conclusions: Compliance and/or adherence are inconsistently reported within studies and numerous variations exist in (1) the section of the paper it is mentioned, (2) whether the inclusion criteria hinged on patient compliance/adherence, and (3) whether motivational strategies were employed and outcomes reported. Notably, there was a lack of compliance or adherence reporting in Results and Discussion sections of papers. The definition of appropriate compliance and any effective motivational strategies to improve compliance to achieve the desired results for treatment of AIS remain undetermined.

Musculoskeletal abnormalities have been reported among female professional ballet performers due, in part, to intrinsic predispositions related to joint and/or connective tissue laxity and extrinsic effectors such as reduced energy availability, low body mass, and high training volumes that may increase the risk of developing idiopathic scoliosis (IS). The purpose of this investigation was to characterize IS prevalence in this population. We hypothesized that there would be elevated prevalence in female performers and that those with IS would exhibit reduced bone mineral density (BMD), body mass, fat mass, and lean mass.

A retrospective analysis of whole-body anteroposterior radiographs was performed on 98 professional ballet dancers (49 male performers [mean age, 25 ± 6 years] and 49 female performers [mean age, 27 ± 5 years]) from a single company. Body composition and BMD were assessed via dual x-ray absorptiometry. The criterion for IS was defined as a Cobb angle of >10°. The frequency of IS was plotted against general-population norms. A t test was used to compare demographic characteristics, anthropometrics, and BMD between performers with and without IS and to compare the Cobb angles between sexes. A Fisher exact test was used to compare the IS prevalence between sexes. The Type-I error was set at α = 0.05.

Compared with male performers, female performers had greater spinal asymmetry (mean Cobb angle, 7.98° [95% confidence interval (CI) width, 1.76°] for men and 4.02° [95% CI width, 1.00°] for women; p = 0.027). The prevalence of IS among male performers (3 [6.12%] of 49) was comparable with the general-population norms (0.31% to 5.60%). Women had an elevated prevalence of IS compared with men (10 [20.41%] of 49; p = 0.037) and with general-population norms (0.65% to 8.90%). Among women, performers with IS were observed to have a reduced percentage of body fat (p = 0.021) and reduced fat mass (p = 0.040) compared with performers without IS.

Female professional ballet performers demonstrate a heightened prevalence of IS that, in addition to intrinsic predisposition, is associated with modifiable factors such as reduced fat mass commonly associated with reduced energy availability known to impact musculoskeletal health in athletes. Future investigations should seek to determine the prevalence of IS in other young female athlete populations commonly exposed to high degrees of activity and reduced energy availability.

Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

Adolescent idiopathic scoliosis (AIS) is treated with various forms of conservative care or surgery, depending on the degree of severity. When AIS is detected early, it can be monitored and initially treated with reduced invasiveness to prevent further progression. AIS manifests itself through deformations of the trunk, which are mostly identified as asymmetries in manual clinical examination. Torsobarography is a new pressure-based surface topographic system for posture analysis and evaluates such associated morphologic asymmetries. The aim of this study is to investigate the diagnostic validity of torsobarography by examining correlation of extracted torsobarographic indices with the Cobb angle and its ability to differentiate between different severities of scoliosis: no scoliosis, mild scoliosis, and moderate scoliosis. A total of 87 subjects (51 females and 36 males) were examined with torsobarography. Six torsobarographic indices were calculated for all subjects: torsobarography angle (TBA), sagittal imbalance index (SII), torso asymmetry index (TAI), shoulder asymmetry angle (SAA), waist asymmetry angle (WAA), and pelvis asymmetry Angle (PAA). These indices were correlated with the Cobb angle, and the differences between severities were statistically analyzed. Three out of six indices (TBA, TAI, and WAA) were able to significantly distinguish between mild and moderate scoliosis. Additionally, those indices showed moderate correlation (ρ = 0.37-0.50) with the Cobb angle measurements. The WAA was the only statistically significant index capable of differentiating between no scoliosis and moderate scoliosis. This study is the first to demonstrate that torsobarography can distinguish between different severities of scoliosis and thus identify a scoliotic deformity that requires bracing over monitoring.

Study DesignOriginal research, cross-sectional study.ObjectivesEvaluate preferences of patients, caregivers, and patient-caregiver dyads for non-fusion vs fusion surgery.MethodsA survey-based discrete choice experiment included patients 12-15 years of age with idiopathic scoliosis and their caregivers. Preference weights were estimated for 2 types of attributes that differed between fusion and non-fusion surgery: treatment outcomes (ie, appearance, confidence in planned correction, spinal motion, device failure, reoperation, and recovery period) and procedure-type requirements associated with each surgery type. Correlations between preference weights for patients, caregivers, and dyads were calculated to assess preference concordance between cohorts.ResultsA total of 344 respondents (124 patients, 92 caregivers, and 128 patient/caregiver dyads) completed the survey. Appearance was the most important treatment outcome for the average respondent in all cohorts. For patients, the least important treatment outcome was recovery time, whereas reoperation rate was the least important treatment outcome for caregivers and dyads. After controlling for treatment outcomes, patients and patient-caregiver dyads preferred the procedure-type requirements associated with fusion surgery, while caregivers preferred the procedure-type requirements associated with non-fusion surgery. Preferences of respondents who completed the survey prior to surgery were similar to those who completed the survey after surgery. Patient and caregiver preferences were more similar to the preferences of dyads than to each other.ConclusionsPatients and patient-caregiver dyads preferred the procedure-type requirements associated with fusion surgery, while caregivers preferred the procedure-type requirements associated with non-fusion surgery. Appearance was the most important treatment outcome for patients, caregivers, and patient-caregiver dyads.

A prospective, comparative study on clinical, radiographic, and health-related quality of life (HRQoL) outcomes in adolescents with acute spondylolysis treated with a rigid thoracolumbar orthosis (Boston brace) or with a placebo (elastic lumbar support) with a 2-year follow-up time.

To compare outcomes of acute adolescent spondylolysis treated with a rigid thoracolumbar orthosis or a placebo with a 2-year follow-up time.

The benefits of the use of rigid orthosis for the treatment of spondylolysis and achieving a bony union of spondylolysis remain unclear.

Sixty consecutive patients with acute spondylolysis were prospectively enrolled. Three patients were excluded from the analysis as they did not fulfil the inclusion criteria. The first 14 patients were randomized, and the remaining 46 chose the treatment method themselves. Treatment time was 4 months, and the follow-up time was 2 years. HRQoL was measured using the Scoliosis Research Society-24 (SRS-24) outcome questionnaire. The primary outcome was the HRQoL at 24 months and whether treatment type, bony union of the spondylolysis, or development of spondylolisthesis affected it.

Thirty (30/57) patients were treated with a Boston brace, and 27 (27/57) patients with a placebo. The bony union rate of spondylolysis did not differ between study groups (20/30 vs. 17/27, respectively, P = 0.789). The HRQoL did not differ between treatment groups in the SRS-24 domains through follow-up ( P > 0.05 for all). Five patients (5/57) developed spondylolisthesis (mean slip: 4.2 mm) during the 2-year follow-up time. Nonunion of the spondylolysis predicted the development of spondylolisthesis ( P = 0.005), but the treatment type did not affect it ( P > 0.05). Two years after treatment, patients who had bony union had higher SRS-24 total ( P = 0.005) and satisfaction domain ( P < 0.001) compared with patients with nonunion.

A rigid brace is not necessary for the treatment of acute spondylolysis. Achieving a bony union of adolescent spondylolysis is desirable as their HRQoL is higher at 2 years.

Level II.

Study DesignRetrospective cohort study.ObjectivesPatients with trisomy 21 (T21) often have soft tissue differences that lead to greater risk of postoperative wound complications. Our aim was to use a matched cohort of adolescent idiopathic scoliosis (AIS) patients with >2 year outcomes to determine odds of specific wound complications when comparing T21 and AIS patients.Methods14 T21 and 544 AIS patients were available for matching. Propensity score matching was conducted using logistic regression models and yielded a 1:5 match of 14 T21 patients and 70 AIS patients. Bivariate analyses were conducted across both patient groups. The proportion of wound complications was estimated along with a 95% confidence interval. Multivariable logistic regression analysis was utilized to determine if there was a significant association between T21 patients and wound outcomes.Results64% of T21 patients experienced a wound complication (9/14; 95% CI = 35.63-86.02) while only 3% of the AIS patients experienced a wound complication (2/70; 95% CI = .50-10.86). Patients with T21 had 56.6 times the odds of having a wound complication compared to matched AIS patients (OR = 56.57; 95% CI = 8.12-394.35; P < .001), controlling for age at surgery, BMI percentile, and propensity score. T21 patients had 10.4 times the odds of reoperation compared to AIS patients (OR = 10.36; 95% CI = 1.62-66.02; P = .01).ConclusionT21 patients have 10.4× the odds of reoperation and 56.6× the odds of overall wound complication when compared to AIS patients in a 1:5 matched cohort with appropriate controls. This is important for surgical planning, surgeon awareness, and communication with families preoperatively.

The study of physiotherapeutic scoliosis-specific exercise (PSSE) for adolescent idiopathic scoliosis (AIS) is rapidly progressing. However, there are limited reports on the medium- to long-term effects of PSSE on scoliosis.

A systematic review and meta-analysis feasibility study were conducted according to the Cochrane and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. In our exhaustive search, we employed nine search formulas and four search databases according to a preregistered protocol. Identification, screening, eligibility, inclusion, and meta-analysis were performed through repeated meetings involving all coauthors. Each process was conducted by three or more authors.

A total of 1,518 studies were identified in the initial search. After manually reviewing abstracts and full texts, 11 studies were chosen for evaluation and reporting. The overall risk-of-bias was high in approximately half of the studies and moderate in the other half, with none found to have a low risk-of-bias. Only two randomized controlled trials (RCTs) specifically evaluated the therapeutic effect of PSSE on over a 1-year clinical course and the preventive ability of PSSE on surgery. One RCT reported that Cobb angle was substantially smaller in the PSSE group than in the control group at the final follow up, whereas the other found no significant difference between the groups. The methods of exercise intervention, control group selection, and timing of outcome assessments were not standardized in the selected studies. Thus, conducting a meta-analysis of the literature was deemed unfeasible at this time.

The certainty of the evidence that PSSE reduces the progression of Cobb angle in patients with AIS in the short and long term was extremely low. Accordingly, healthcare providers should carefully examine the current evidence when explaining and applying PSSE in such patients. High-quality studies addressing the long-term changes in Cobb angle and Cobb angle at bone maturity as primary outcomes are warranted.

Level 1.

Full-time wearing of an orthopedic brace has demonstrated effectiveness in limiting curve progression in adolescents with idiopathic scoliosis. However, treatment adherence is challenging, with an average wearing time of 13 h/day. Despite this issue, barriers to brace adherence have rarely been studied. The aim of this study was to develop and validate a new instrument tool to evaluate factors influencing brace adherence.

Our study followed the COnsensus-based Standards for the selection of health Measurement INnstruments criteria (COSMIN). A conceptual framework was initially defined, and experts elaborated, reviewed, and selected candidate items. We also investigated the MOBI's factorial structure and its psychometric properties.

The MOBI initial version included 32 items related to four conceptual barriers to adherence, namely social/emotional, treatment, patient, and health system/professional. The factorial analysis led to an 18-item inventory with an internal consistency of 0.85 with four better-defined barriers (treatment social/emotional support structure, patient's self-image and perception, treatment adverse effects, and treatment acceptability. The MOBI-18f correlates with the SRS-22 domain treatment satisfaction and pain and the SF-12 mental health. Patients with poor brace wear time and more severe scoliosis will score higher on the MOBI-18f questionnaire.

The MOBI-18f is a reliable and valid measure of patients' adherence to brace treatment. This questionnaire can be used to develop interprofessional adherence support intervention in AIS patients undergoing brace treatment.

Isolated thoracic fusion (ITF) for idiopathic scoliosis preserves lumbar segment motion but risks lumbar curve progression. This study examined if Lenke classification, residual disc wedging, or tilting at the lowest instrumented vertebrae (LIV) are associated with lumbar curve progression or adding-on after ITF.

A retrospective analysis of idiopathic scoliosis patients aged 8 to 12 years treated with primary ITF was conducted. Inclusion criteria were a diagnosis of idiopathic scoliosis, LIV T10-L1, and ≥2 years of postoperative follow-up. Growth, Lenke classification, lumbar magnitude, angle of disc wedging below the LIV, and LIV tilt were assessed preoperatively, at 6 weeks postoperative, and at final follow-up. Standard descriptive statistics and repeated measures ANOVA were performed, with significance set at P<0.05.

Fifty-seven patients were included, with a mean follow-up of 4.6 years (2 to 12 y). At surgery, 67% (38 patients) were Risser 0. There was no significant lumbar curve increase from the first (24 degrees±12) to the final follow-up (22 degrees±14, P=0.21). Patients with a lumbar curve ≥30 degrees at first follow-up (n=16) also showed no increase in curve magnitude (40 degrees±8 at first follow-up vs. 37 degrees±17 at final follow-up, P=0.47). Disc wedging ≥5 degrees and LIV tilt ≥5 degrees were not associated with lumbar curve progression (29 degrees±14 at first follow-up vs. 28 degrees±17 at final follow-up for disc wedging, P=0.52; and 30 degrees±12 at first follow-up vs. 27 degrees±16 at final follow-up for LIV tilt, P=0.28) or adding-on. Lenke classification was not associated with lumbar curve progression. However, Lenke 3 and 4 patients had larger curves immediately after surgery and final lumbar curves ≥45 degrees. Of 9 Lenke 3 and 4 patients, 3 had lumbar curves ≥45 degrees at the final follow-up. No Lenke 1 or 2 patients (0 out of 41) had lumbar curves ≥45 degrees at the final follow-up (P<0.01).

In pediatric ITF patients, disc wedging and LIV tilt were not associated with adding-on or lumbar curve progression.

Level III.

All-day braces are predominantly used for the conservative treatment of adolescent idiopathic scoliosis (AIS). The Charleston Bending Brace is a pure nighttime brace. The aim of this study was to investigate the primary in-brace correction of the main curve of AIS when treated with the Charleston Bending Brace. Specifically, the factors influencing major curve correction were examined.

The retrospective analysis included 97 patients with AIS who were treated between October 2010 and September 2020. Patients with secondary scoliosis or orthotic pretreatment were excluded. Standardized radiographs were used to determine the Cobb angle of the major and minor curves. Curve correction in relation to Lenke's classification, the Risser stage, and rotation were assessed at four different time points (t0: before treatment, t1: 6-12 months, t2: 13-24 months, and t3: 25-36 months during treatment).

The average Cobb of the main curve at the beginning of the study was 25.7°. The night brace achieved excellent in-brace correction at t1, with nearly half of the patients (43%) showing a correction exceeding 80%. Curve localization, the Lenke type, and the Nash-Moe rotation significantly influenced initial in-brace curve correction at t1. At t2, there was also a significant in-brace correction of the initial Cobb by 93.0%. Similar improvements were observed at t3 for in-brace correction as well as without the brace (p < 0.031).

The results of the study revealed good primary in-brace correction of the main curve of the AIS with the nighttime brace, which was at least equivalent when compared to values from the literature for the Chêneau brace. Also, while restricted to medium-term results due to our study limitations, the percentage of correction in out-of-brace data of our patients was similar to weaned 24 h brace patients.

Background/Objectives: This opinion paper provides a brief overview of the history of school scoliosis screening programs following the introduction. Methods: It outlines the international administrative policies of these programs, their impact on the frequency of surgical procedures, and the effects of discontinuing school-based scoliosis screenings. Results: The primary focus is on analyzing the role of "false positive" cases detected during the Adam's bending test, which has contributed to the discontinuation of these programs in certain countries. This focused discussion is based on the impact of growth on the relationship between spinal and rib cage deformities. Furthermore, we propose the selection of the optimal age range for screening, considering the correlation between idiopathic scoliosis prevalence and geographical latitude. Conclusions: Lastly, we emphasize the importance of continuing scoliosis screening programs in schools.

Hypophosphatasia (HPP) is a rare inherited metabolic disorder characterized by deficient activity of tissue-nonspecific alkaline phosphatase (TNAP) caused by variants in the ALPL gene. Disease manifestations encompass skeletal hypomineralization with rickets and lung hypoplasia, vitamin B6-dependent seizures, craniosynostosis, and premature loss of deciduous teeth. The clinical presentation can comprise failure to thrive with muscular hypotonia, delayed motor development, and gait disturbances later in childhood. In adults, pseudofractures are a characteristic indicator of severely compromised enzyme activity, but non-canonical symptoms like generalized musculoskeletal pain, weakness, and fatigue, frequently accompanied by neuropsychiatric and gastrointestinal issues are increasingly recognized as key findings in patients with HPP. The diagnosis is based on clinical manifestations in combination with persistently low alkaline phosphatase (ALP) activity, elevated levels of ALP substrates, specifically inorganic pyrophosphate (PPi), pyridoxal 5'-phosphate (PLP) or urine phosphoethanolamine (PEA), and genetic confirmation of a causative ALPL variant. Considering the wide range of manifestations, treatment must be multimodal and tailored to individual needs. The multidisciplinary team for comprehensive management of HPP patients should include expertise to ensure disease state metabolic and musculoskeletal treatment, dental care, neurological and neurosurgical surveillance, pain management, physical therapy, and psychological care. Asfotase alfa as first-in-class enzyme replacement therapy (ERT) for HPP has been shown to improve survival, rickets, and functional outcomes in severely affected children, but further research is needed to refine how enzyme replacement can also address emerging manifestations of the disease. Prospectively, further elucidating the pathophysiology behind the diverse clinical manifestations of HPP is instrumental for improving diagnostic concepts, establishing novel means for substituting enzyme activity, and developing integrative, multimodal care.

Background/Objectives: Bracing is an effective treatment for preventing curve progression in skeletally immature adolescent idiopathic scoliosis (AIS) patients. A novel hybrid brace has been developed to overcome the limitations of conventional rigid and soft braces. This study aimed to evaluate the clinical efficacy of the novel hybrid brace. Methods: We enrolled AIS patients who were candidates for brace treatment: aged 10-18 years, with a coronal Cobb angle of 20-45° and a Risser stage of 0-2. The primary outcome was the rate of successful brace treatment, defined as meeting all three criteria: (1) less than 5° of progression in the Cobb angle during follow-up, (2) less than 45° of Cobb angle at the final follow-up, and (3) avoidance of surgical treatment. Results: A total of 24 patients (1 male, 23 female) with a mean age of 12.2 ± 1.2 years were included in this study. At the initiation of bracing, the major curve had a mean Cobb angle of 34.5 ± 6.3° and an in-brace correction (IBC) rate of 41.5 ± 16.0%. The hybrid brace demonstrated a success rate of 91.7% (22/24) during a mean follow-up period of 22.1 ± 6.4 months. After brace treatment, seven (29.2%) patients showed an improvement of more than 5° in their Cobb angle. When compared to a matched control from a retrospective cohort, the hybrid brace demonstrated a greater success rate (91.7% vs. 83.3%) and a higher proportion of patients with an improved curve (29.2% vs. 12.5%), although statistically insignificant. Conclusions: A novel hybrid brace was effective in preventing curve progression in skeletally immature patients with AIS.

Previous reports have identified factors associated with open chest surgery for congenital heart disease (CHD) and scoliosis. However, these reports included conditions such as Down syndrome and Marfan syndrome, which involve both cardiac disease and scoliosis. The relationships between these factors and open chest surgery remain unclear. This study aimed to identify factors contributing to severe scoliosis in CHD patients who have undergone open chest surgery.

Seventy-four post-CHD surgery patients with severe scoliosis (Scoliosis group) and 30 post-CHD surgery patients without scoliosis (NS group), excluding those with any syndrome or intellectual disability, were retrospectively analyzed. Patient background characteristics and radiographic parameters were compared between the NS and Scoliosis groups. Furthermore, the patients in the Scoliosis group were classified into three categories, namely, mild scoliosis, moderate scoliosis, and severe scoliosis, and the results were compared among the four groups.

Eighteen patients in the NS group and 63 in the Scoliosis group met the inclusion criteria. Compared with the NS group, the Scoliosis group included significantly more girls and patients who had younger ages at first CHD surgery and multiple open chest surgeries. Severe scoliosis progression was observed in patients who underwent multiple surgeries for severe CHD with cardiomegaly.

Progression to severe scoliosis was noted in patients with younger ages at first CHD surgery and those who underwent multiple surgeries for severe CHD. Assessing spinal deformities should be a key aspect of postoperative care for CHD, particularly in patients with severe CHD who are undergoing multiple chest surgeries.

III.

Screening for adolescent idiopathic scoliosis (AIS) currently relies on clinical evaluations by trained practitioners, most commonly using a scoliometer. Modern structured light 3D scanning can generate high-quality 3D representations of surface anatomy using a mobile device. We hypothesized that a mobile-based 3D scanning system would provide accurate deformity assessments compared to a scoliometer.

Between August 2020 and June 2022, patients 10-18 years being evaluated for AIS in our clinic with a scoliosis radiograph obtained within 30 days of clinic evaluation and no history of spinal surgery were enrolled. Patients had 3D scans taken in the upright and forward bend positions, and the largest angle of trunk rotation (ATR) was measured by a scoliometer. Image processing software was used to analyze trunk shift (TS), coronal balance (CB), and clavicle angle (CL) in the upright position and the largest ATR in the forward bend position. 3D and scoliometer measurements were correlated to major curve magnitude. Multiple logistic regression models were created based on 3D and scoliometer measurements, controlling for demographic covariates.

Two hundred and fifty-eight patients were included in this study. Mean coronal major curve magnitude was 25.7° (range 0-100), and 59% had a thoracic major curve. There were good-to-excellent correlations between 3D and radiographic measures of TS, CB, and CL (r = 0.79, rs = 0.80, and r = 0.64, respectively, p < 0.001). Correlations between 3D and radiographic measures of largest lumbar and thoracic ATR also demonstrated good correlations (r = 0.64 for both, p < 0.001). Using Akaike's Information Criterion (AIC), a multivariable logistic regression model based on 3D scanning outperformed a scoliometer model.

Mobile device-based 3D scanning of TS, CB, and TS identifies clinically relevant scoliotic deformity and is more predictive of radiographic curve magnitude than scoliometer in this population. This new modality may facilitate scoliosis screening by decreasing the need for trained personnel or dedicated equipment and clinical space to perform screening tests.

II.

Adolescent idiopathic scoliosis (AIS) is the most prevalent pediatric spinal condition. During growth, moderate scoliosis is treated with a brace to minimize the risk of progression to the surgical range. However, a minority of patients meet brace indications, with a greater number presenting late, already appropriate for surgery. This study determines the treatment cost differential between brace candidates and late-presenting patients within a public health care setting.

This is a retrospective review of 373 consecutive AIS patients seen for initial consultation in 2014 and followed for 5 years, with a cost-analysis of the 166 patients that either met brace indications (n=63) or presented late (n=103). Patients meeting the Scoliosis Research Society's brace indications presented with a coronal curve magnitude between 25 and 40 degrees inclusive and were skeletally immature with a Risser ≤2. Late-presenting patients had coronal curve magnitudes of ≥50 degrees (n=73) or were presented with coronal curve magnitudes of >40 degrees and were skeletally immature with Risser ≤2 (n=30). Total treatment cost was estimated for 3 scenarios: (1) use of predetermined cut points for treatment prescription, (2) real-world approximation reflecting actual, nuanced clinical decision-making, and (3) the ideal situation, such that all late patients were instead seen as brace candidates.

Each patient who was prescribed a brace and avoided progression to the surgical range saved $23,000 in treatment costs. Eliminating late presentation of AIS would save at least $2 to $3 million per year at a single institution.

Significant cost savings can be found by optimizing the number of patients treated with a brace and minimizing the number of patients that present late as likely surgical candidates. This study provides financial impetus for early AIS detection, decreasing the number of avoidable surgeries. Scoliosis screening recommendations in primary care should be re-examined, alongside the development of educational tools, equipping primary care providers, and youth and their caregivers with appropriate knowledge on how to identify AIS.

Level III-retrospective comparative study.

Bracing is a widely used conservative treatment for adolescent idiopathic scoliosis (AIS) patients, yet there is no consensus on the optimal amount of force applied. Although a number of different sensors have been developed to continuously monitor the applied pressure and force, they have several limitations, including inadequate overall force distribution and displacement. They also cause discomfort with limited wearability. In this study, body pressure mapping knitwear (BPMK) integrated with fourteen silicone-embedded fiber Bragg grating (FBG) sensors is developed to monitor immediate and overall changes in force during the bracing treatment. A wear trial of the BPMK is conducted by using a validated soft AIS mannequin, and prediction equations have been formulated for the FBG sensors at individual locations. The findings indicate that the measured forces are in good agreement with those obtained from clinical studies, with peak forces around the padding regions reaching approximately 2N. This was further validated by using finite element (FE) models. When comparing X-ray images, the estimated differences in Cobb angles were found to be 0.6° for the thoracic region and 2.1° for the lumbar region. This model is expected to provide valuable insights into optimal force application, thus minimizing the risk of injury and enhancing bracing compliance and efficacy. Ultimately, this innovative approach provides clinicians with data-driven insights for safer and more effective bracing applications, thus improving the quality of life of AIS patients.

Systematic Review and Meta-analysis.

This systematic review and meta-analysis aimed to: (1) synthesize the prevalent application ratios of 2 radiographic spinal flexibility assessment methods in AIS patients treated with PSF or bracing; and (2) quantitatively evaluate the accuracy of these methods in predicting post-intervention correction outcomes.

A systematic search was conducted across 5 electronic databases: CINAHL, Embase, Ovid, PubMed, and Web of Science. Meta-analyses were performed to investigate the accuracy of the spinal flexibility rate in predicting the post-intervention correction rate in AIS patients treated with PSF surgery or bracing, using RevMan 5.4.1 software.

The results of 31 studies, involving 1868 AIS patients, showed that the side-bending method was utilized more frequently than the fulcrum-bending method in both treatments. Meanwhile, the spinal flexibility evaluated by the fulcrum-bending method may provide a more accurate prediction of post-surgical correction compared to the side-bending approach, particularly for main curves. For the bracing treatment, only a few studies have preliminarily reported good capability of the side-bending method in predicting the initial in-brace correction.

This review quantitatively assessed the clinical application ratio and effectiveness of side-bending and fulcrum-bending radiographs in predicting post-intervention curve corrections in AIS patients undergoing surgical or bracing treatments. The results of the current review supported to adopt the fulcrum-bending approach for AIS patients undergoing PSF surgery with main thoracic curves, and the side-bending approach for those with thoracolumbar/lumbar curves. For patients receiving bracing treatment, further research is still needed to confirm the clinical value of the side-bending method.

Background: The purpose of this systematic review was to investigate the clinical outcome measures, either in separation or in conjunction with the Cobb angle, that were employed in randomized controlled trials to evaluate posture and spinal deformity. Methods: The PubMed, PEDro, OVID, and Scopus electronic databases were used to search for published articles from January 2004 to May 2024. All the searches included English language studies. Keywords were determined as "scoliosis, exercise, physical activity, brace, bracing, conservative treatment, rehabilitation, physiotherapy and physical therapy". Results: The most commonly used clinical evaluation parameters other than the Cobb angle in the studies were the ATR and surface topography measurements. The most commonly used assessment methods were POTSI asymmetry assessment performed with measurements made on photographs, the WRVAS, a deformity perception assessment evaluated with different photographs, and the SRS-22 scale, a disease-specific quality of life assessment. Conclusions: New developments in the treatment of scoliosis have brought about alternative measurement techniques that offer a more comprehensive view of patient outcomes. As a result of the review of the literature, it has emerged that radiation-free, valid, and reliable multidimensional evaluations should be performed in follow-up and treatment efficacy evaluations after initial diagnosis in adolescent idiopathic scoliosis.

The Bracing Adolescent Idiopathic Scoliosis (BASIS) study is a randomized controlled non-inferiority pragmatic trial of 'full-time bracing' (FTB) compared to 'night-time bracing' (NTB) for the treatment of adolescent idiopathic scoliosis (AIS). We anticipated that recruiting patients to BASIS would be challenging, as it is a paediatric trial comparing two markedly different bracing pathways. No previous studies have compared the experiences of AIS patients treated with FTB to those treated with NTB. This qualitative study was embedded in BASIS to explore families' perspectives of BASIS, to inform trial communication, and to identify strategies to support patients treated in a brace.

Semi-structured interviews were conducted with parents (n = 26) and young people (n = 21) who had been invited to participate in BASIS at ten of the 22 UK paediatric spine services in hospitals recruiting to BASIS. Audio-recorded interviews were transcribed and analyzed thematically.

Families viewed their interactions with BASIS recruiters positively, but were often confused about core aspects of BASIS, such as the aims, expectations of bracing, and the process of randomization. Participants typically expressed a preference for NTB, but recruiters may have framed NTB more favourably. Patients and parents reported challenges wearing a brace, such as physical discomfort, feelings of self-consciousness, difficulty participating in physical activities, and strain on financial resources to support brace use. Patients in FTB reported more pronounced challenges. While families valued health professional support, they felt there was a lack of social, emotional, and school support, and relied on online resources, as well private counselling services to address this need.

The findings informed the development of resources and strategies, including guidance for schools and the recommendations in this paper, to support patients to wear NTB and FTB as prescribed. The results indicated opportunities for recruiters to enhance trial communication in ways that could improve informed consent and recruitment to BASIS, and inform future trials of bracing.

Adolescent idiopathic scoliosis worsens mainly during growth at puberty. This is when non-operative treatment, by brace and physiotherapy, comes into its own. Only the brace has proven efficacy in stabilizing Cobb's angle. There are numerous types of brace and modalities of application, to be adapted to the scoliosis and the patient. What is crucial is that the patient should accept the brace, as compliance is one of the keys to success. The aim is, by the end of growth, to have a balanced spine with as little curvature as possible, to avoid aggravation and impaired quality of life in adulthood. LEVEL OF EVIDENCE: Expert opinion.

The biomechanical mechanism of brace intervention on bone, muscle, and disc should be comprehensively considered for AIS patients. We aimed to developmentally construct a musculoskeletal finite element model of adolescent idiopathic scoliosis to simulate the coupling of corrective forces and analyze the mechanical properties of bone, muscle, and disc. Investigateing, more effective clinical interventions to break the vicious cycle of patients during growth.

A finite element model, including muscle, bone, and disc, was established using computed tomography data of a patient with RigoA3 adolescent idiopathic scoliosis. The three-point force coupling, antigravity, and bending effects of the Chêneau brace were simulated, and the correction force of the secondary lumbar bend was gradually reduced while observing the mechanical characteristics of bone, muscle, and disc. The correction force in line with symmetrical spine growth was comprehensively evaluated.

The correction rate of the main thoracic (MT) curve, the intervertebral space height on the concave side of the vertebrae at the apex, and the stress ratio of the intervertebral discs were optimal when the maximum corrective pressure threshold was reached. However, the proximal thoracic (PT) curve was aggravated and the axial forces on the concave side were unbalanced. At this time, the biomechanical performance of the model is also not optimal. The correction rate of the Cobb Angle of the MT curve decreased with the decrease of the correction pressure in the lumbar region. When reduced to 25% of the maximum threshold, the convex side of disc stress, intervertebral space, and muscle axial force is more in line with the biomechanical mechanism of correction and can avoid sacrificing the PT curve.

Downward adjustment of the corrective force to the secondary lumbar curve, using the Chêneau brace, results in better primary thoracic curvature mechanics in the musculoskeletal finite element model, suggesting that breaking the vicious cycle of scoliosis progression to guide benign spinal growth is beneficial.

Adolescent idiopathic scoliosis (AIS) is a disabling spinal pathology, with a significant morbidity if left untreated. This review investigates the recent advances in the diagnosis and management of AIS.

Low radiation techniques have become a paramount focus in the management of patient's with AIS. The EOS system is growing in popularity due to lower radiation compared to conventional radiographs with the added advantage allowing 3D reconstruction. Bracing remains the standard treatment for curves amenable to this, however, due to the importance in compliance with brace wear there has been a recent push for more personalized brace construction using 3-dimensional printing. If curves are not amenable to bracing, then surgical intervention is generally recommended. Posterior spinal fusion (PSF) remains the gold standard; however, newer growth modulating techniques are in their infancy. Anterior vertebral body tethering (VBT) is a relatively novel method of treatment for AIS, that has seen promising early results. Due to its novelty and varying results VBT use remains limited and will need to be further investigated. AIS is a complex disease without a clear understanding of it's etiology. If identified earlier, then non-operative treatment may lead to prevention of curve progression and the need for surgical intervention. Newer technologies, such as the EOS system, allow 3D reconstruction of curves which can assist with pre-operative planning. PSF remains the gold standard surgical intervention for AIS, however, new developments in alternative techniques could have a promising future, especially for skeletally immature patients.

Adolescents with idiopathic scoliosis (IS) are often prescribed an orthosis to prevent curve progression and avoid surgery. Standard-of-care scoliosis orthoses are designed for full-time (FT) wear, which can be burdensome for some patients. Nighttime (NT) hypercorrective scoliosis orthoses are another option that has a lower impact on daily life, however, additional research is needed to guide the prescription of NT orthoses. The aim of this study was to assess the willingness of patients with IS and their parents/guardians to enroll in a randomized controlled study on bracing in scoliosis.

A cross-sectional study was conducted to survey adolescents with IS and their parents/guardians. Eligibility criteria for adolescent participants included: (1) diagnosis of IS, (2) no previous orthosis use, (3) currently seeing a provider for their scoliosis, and (4) able to communicate in English. Parent/guardian participants were the parent or guardian of an adolescent participant and were able to communicate in English. Separate online surveys were designed for adolescents and their parents/guardians. Surveys provided information about a hypothetical study and queried respondents about whether they would participate in the study, their willingness to randomize brace treatment, and their preferences for NT or FT bracing. Descriptive statistics were used to summarize survey data.

One hundred four adolescent/parent dyads completed the survey (104 adolescents and 103 parents). Most participants (adolescents: 55.8%, parents: 55.3%) indicated an interest in study participation, and approximately one-third of participants (adolescents: 31.8%, parents: 30.1%) reported that they would be willing to randomize to brace type. Most participants (adolescent: 77.0%, parent: 81.6%) preferred the NT brace if they needed brace treatment.

High-quality evidence is needed to inform the use of FT and NT scoliosis orthoses. Approximately a third of respondents would enroll in a randomized trial, indicating that multiple collaborative sites will be needed to recruit a sufficient sample into a randomized study on scoliosis bracing. Study findings also demonstrate support from adolescents and their parents/guardians for research on scoliosis bracing.

Menarche is widely recognized as one of the prognostic factors for curve progression in patients with adolescent idiopathic scoliosis (AIS). However, few studies focus on the relationship between small AIS curves without brace treatment and menarche, presenting a challenge to building further evidence.

This study aims to investigate the chronological changes in curve progression and risk of final brace initiation around menarche in small AIS curves under 25°.

This was a retrospective cohort study.

We longitudinally examined 1,090 AIS patients with a curve of less than 25° at the initial visit.

Patients were followed up until they achieved skeletal maturity or initiated brace treatment.

Curve progression based on time from menarche was analyzed using a t-test. Receiver operating characteristic curve analysis was performed based on the time from menarche, with curve magnitude as the independent variable and the final initiation of brace treatment as the dependent variable.

Overall, 1,090 female patients were included, with a mean initial visit age of 12.9 years (standard deviation [SD]: 1.5) and a mean coronal Cobb angle of 17.5° (SD: 4.3). Curve progression was significantly decreased between 0-1 and 1-2 years post-menarche (0-1 year post-menarche: 2.9°/year vs. 1-2 years post-menarche: 1.3°/year; p=.03). After 2 years from menarche, the mean curve progression was less than 0.4°/year. The cut-off value of the curve magnitude for the final initiation of brace treatment at the timing of menarche was 20.5° (area under the curve: 0.89, p<.001, 95% confidence interval: 0.86-0.91).

This study highlights that in small AIS curves under 25°, minimal curve progression was observed after 2 years post-menarche, aiding follow-up strategies for AIS conservative treatment.

Spinal orthoses are the most viable conservative treatment for scoliosis, and additive manufacturing techniques have shown huge perspective in producing patient-specific braces, reducing material waste, and production times. This pilot study aimed at determining whether 3D-printed braces could induce advantages or disadvantages compared to conventional braces in terms of mobility and gait, and at quantitatively evaluating the effects of braces on mobility and gait.

Ten participants were included in the study, eight with adolescent idiopathic scoliosis and two with osteogenesis imperfecta. Participants were asked to perform Timed-Up and Go (TUG) tests wearing a triaxial accelerometer under three conditions: unbraced, wearing a conventional (i.e., thermoformed) brace, and wearing a 3D-printed brace. After segmenting each TUG test in sub-phases, metrics quantifying gait and mobility were computed, and Friedman tests among all conditions were performed.

No significant differences in scoliotic patients mobility and gait between conventional and 3D-printed brace conditions were found, potentially suggesting that 3D-printed braces are as effective as conventional ones. Conversely, Stand flexion amplitude and Sit extension amplitude were lower in both conventional and 3D-printed brace conditions compared to the unbraced, meaning that braces limited the trunk range of motion. As for gait parameters, no significant differences in Walk Cadence and Walk Velocity among the three conditions were found, indicating that braces did not affect gait, at least during TUG tests.

The study was registered at Clinicaltrials.gov (Study ID NCT04282408, Date of Registration February 11th, 2020).

Orthosis-wearing compliance is crucial for achieving positive treatment outcomes in patients with adolescent idiopathic scoliosis (AIS), for whom 23 h of daily wear is typically prescribed. However, self-reported compliance is subjective and often based on patients' memory, leading to inaccuracies. While portable electronic devices have been developed to objectively monitor compliance, relying solely on temperature or force data can be insufficient. This study introduced a novel method that integrated both force and temperature data to estimate orthosis-wearing compliance. Twelve patients (eight females and four males) diagnosed with moderate AIS were included. Each patient was prescribed a thoracic-lumbar-sacral orthosis equipped with an integrated force and temperature sensor system. After one month of orthotic treatment, self-reported wear time averaged 17.8 ± 6.2 h/day, while the sensor indicated an average wear time of 13.3 ± 5.0 h/day. Most patients overestimated their compliance. Nighttime was the most common period for orthosis wear (6.1 h/day), whereas compliance during school hours (2.8 h/day) and after-school hours (3.7 h/day) was lower. The integration of force and temperature sensors provides a more comprehensive understanding of orthosis compliance. Future studies with larger samples and longer monitoring periods are needed to investigate the correlation between compliance and treatment outcomes.