Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar

For: Turkmen S, Cekic Gonenc O, Karaca Y, Mentese A, Demir S, Beyhun E, Sahin A, Gunduz A, Yulug E, Turedi S. The effect of ethyl pyruvate and N-acetylcysteine on ischemia-reperfusion injury in an experimental model of ischemic stroke. Am J Emerg Med 2016;34:1804-7. [PMID: 27324856 DOI: 10.1016/j.ajem.2016.06.003] [Citation(s) in RCA: 17] [Impact Index Per Article: 1.9] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/28/2016] [Revised: 05/31/2016] [Accepted: 06/02/2016] [Indexed: 12/21/2022] Open

For:	Turkmen S, Cekic Gonenc O, Karaca Y, Mentese A, Demir S, Beyhun E, Sahin A, Gunduz A, Yulug E, Turedi S. The effect of ethyl pyruvate and N-acetylcysteine on ischemia-reperfusion injury in an experimental model of ischemic stroke. Am J Emerg Med 2016;34:1804-7. [PMID: 27324856 DOI: 10.1016/j.ajem.2016.06.003] [Citation(s) in RCA: 17] [Impact Index Per Article: 1.9] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/28/2016] [Revised: 05/31/2016] [Accepted: 06/02/2016] [Indexed: 12/21/2022] Open

Number

Cited by Other Article(s)

Rossmann C, Darko A, Kager G, Ledinski G, Wonisch W, Wagner T, Hallström S, Reibnegger G, Paar M, Cvirn G. Natural Polyamine Spermidine Inhibits the In Vitro Oxidation of LDL. Molecules 2025;30:955. [PMID: 40005266 PMCID: PMC11858627 DOI: 10.3390/molecules30040955] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/21/2025] [Revised: 02/12/2025] [Accepted: 02/17/2025] [Indexed: 02/27/2025] Open

Affiliation(s)

Christine Rossmann Division of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria; (C.R.); (A.D.); (G.K.); (G.L.); (W.W.); (S.H.); (G.R.); (M.P.)
Azra Darko Division of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria; (C.R.); (A.D.); (G.K.); (G.L.); (W.W.); (S.H.); (G.R.); (M.P.)
Gerd Kager Division of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria; (C.R.); (A.D.); (G.K.); (G.L.); (W.W.); (S.H.); (G.R.); (M.P.)
Gerhard Ledinski Division of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria; (C.R.); (A.D.); (G.K.); (G.L.); (W.W.); (S.H.); (G.R.); (M.P.)
Willibald Wonisch Division of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria; (C.R.); (A.D.); (G.K.); (G.L.); (W.W.); (S.H.); (G.R.); (M.P.)
Thomas Wagner Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz, 8010 Graz, Austria;
Seth Hallström Division of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria; (C.R.); (A.D.); (G.K.); (G.L.); (W.W.); (S.H.); (G.R.); (M.P.) Division of Biomedical Research and Translational Medicine, Medical University of Vienna, 1090 Vienna, Austria
Gilbert Reibnegger Division of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria; (C.R.); (A.D.); (G.K.); (G.L.); (W.W.); (S.H.); (G.R.); (M.P.)
Margret Paar Division of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria; (C.R.); (A.D.); (G.K.); (G.L.); (W.W.); (S.H.); (G.R.); (M.P.)
Gerhard Cvirn Division of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria; (C.R.); (A.D.); (G.K.); (G.L.); (W.W.); (S.H.); (G.R.); (M.P.)

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Sharma V, Singh TG. Hypoxia-inducible Factor-1α Pathway in Cerebral Ischemia: From Molecular Mechanisms to Therapeutic Targets. CNS & NEUROLOGICAL DISORDERS DRUG TARGETS 2025;24:208-218. [PMID: 39428931 DOI: 10.2174/0118715273324551241008111827] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 05/31/2024] [Revised: 09/12/2024] [Accepted: 09/19/2024] [Indexed: 10/22/2024]

Tang L, Xie D, Wang S, Gao C, Pan S. Piezo1 Knockout Improves Post-Stroke Cognitive Dysfunction by Inhibiting the Interleukin-6 (IL-6)/Glutathione Peroxidase 4 (GPX4) Pathway. J Inflamm Res 2024;17:2257-2270. [PMID: 38633449 PMCID: PMC11022880 DOI: 10.2147/jir.s448903] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/08/2023] [Accepted: 03/19/2024] [Indexed: 04/19/2024] Open

Aziz N, Wal P, Sinha R, Shirode PR, Chakraborthy G, Sharma MC, Kumar P. A Comprehensive Review on the Significance of Cysteine in Various Metabolic Disorders; Particularly CVD, Diabetes, Renal Dysfunction, and Ischemic Stroke. Curr Protein Pept Sci 2024;25:682-707. [PMID: 38766817 DOI: 10.2174/0113892037287215240424090908] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/19/2023] [Revised: 03/20/2024] [Accepted: 03/27/2024] [Indexed: 05/22/2024]

Fayyazi F, Ebrahimi V, Mamaghani MM, Abgharmi BA, Zarrini G, Mosarrezaii A, Charkhian H, Gholinejad Z. N-Acetyl cysteine amide and cerium oxide nanoparticles as a drug delivery for ischemic stroke treatment: Inflammation and oxidative stress crosstalk. J Trace Elem Med Biol 2023;80:127300. [PMID: 37741051 DOI: 10.1016/j.jtemb.2023.127300] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/26/2023] [Revised: 09/04/2023] [Accepted: 09/05/2023] [Indexed: 09/25/2023]

Abstract

BACKGROUND

Inflammation and oxidative stress crosstalk is involved in the ischemic stroke(IS) pathogenesis and the new therapeutic options should be offered based on the targets that are critical in the golden hour of IS. YKL-40 and total antioxidant capacity(TAC), the inflammation and oxidative stress biomarkers, provide us with clues for proper intervention targets. N-acetyl cysteine amide (NACA), a lipophilic antioxidant, with a nanoparticle-based drug delivery system is permeable enough to penetrate blood-brain barrier (BBB) and was proposed as a new treatment option for IS. In this study, we evaluated the YKL-40 and TAC levels in the sera of IS patients to elucidate the best intervention target. A rat tissue model is used to assess the NACA efficiency. The microbiology tests performed to figure out the potential NACA and antibiotics interactions.

MATERIAL AND METHODS

The YKL-40 and TAC were measured in the serum of IS patients by ELISA and FRAP methods, respectively. The serum samples were obtained 12 h after the patient's admission and meantime other laboratory findings and NIHSS-based prognosis were recorded. In the animal study, the brain cortex, liver, kidney, adipose, and the heart of healthy rats were dissected and then incubated in DMEM cell culture media containing 50 micrograms/milliliter of nanoparticles; the nanoparticles were titanium dioxide nanoparticles (TiO2 NPs), copper oxide nanoparticles (CuO NPs) and cerium dioxide nanoparticles (CeO2 NPs). Olive oil and human serum albumin solution were exposed to the nanoparticles with and without NACA. TAC was measured in the supernatant culture media. With similar concentrations and settings, we evaluated the NACA, nanoparticle, and antibiotics interactions on pseudomonas aeruginosa.

RESULTS

There was a nonparametric correlation between YKL-40 levels and post stroke serum TAC levels. Nonsmokers had higher YKL-40 and TAC levels than smokers. A new calculated variable, urea*lymphocyte/age, predicts a poor prognosis with an acceptable AUC (0.708). Exposing to the nanoparticles, the liver, kidney, and brain had a significantly higher TAC than adipose and cardiac tissue. The NACA had an ameliorative effect against TiO2 NPs in the brain. This effectiveness of NACA was also observed against CuO NPs treatment. However, the CeO2 NPs exert a strong antioxidant property by reducing the TAC in the brain tissue but not the others. Albumin showed antioxidant properties by itself, but olive oil had an inert behavior. NACA had no interaction with the action of routine antibiotics.

CONCLUSION

Oxidative stress but not inflammation is the best point for intervention in IS patients because YKL-40 has not a relationship with NIHSS score. The CeO2 NPs and NACA combination are eligible option to develop antioxidant-based drug for the treatment of IS. As a complementary finding, the urea*lymphocyte/age is proposed as a NIHSS-based prognosis biomarker.

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Aydin H, Bulmus O, Korkut O, Altun E, Ulusal AE. An Evaluation of the Effectiveness of Melatonin and n-Acetylcysteine in Cerebral Ischemia-Reperfusion Injury in Adult Rats. MEDICINA (KAUNAS, LITHUANIA) 2023;59:2026. [PMID: 38004075 PMCID: PMC10672847 DOI: 10.3390/medicina59112026] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/04/2023] [Revised: 11/13/2023] [Accepted: 11/14/2023] [Indexed: 11/26/2023]

Rossmann C, Ranz C, Kager G, Ledinski G, Koestenberger M, Wonisch W, Wagner T, Schwaminger SP, Di Geronimo B, Hrzenjak A, Hallstöm S, Reibnegger G, Cvirn G, Paar M. Metformin Impedes Oxidation of LDL In Vitro. Pharmaceutics 2023;15:2111. [PMID: 37631325 PMCID: PMC10459002 DOI: 10.3390/pharmaceutics15082111] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/22/2023] [Revised: 07/13/2023] [Accepted: 07/26/2023] [Indexed: 08/27/2023] Open

Affiliation(s)

Christine Rossmann Division of Medicinal Chemistry, Otto Loewi Research Centre, Medical University of Graz, 8010 Graz, Austria; (C.R.); (C.R.); (G.K.); (G.L.); (W.W.); (S.P.S.); (B.D.G.); (S.H.); (G.R.); (M.P.)
Cornelia Ranz Division of Medicinal Chemistry, Otto Loewi Research Centre, Medical University of Graz, 8010 Graz, Austria; (C.R.); (C.R.); (G.K.); (G.L.); (W.W.); (S.P.S.); (B.D.G.); (S.H.); (G.R.); (M.P.)
Gerd Kager Division of Medicinal Chemistry, Otto Loewi Research Centre, Medical University of Graz, 8010 Graz, Austria; (C.R.); (C.R.); (G.K.); (G.L.); (W.W.); (S.P.S.); (B.D.G.); (S.H.); (G.R.); (M.P.)
Gerhard Ledinski Division of Medicinal Chemistry, Otto Loewi Research Centre, Medical University of Graz, 8010 Graz, Austria; (C.R.); (C.R.); (G.K.); (G.L.); (W.W.); (S.P.S.); (B.D.G.); (S.H.); (G.R.); (M.P.)
Martin Koestenberger Department of Pediatrics and Adolescent Medicine, Division of General Pediatrics, Medical University of Graz, 8010 Graz, Austria;
Willibald Wonisch Division of Medicinal Chemistry, Otto Loewi Research Centre, Medical University of Graz, 8010 Graz, Austria; (C.R.); (C.R.); (G.K.); (G.L.); (W.W.); (S.P.S.); (B.D.G.); (S.H.); (G.R.); (M.P.)
Thomas Wagner Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz, 8010 Graz, Austria;
Sebastian P. Schwaminger Division of Medicinal Chemistry, Otto Loewi Research Centre, Medical University of Graz, 8010 Graz, Austria; (C.R.); (C.R.); (G.K.); (G.L.); (W.W.); (S.P.S.); (B.D.G.); (S.H.); (G.R.); (M.P.) BioTechMed Graz, 8010 Graz, Austria
Bruno Di Geronimo Division of Medicinal Chemistry, Otto Loewi Research Centre, Medical University of Graz, 8010 Graz, Austria; (C.R.); (C.R.); (G.K.); (G.L.); (W.W.); (S.P.S.); (B.D.G.); (S.H.); (G.R.); (M.P.)
Andelko Hrzenjak Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, 8010 Graz, Austria;
Seth Hallstöm Division of Medicinal Chemistry, Otto Loewi Research Centre, Medical University of Graz, 8010 Graz, Austria; (C.R.); (C.R.); (G.K.); (G.L.); (W.W.); (S.P.S.); (B.D.G.); (S.H.); (G.R.); (M.P.) Division of Biomedical Research and Translational Medicine, Medical University of Vienna, 1090 Vienna, Austria
Gilbert Reibnegger Division of Medicinal Chemistry, Otto Loewi Research Centre, Medical University of Graz, 8010 Graz, Austria; (C.R.); (C.R.); (G.K.); (G.L.); (W.W.); (S.P.S.); (B.D.G.); (S.H.); (G.R.); (M.P.)
Gerhard Cvirn Division of Medicinal Chemistry, Otto Loewi Research Centre, Medical University of Graz, 8010 Graz, Austria; (C.R.); (C.R.); (G.K.); (G.L.); (W.W.); (S.P.S.); (B.D.G.); (S.H.); (G.R.); (M.P.)
Margret Paar Division of Medicinal Chemistry, Otto Loewi Research Centre, Medical University of Graz, 8010 Graz, Austria; (C.R.); (C.R.); (G.K.); (G.L.); (W.W.); (S.P.S.); (B.D.G.); (S.H.); (G.R.); (M.P.)

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McLaughlin RM, Top I, Laguna A, Hernandez C, Katz H, Livi LL, Kramer L, Zambuto SG, Hoffman-Kim D. Cortical Spheroid Model for Studying the Effects of Ischemic Brain Injury. IN VITRO MODELS 2023;2:25-41. [PMID: 39872876 PMCID: PMC11756444 DOI: 10.1007/s44164-023-00046-z] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 07/15/2022] [Revised: 02/23/2023] [Accepted: 02/27/2023] [Indexed: 01/30/2025]

Pan Z, Ma G, Kong L, Du G. Hypoxia-inducible factor-1: Regulatory mechanisms and drug development in stroke. Pharmacol Res 2021;170:105742. [PMID: 34182129 DOI: 10.1016/j.phrs.2021.105742] [Citation(s) in RCA: 54] [Impact Index Per Article: 13.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/05/2021] [Revised: 06/13/2021] [Accepted: 06/23/2021] [Indexed: 12/14/2022]

Mao L, Sun L, Sun J, Sun B, Gao Y, Shi H. Ethyl pyruvate improves white matter remodeling in rats after traumatic brain injury. CNS Neurosci Ther 2020;27:113-122. [PMID: 33369165 PMCID: PMC7804862 DOI: 10.1111/cns.13534] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/31/2020] [Revised: 10/21/2020] [Accepted: 10/31/2020] [Indexed: 12/12/2022] Open

The effect of three polyphenols and some other antioxidant substances on amyloid fibril formation by Human cystatin C. Neurochem Int 2020;140:104806. [DOI: 10.1016/j.neuint.2020.104806] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/28/2020] [Revised: 05/26/2020] [Accepted: 07/07/2020] [Indexed: 01/24/2023]

Oppedisano F, Maiuolo J, Gliozzi M, Musolino V, Carresi C, Nucera S, Scicchitano M, Scarano F, Bosco F, Macrì R, Ruga S, Zito MC, Palma E, Muscoli C, Mollace V. The Potential for Natural Antioxidant Supplementation in the Early Stages of Neurodegenerative Disorders. Int J Mol Sci 2020;21:ijms21072618. [PMID: 32283806 PMCID: PMC7177481 DOI: 10.3390/ijms21072618] [Citation(s) in RCA: 34] [Impact Index Per Article: 6.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/02/2020] [Revised: 04/07/2020] [Accepted: 04/07/2020] [Indexed: 02/06/2023] Open

Affiliation(s)

Francesca Oppedisano IRC-FSH Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy; (F.O.); (J.M.); (M.G.); (V.M.); (C.C.); (S.N.); (M.S.); (F.S.); (F.B.); (R.M.); (S.R.); (M.C.Z.); (E.P.); (C.M.) Nutramed S.c.a.r.l, Complesso Ninì Barbieri, Roccelletta di Borgia, 88021 Catanzaro, Italy
Jessica Maiuolo IRC-FSH Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy; (F.O.); (J.M.); (M.G.); (V.M.); (C.C.); (S.N.); (M.S.); (F.S.); (F.B.); (R.M.); (S.R.); (M.C.Z.); (E.P.); (C.M.) Nutramed S.c.a.r.l, Complesso Ninì Barbieri, Roccelletta di Borgia, 88021 Catanzaro, Italy
Micaela Gliozzi IRC-FSH Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy; (F.O.); (J.M.); (M.G.); (V.M.); (C.C.); (S.N.); (M.S.); (F.S.); (F.B.); (R.M.); (S.R.); (M.C.Z.); (E.P.); (C.M.) Nutramed S.c.a.r.l, Complesso Ninì Barbieri, Roccelletta di Borgia, 88021 Catanzaro, Italy
Vincenzo Musolino IRC-FSH Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy; (F.O.); (J.M.); (M.G.); (V.M.); (C.C.); (S.N.); (M.S.); (F.S.); (F.B.); (R.M.); (S.R.); (M.C.Z.); (E.P.); (C.M.) Nutramed S.c.a.r.l, Complesso Ninì Barbieri, Roccelletta di Borgia, 88021 Catanzaro, Italy
Cristina Carresi IRC-FSH Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy; (F.O.); (J.M.); (M.G.); (V.M.); (C.C.); (S.N.); (M.S.); (F.S.); (F.B.); (R.M.); (S.R.); (M.C.Z.); (E.P.); (C.M.) Nutramed S.c.a.r.l, Complesso Ninì Barbieri, Roccelletta di Borgia, 88021 Catanzaro, Italy
Saverio Nucera IRC-FSH Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy; (F.O.); (J.M.); (M.G.); (V.M.); (C.C.); (S.N.); (M.S.); (F.S.); (F.B.); (R.M.); (S.R.); (M.C.Z.); (E.P.); (C.M.)
Miriam Scicchitano IRC-FSH Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy; (F.O.); (J.M.); (M.G.); (V.M.); (C.C.); (S.N.); (M.S.); (F.S.); (F.B.); (R.M.); (S.R.); (M.C.Z.); (E.P.); (C.M.)
Federica Scarano IRC-FSH Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy; (F.O.); (J.M.); (M.G.); (V.M.); (C.C.); (S.N.); (M.S.); (F.S.); (F.B.); (R.M.); (S.R.); (M.C.Z.); (E.P.); (C.M.)
Francesca Bosco IRC-FSH Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy; (F.O.); (J.M.); (M.G.); (V.M.); (C.C.); (S.N.); (M.S.); (F.S.); (F.B.); (R.M.); (S.R.); (M.C.Z.); (E.P.); (C.M.) Nutramed S.c.a.r.l, Complesso Ninì Barbieri, Roccelletta di Borgia, 88021 Catanzaro, Italy
Roberta Macrì IRC-FSH Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy; (F.O.); (J.M.); (M.G.); (V.M.); (C.C.); (S.N.); (M.S.); (F.S.); (F.B.); (R.M.); (S.R.); (M.C.Z.); (E.P.); (C.M.) Nutramed S.c.a.r.l, Complesso Ninì Barbieri, Roccelletta di Borgia, 88021 Catanzaro, Italy
Stefano Ruga IRC-FSH Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy; (F.O.); (J.M.); (M.G.); (V.M.); (C.C.); (S.N.); (M.S.); (F.S.); (F.B.); (R.M.); (S.R.); (M.C.Z.); (E.P.); (C.M.)
Maria Caterina Zito IRC-FSH Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy; (F.O.); (J.M.); (M.G.); (V.M.); (C.C.); (S.N.); (M.S.); (F.S.); (F.B.); (R.M.); (S.R.); (M.C.Z.); (E.P.); (C.M.)
Ernesto Palma IRC-FSH Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy; (F.O.); (J.M.); (M.G.); (V.M.); (C.C.); (S.N.); (M.S.); (F.S.); (F.B.); (R.M.); (S.R.); (M.C.Z.); (E.P.); (C.M.) Nutramed S.c.a.r.l, Complesso Ninì Barbieri, Roccelletta di Borgia, 88021 Catanzaro, Italy
Carolina Muscoli IRC-FSH Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy; (F.O.); (J.M.); (M.G.); (V.M.); (C.C.); (S.N.); (M.S.); (F.S.); (F.B.); (R.M.); (S.R.); (M.C.Z.); (E.P.); (C.M.) Nutramed S.c.a.r.l, Complesso Ninì Barbieri, Roccelletta di Borgia, 88021 Catanzaro, Italy IRCCS San Raffaele, Via di Valcannuta 247, 00133 Rome, Italy
Vincenzo Mollace IRC-FSH Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy; (F.O.); (J.M.); (M.G.); (V.M.); (C.C.); (S.N.); (M.S.); (F.S.); (F.B.); (R.M.); (S.R.); (M.C.Z.); (E.P.); (C.M.) Nutramed S.c.a.r.l, Complesso Ninì Barbieri, Roccelletta di Borgia, 88021 Catanzaro, Italy IRCCS San Raffaele, Via di Valcannuta 247, 00133 Rome, Italy Correspondence: ; Tel.: +39-327-475-8007

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Kazaz IO, Mentese A, Demir S, Kerimoglu G, Colak F, Bodur A, Alver A, Kutlu O, Turedi S. Berberine inhibits the ischemia-reperfusion induced testicular injury through decreasing oxidative stress. Am J Emerg Med 2020;38:33-37. [DOI: 10.1016/j.ajem.2019.04.001] [Citation(s) in RCA: 13] [Impact Index Per Article: 2.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/28/2019] [Revised: 04/01/2019] [Accepted: 04/01/2019] [Indexed: 12/11/2022] Open

Demir S, Kazaz IO, Aliyazicioglu Y, Kerimoglu G, Teoman AS, Yaman SO, Arslan A, Mentese A. Effect of ethyl pyruvate on oxidative state and endoplasmic reticulum stress in a rat model of testicular torsion. Biotech Histochem 2019;95:317-322. [PMID: 31850805 DOI: 10.1080/10520295.2019.1695947] [Citation(s) in RCA: 14] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/22/2022] Open

Kazaz IO, Demir S, Yulug E, Colak F, Bodur A, Yaman SO, Karaguzel E, Mentese A. N-acetylcysteine protects testicular tissue against ischemia/reperfusion injury via inhibiting endoplasmic reticulum stress and apoptosis. J Pediatr Urol 2019;15:253.e1-253.e8. [PMID: 30890312 DOI: 10.1016/j.jpurol.2019.02.005] [Citation(s) in RCA: 16] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/30/2018] [Accepted: 02/05/2019] [Indexed: 12/21/2022]

Abstract

BACKGROUND

In animal models, endoplasmic reticulum (ER) stress has been reported to play a vital role in mediating ischemia/reperfusion (I/R) injury in certain organs, such as brain, liver, and intestine. However, there are a limited number of studies examining the relationship between ER stress and torsion and detorsion (T/D)-induced testicular injury.

OBJECTIVE

To investigate the effects of N-acetylcysteine (NAC) on ER-stress and apoptosis in an experimental testicular I/R injury model.

DESIGN

A non-blinded experimental study with three arms. Rats were divided into three groups: control group, T/D group, and NAC group. In the pretreatment of the NAC group, 20 mg/kg NAC was given intraperitoneally 30 min before detorsion. Tissue 4-hydroxynonenal (4-HNE), 78-kDa glucose-regulated protein (GRP78), and activating transcription factor 6 (ATF6) levels were determined using enzyme-linked immunosorbent assay. The apoptosis levels were evaluated using terminal deoxynucleotide transferase-mediated dUTP nick-end label assay.

RESULTS

In T/D group, tissue 4-HNE, GRP78, ATF6, and apoptotic index levels were significantly higher than control group. These increases were significantly reversed with NAC pretreatment.

DISCUSSION

There are some potential drugs that have been shown to reduce ER stress in the experimental ischemia model, and it is questioned that these drug candidates can be used as a therapeutic agent in the treatment of ischemic diseases in the near future. This study was not without limitations. First, the authors applied NAC only 20 mg/kg. In a future study, a dose-dependent assay should be performed to assess the likelihood of an additional testicular protective effect. One limitation of this research is also that in vivo studies cannot be extrapolated to possible effect in clinics. More experiments therefore need to be conducted to extrapolate the study findings to humans.

CONCLUSION

The study results showed that, after testicular torsion (TT), the ER stress-related apoptotic pathway plays a pivotal role in testicular injury. Further studies of other experimental models of TT may prove that NAC is a useful agent as an adjunctive treatment in surgical repair in human cases.

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