Regulatory roles of nitric oxide and angiotensin II on renal tubular transport

doi:10.5527/wjn.v3.i4.295

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World Journal of Nephrology

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2220-6124

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World J Nephrol. Nov 6, 2014; 3(4): 295-301
Published online Nov 6, 2014. doi: 10.5527/wjn.v3.i4.295

Table 1 Summary of angiotensin II effects on tubular transport

Nephron segment	Potential targets	Effects	Ref.
PT	NHE3, NBCe1	biphasic in rats, mice, rabbits	[19,27-32]
PT	J_HCO3	monophasic stimulation in humans	[84]
TAL	NKA, NKCC2, Cl channel	stimulation	[40-43]
TAL	NADPH oxidase	stimulation	[40-43]
DCT	NCC	stimulation	[47,49]
DCT	WNK4?	stimulation	[47,49]
CNT/CD	ENaC	stimulation	[55,59-61]

PT: Proximal tubule; TAL: Thick ascending limb; DCT: Distal convoluted tubules; CNT: Connecting tubules; CD: Collecting tubules; NHE3: Apical sodium-proton exchanger type 3; NBCe1: Basolateral electrogenic sodium-bicarbonate cotransporter type 1; NKA: Na⁺-K⁺-ATPase; NKCC2: Na⁺/K⁺/2Cl^- cotransporter; NCC: Sodium-chloride cotransporter; ENaC: Epithelial Na+ channel.

Table 2 Summary of nitric oxide effects on tubular transport

Nephron segment	Potential targets	Effects	Ref.
PT	NHE3, NBCe1	inhibition in rats, mice, rabbits	[65-68,84]
	J_HCO3	biphasic in rats?	[64]
		monophasic stimulation in humans	[84]
TAL	NKA, NKCC2	inhibition	[69-72]
TAL	J_Cl, J_HCO3	inhibition	[69-72]
CNT/CD	ENaC	inhibition	[81,83]

Citation: Horita S, Nakamura M, Shirai A, Yamazaki O, Satoh N, Suzuki M, Seki G. Regulatory roles of nitric oxide and angiotensin II on renal tubular transport. World J Nephrol 2014; 3(4): 295-301
URL: https://www.wjgnet.com/2220-6124/full/v3/i4/295.htm
DOI: https://dx.doi.org/10.5527/wjn.v3.i4.295