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World J Nephrol. Nov 6, 2014; 3(4): 295-301
Published online Nov 6, 2014. doi: 10.5527/wjn.v3.i4.295
Regulatory roles of nitric oxide and angiotensin II on renal tubular transport
Shoko Horita, Motonobu Nakamura, Ayumi Shirai, Osamu Yamazaki, Nobuhiko Satoh, Masashi Suzuki, George Seki
Shoko Horita, Motonobu Nakamura, Ayumi Shirai, Osamu Yamazaki, Nobuhiko Satoh, Masashi Suzuki, George Seki, Department of Internal Medicine, The University of Tokyo, Tokyo 113-0033, Japan
Author contributions: All authors contributed to this paper.
Correspondence to: George Seki, MD, Department of Internal Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. georgeseki-tky@umin.ac.jp
Telephone: +81-3-38155411 Fax: +81-3-58008806
Received: June 28, 2014
Revised: September 5, 2014
Accepted: October 1, 2014
Published online: November 6, 2014
Processing time: 132 Days and 3 Hours
Core Tip

Core tip: Angiotensin II (AngII) and nitric oxide (NO) play important roles in the regulation of renal tubular transport. AngII has a biphasic effect on renal proximal tubule (PTs) transport, and NO seems to inhibit the effect of AngII. In human PTs, however, AngII seems to have an NO-dependent monophasic stimulatory effect. We will discuss the recent findings in this field.