Retrospective Cohort Study
Copyright ©The Author(s) 2024.
World J Nephrol. Dec 25, 2024; 13(4): 99643
Published online Dec 25, 2024. doi: 10.5527/wjn.v13.i4.99643
Table 1 Main demographic, clinical and laboratory characteristics of adults with minimal change disease at presentation (mean ± SD)
Characteristics
Value
Age (years)26.34 ± 10.28 (18-60)
Gender [Male/Female, n (%)]15/8 (65.2/34.8)
Duration of symptoms (months)5.23 ± 8.64 (1-30)
Serum creatinine (mg/dL)1.03 ± 1.00 (0.50-5.50)
Serum albumin (g/dL)1.94 ± 0.90 (1.0-4.0)
Systolic blood pressure (mmHg)121.21 ± 16.76 (100-150)
Diastolic blood pressure (mmHg)79.47 ± 12.92 (58-110)
Urinary proteins (g/day)4.53 ± 2.43 (3-11)
Hematuria, n (%)2 (8.7)
Hypertension, n (%)7 (30.47)
AKI at presentation, n (%)1 (4.3)
Table 2 A comparison of baseline clinical and laboratory characteristics of adults with minimal change disease with international studies
Characteristics
Present study
Korbet et al[13]
Nolasco et al[14]
Mak et al[15]
Fujimoto et al[16]
Keskar et al[17]
Number of patients234089513361
Age (years) (mean ± SD)26.34 ± 10.2841 ± 2042 ± 1937 ± 1128 ± 1130.46 ± 13.43
Males (%)65.24856706754
Urinary proteins (g/day) (mean ± SD)4.53 ± 2.438.7 ± 5.710.216.412.45.33 ± 3.75
Serum Albumin (g/dL) (mean ± SD)1.94 ± 0.902.13 ± 0.81.91.71.82.0 ± 0.71
Hypertension (%)30.4721305596.55
Hematuria (%)8.72128331513.11
Table 3 Comparison of clinicopathologic characteristics of patients with and without relapse in adult minimal change disease (mean ± SD)
Characteristics
Patients with relapse (n = 4)
Patients without relapse (n = 17)
P value
Age (years)21.0 ± 2.9426.76 ± 10.650.30
Males, (%)10058.80.16
Systolic BP (mmHg)105.5 ± 9.71123.8 ± 15.40.03
Diastolic BP (mmHg)67.0 ± 6.081.76 ± 13.090.04
Serum Albumin (g/dL)1.25 ± 0.252.10 ± 0.960.05
Serum Cr (mg/dL)0.68 ± 0.120.86 ± 0.250.18
Urinary proteins (g/day)4.52 ± 2.814.21 ± 2.070.80
Duration of follow up (months)36.5 ± 19.638.47 ± 23.40.87
Serum Cr at last follow up (mg/dL)0.71 ± 0.550.83 ± 0.260.37
Remission at last follow up (%)7570.60.57
Normal renal function at last follow up (%)7576.50.69
Table 4 Final outcome in adults with minimal change disease
Characteristics
Present study
Korbet et al[13]
Nolasco et al[14]
Mak et al[15]
Fujimoto et al[16]
Keskar et al[17]
Follow up (months) (mean ± SD)38.09 ± 22.353.5 ± 47.191 ± 6338.9346.2 ± 2934.4
Remission (%)85.78077949487.5
Complete (%)71.47366909461.29
Partial (%)14.27114-26.22
Nephrotic at last follow-up (%)14.220623
ESRD (%)-512-1.6
Died (%)-81723-