Retrospective Cohort Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Dec 25, 2024; 13(4): 99643
Published online Dec 25, 2024. doi: 10.5527/wjn.v13.i4.99643
Adult minimal change disease: Clinicopathologic characteristics, treatment response and outcome at a single center in Pakistan
Shaheera Shakeel, Rahma Rashid, Nazarul H Jafry, Muhammed Mubarak
Shaheera Shakeel, Rahma Rashid, Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Transplantation, Karachi 74200, Sindh, Pakistan
Nazarul H Jafry, Department of Nephrology, Sindh Institute of Urology and Transplantation, Karachi 74200, Sindh, Pakistan
Author contributions: All four authors contributed significantly and equally to the preparation of the manuscript; Shakeel S and Mubarak M conceived and designed the study; Shakeel S, Rashid R, and Jafry NH performed the research; All four authors participated in primary and final drafting; Mubarak M critically reviewed and finalized the draft; All authors read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Sindh Institute of Urology and Transplantation.
Informed consent statement: All study participants provided informed written consent regarding personal and medical data collection before study enrolment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: Data are available from the first author and can be shared on reasonable request.
STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Muhammed Mubarak, FCPS, Professor, Department of Histopathology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drmubaraksiut@yahoo.com
Received: July 26, 2024
Revised: August 26, 2024
Accepted: September 19, 2024
Published online: December 25, 2024
Processing time: 103 Days and 17.1 Hours
Core Tip

Core Tip: Minimal change disease (MCD) constitutes the third most common cause of nephrotic syndrome in adults. The information is scanty on the clinicopathological features, treatment responses, and long-term outcomes of MCD in adults, particularly from developing countries. This study revealed that MCD in adults shows a favorable response to steroid therapy, with a majority achieving remission. However, relapses are common, necessitating second-line immunosuppressive treatments in some cases. The study highlights the need for standardized treatment guidelines for adult MCD to optimize outcomes.