Unique interstitial miRNA signature drives fibrosis in a murine model of autosomal dominant polycystic kidney disease

Figure 1 Laser capture microdissection of the peri-cystic local microenvironment. A: Trichrome-stained section of a dominant polycystic kidney diseased (ADPKD) kidney with representative laser capture microdissection (LCM) areas marked by red rectangles; B: Trichrome-stained section of an ADPKD kidney before and after LCM.

Figure 2 Heat map comparing miRNA expression. Heat map showing comparative expression of a set of miRNAs at three different post-natal (PN) time points (PN21, PN28 and PN42) for peri-cystic local microenvironmental regions and whole kidney samples (green represents downregulated miRNA expression, whereas red represents upregulated miRNA expression).

Figure 3 miRNA expression profiles. Expression profiles of a set of miRNAs at PN28 and PN42 that are temporally upregulated (A) and downregulated (B) when compared with PN21 in peri-cystic local microenvironmental regions.

Figure 4 miRNA expression profiles. Expression profiles of a set of miRNAs with significantly decreased (A) and increased (B) expression at PN42 in peri-cystic local microenvironmental regions compared with PN21.