Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
WNT/β-catenin signaling in urothelial carcinoma of bladder
Minal Garg, Niharika Maurya, Department of Biochemistry, University of Lucknow, Lucknow 226007, India
Author contributions: Garg M contributed to the conception and design of the study; Maurya N drafted the article; both the authors made critical revisions related to important intellectual content of the manuscript and approved the final version of the article to be published.
Conflict-of-interest statement: Authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Minal Garg, MSc, PhD, Doctor, Department of Biochemistry, University of Lucknow, University Road, Lucknow 226007, India. minal14@yahoo.com
Telephone: +91-522-2348968
Received: April 26, 2019
Peer-review started: May 9, 2019
First decision: August 2, 2019
Revised: August 14, 2019
Accepted: September 13, 2019
Article in press: September 16, 2019
Published online: September 26, 2019
Processing time: 154 Days and 21.2 Hours
Peer-review started: May 9, 2019
First decision: August 2, 2019
Revised: August 14, 2019
Accepted: September 13, 2019
Article in press: September 16, 2019
Published online: September 26, 2019
Processing time: 154 Days and 21.2 Hours
Core Tip
Core tip: Wnt/β-catenin signaling pathway plays significant role in maintaining balance between stemness and differentiation in adult stem cell niches. Mutations/epigenetic alterations in the regulatory components of Wnt/β-catenin signaling lead to acquisition of urothelial cancer stem cell phenotype, chemoresistance and enhanced survival. Key regulatory molecules of Wnt/β-catenin pathways are being examined as diagnostic/ prognostic markers as well as novel therapeutic targets in urothelial tumorigenesis.