Wiedermann CJ, Wiedermann W, Joannidis M. Causal relationship between hypoalbuminemia and acute kidney injury. World J Nephrol 2017; 6(4): 176-187 [PMID: 28729966 DOI: 10.5527/wjn.v6.i4.176]
Corresponding Author of This Article
Christian J Wiedermann, MD, Department of Research, College of Health Professions Claudiana, Lorenz-Böhler-Street 13, 39100 Bolzano, Italy. christian.wiedermann@claudiana.bz.it
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Nephrol. Jul 6, 2017; 6(4): 176-187 Published online Jul 6, 2017. doi: 10.5527/wjn.v6.i4.176
Causal relationship between hypoalbuminemia and acute kidney injury
Christian J Wiedermann, Wolfgang Wiedermann, Michael Joannidis
Christian J Wiedermann, Department of Research, College of Health Professions Claudiana, 39100 Bolzano, Italy
Wolfgang Wiedermann, Department of Educational, School and Counseling Psychology, University of Missouri College of Education, Columbia, MO 65211, United States
Michael Joannidis, Department of Internal Medicine, Division of Emergency and Intensive Care Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria
Author contributions: Wiedermann CJ and Joannidis M equally contributed to this paper with regard to conception, design and literature review; Wiedermann W and Joannidis M assessed data extraction and analysis performed by Wiedermann CJ who also drafted the manuscript; all authors are responsible for critical revision and editing, and approved the final version.
Conflict-of-interest statement: Christian J Wiedermann has received travel cost reimbursements from CSL Behring. Wolfgang Wiedermann has no conflict of interest to report. Michael Joannidis has received speaker’s honoraria from Astute Medical, Fresenius and Ortho Clinical Diagnostics.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Christian J Wiedermann, MD, Department of Research, College of Health Professions Claudiana, Lorenz-Böhler-Street 13, 39100 Bolzano, Italy. christian.wiedermann@claudiana.bz.it
Telephone: +39-04-71067300 Fax: +39-04-71067310
Received: February 14, 2017 Peer-review started: February 14, 2017 First decision: April 14, 2017 Revised: April 21, 2017 Accepted: May 3, 2017 Article in press: May 6, 2017 Published online: July 6, 2017 Processing time: 136 Days and 4 Hours
Core Tip
Core tip: The relationship between hypoalbuminemia and acute kidney injury (AKI)-related morbidity/mortality is now confirmed. This association is consistently evident in a wealth of observational studies conducted across a wide range of clinical settings, and suggests a causal link. Prospective studies adequately powered to assess severe AKI, mortality and causality are needed, as is evaluation of the trigger and appropriate target serum levels and albumin dose necessary to confer renal protection. Basic research is also warranted to define the mechanisms through which albumin affords nephroprotection. Serum albumin should be measured to identify patients with increased AKI risk who may benefit from treatment correcting underlying hypoalbuminemia.
