Oei E, Paudel K, Visser A, Finney H, Fan SL. Is overhydration in peritoneal dialysis patients associated with cardiac mortality that might be reversible? World J Nephrol 2016; 5(5): 448-454 [PMID: 27648408 DOI: 10.5527/wjn.v5.i5.448]
Corresponding Author of This Article
Dr. Stanley L Fan, Department of Renal Medicine and Transplantation, Barts Health NHS Trust, Whitechapel Road, Whitechapel, London E1 1BB, United Kingdom. s.fan@qmul.ac.uk
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Nephrol. Sep 6, 2016; 5(5): 448-454 Published online Sep 6, 2016. doi: 10.5527/wjn.v5.i5.448
Is overhydration in peritoneal dialysis patients associated with cardiac mortality that might be reversible?
Elizabeth Oei, Klara Paudel, Annemarie Visser, Hazel Finney, Stanley L Fan
Elizabeth Oei, Klara Paudel, Stanley L Fan, Department of Renal Medicine and Transplantation, Barts Health NHS Trust, London E1 1BB, United Kingdom
Annemarie Visser, Department of Nutrition and Dietetics, Barts Health NHS Trust, London E1 1BB, United Kingdom
Hazel Finney, Department of Clinical Biochemistry, Barts Health NHS Trust, London E1 1 BB, United Kingdom
Author contributions: Oei E and Fan SL designed the study, generated the tables and co-wrote the manuscript; Paudel K, Visser A and Finney H contributed to data collection and writing of the manuscript.
Institutional review board statement: The study (Is overhydration in peritoneal dialysis patients associated with cardiac mortality that might be reversible?) was conducted in accordance with the principles set out by the local ethical committee according to United Kingdom National Health Service audit and clinical service development.
Informed consent statement: The study (is overhydration in peritoneal dialysis patients associated with cardiac mortality that might be reversible?) was conducted in accordance with the principles set out by the local ethical committee according to United Kingdom National Health Service audit and clinical service development. Patient consent is not required for data to be included in an audit and clinical service development (Quality Assurance) assessment.
Conflict-of-interest statement: The authors have declared no conflict-of-interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Stanley L Fan, Department of Renal Medicine and Transplantation, Barts Health NHS Trust, Whitechapel Road, Whitechapel, London E1 1BB, United Kingdom. s.fan@qmul.ac.uk
Telephone: +44-20-35942674 Fax: +44-20-35942691
Received: March 17, 2016 Peer-review started: March 18, 2016 First decision: April 18, 2016 Revised: May 2, 2016 Accepted: July 11, 2016 Article in press: July 13, 2016 Published online: September 6, 2016 Processing time: 168 Days and 12.2 Hours
Core Tip
Core tip: Overhydration measured by bioimpedance spectroscopy is an independent predictor of death in peritoneal dialysis patients. Most studies on this topic provide only a single baseline bioimpedance assessment. We present longitudinal data showing increased cardiac mortality in overhydrated patients, and significant correlation of overhydration with cardiac troponin-T (cTnT) levels. Over 6 mo, these patients had a mean of 7.4 body composition monitor readings and 3.4 cTnT assessments. Patients whose hydration status improved showed a corresponding improvement in cTnT. While observational studies cannot define causality, our results show overhydration is associated with cardiac mortality, and suggest overhydration may be a reversible risk factor.
