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World J Nephrol. Mar 6, 2016; 5(2): 166-171
Published online Mar 6, 2016. doi: 10.5527/wjn.v5.i2.166
Published online Mar 6, 2016. doi: 10.5527/wjn.v5.i2.166
Cooling dialysate during in-center hemodialysis: Beneficial and deleterious effects
Stephanie M Toth-Manikowski, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, United States
Stephanie M Toth-Manikowski, Stephen M Sozio, Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States
Stephen M Sozio, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21287, United States
Author contributions: Toth-Manikowski SM contributed to conception of review topic and is primary contributor of the manuscript; Sozio SM contributed to conception of review topic and is editor of the manuscript.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Stephanie M Toth-Manikowski, MD, Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument St., Suite 416, Baltimore, MD 21287, United States. stephanie.toth-manikowski@bmc.org
Telephone: +1-410-9555268 Fax: +1-410-3672258
Received: September 11, 2015
Peer-review started: September 12, 2015
First decision: October 8, 2015
Revised: October 27, 2015
Accepted: December 17, 2015
Article in press: December 18, 2015
Published online: March 6, 2016
Peer-review started: September 12, 2015
First decision: October 8, 2015
Revised: October 27, 2015
Accepted: December 17, 2015
Article in press: December 18, 2015
Published online: March 6, 2016
Core Tip
Core tip: Cooled dialysate is commonly employed to reduce the incidence of intradialytic hypotension (IDH) in patients on chronic dialysis. The studies to date that have evaluated cooled dialysate are limited by small sample size and it has not become the standard of care for managing IDH. However, the small studies that exist are promising and suggest that cooling dialysate improves hemodynamic tolerability of dialysis, minimizes IDH, and exerts a protective effect over major organs including the heart and brain. More studies are needed to assess the long-term effects of cooling dialysate in this population.