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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. May 6, 2015; 4(2): 319-323
Published online May 6, 2015. doi: 10.5527/wjn.v4.i2.319
Published online May 6, 2015. doi: 10.5527/wjn.v4.i2.319
Prolonged hypernatremia triggered by hyperglycemic hyperosmolar state with coma: A case report
Darlene Vigil, Yijuan Sun, Antonios H Tzamaloukas, Karen S Servilla, Nephrology Section, Medicine Service, Raymond G Murphy Veterans Affairs Medical Center, Albuquerque, NM 87108, United States
Kavitha Ganta, Yijuan Sun, Richard I Dorin, Antonios H Tzamaloukas, Karen S Servilla, Nephrology Division, Department of Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States
Richard I Dorin, Endocrinology Section, Medicine Service, Raymond G Murphy Veterans Affairs Medical Center, Albuquerque, NM 87108, United States
Author contributions: Vigil D and Ganta K contributed equally to this work; Vigil D and Ganta K were responsible for parts of the bibliographic search and of the first draft of the report; Sun Y and Dorin RI made critical changes in the manuscript; Tzamaloukas AH assisted in the bibliographic search and wrote parts of the original report; Servilla KS conceived the work and made critical changes in the manuscript.
Ethics approval: NA.
Informed consent: Approval for this case report was obtained from the human research committee of the Raymond G Murphy VA Medical Center.
Conflict-of-interest: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Karen S Servilla, MD, Professor of Medicine, Nephrologist, Nephrology Section, Medicine Service, Raymond G Murphy Veterans Affairs Medical Center, 1501 San Pedro SE, Albuquerque, NM 87108, United States. karen.servilla@va.gov
Telephone: +1-505-2651711-4846 Fax: +1-505-2566442
Received: August 2, 2014
Peer-review started: August 2, 2014
First decision: October 14, 2014
Revised: January 7, 2015
Accepted: February 9, 2015
Article in press: February 11, 2015
Published online: May 6, 2015
Processing time: 279 Days and 10.3 Hours
Peer-review started: August 2, 2014
First decision: October 14, 2014
Revised: January 7, 2015
Accepted: February 9, 2015
Article in press: February 11, 2015
Published online: May 6, 2015
Processing time: 279 Days and 10.3 Hours
Core Tip
Core tip: Hyperglycemic coma with large losses of body water may aggravate lithium-induced nephrogenic diabetes insipidus (NDI) which had been asymptomatic and undiagnosed for years after cessation of lithium therapy. The development of conditions leading to loss of water and consciousness in patients who were on long term lithium therapy should trigger surveillance for NDI even when they were asymptomatic in the past.