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World J Nephrol. Nov 6, 2014; 3(4): 237-242
Published online Nov 6, 2014. doi: 10.5527/wjn.v3.i4.237
Role of insulin resistance in uric acid nephrolithiasis
Hanhan Li, Dane E Klett, Raymond Littleton, Jack S Elder, Jesse D Sammon
Hanhan Li, Dane E Klett, Raymond Littleton, Jack S Elder, Jesse D Sammon, VUI Center for Outcomes Research Analytics and Evaluation, Henry Ford Health System, Detroit, MI 48202, United States
Author contributions: Li H and Klett DE drafted and finalized the manuscript; Elder JS, Littleton R and Sammon JD critically revised the manuscript.
Correspondence to: Jesse D Sammon, DO, VUI Center for Outcomes Research Analytics and Evaluation, Henry Ford Health System, 2799 W. Grand Boulevard, Detroit, MI 48202, United States. jsammon79@gmail.com
Telephone: +1-207-6927167 Fax: +1-313-9164352
Received: June 25, 2014
Revised: July 21, 2014
Accepted: September 4, 2014
Published online: November 6, 2014
Processing time: 135 Days and 6.5 Hours
Core Tip

Core tip: Increasing awareness of the association between prevalence of metabolic syndrome and uric acid nephrolithiasis has caused a closer examination into modifiable risk factors for stone recurrence. The mechanism behind this association is thought to be due to decreased ammoniagenesis as caused by insulin resistance in the proximal tubule of the kidney. The presence or recurrence of uric acid stones should prompt the physician to look for traits of metabolic syndrome. Further studies into this causal relationship may provide additional medical interventions to decrease incident stones.