Kinin B2 receptor does not exert renoprotective effects on mice with glycerol-induced rhabdomyolysis

doi:10.5527/wjn.v3.i3.85

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Nephrol. Aug 6, 2014; 3(3): 85-91
Published online Aug 6, 2014. doi: 10.5527/wjn.v3.i3.85

Kinin B₂ receptor does not exert renoprotective effects on mice with glycerol-induced rhabdomyolysis

Pedro Paulo Gattai, Fernando Francisco Pazello Mafra, Frederick Wasinski, Sandro Soares Almeida, Marcos Antônio Cenedeze, Denise Maria Avancini Costa Malheiros, Reury Frank Pereira Bacurau, Carlos Castilho Barros, Niels Olsen Saraiva Câmara, Ronaldo Carvalho Araujo

Pedro Paulo Gattai, Fernando Francisco Pazello Mafra, Frederick Wasinski, Ronaldo Carvalho Araujo, Department of Biophysics, Laboratory of Genetics and Exercise Metabolism, Federal University of Sao Paulo - UNIFESP, Sao Paulo, CEP 04039-032, Brazil

Sandro Soares Almeida, Niels Olsen Saraiva Câmara, Federal University of Sao Paulo - UNIFESP, Sao Paulo, CEP 04039-032, Brazil

Marcos Antônio Cenedeze, Nephrology Division, Laboratory of Clinical and Experimental Immunology, Federal University of Sao Paulo – UNIFESP, Sao Paulo, CEP 04039-032, Brazil

Denise Maria Avancini Costa Malheiros, Renal Division, Department of Clinical Medicine, Laboratory of Renal Pathophysiology (LIM-16), Sao Paulo University - USP, Sao Paulo, CEP 04039-032, Brazil

Reury Frank Pereira Bacurau, School of Arts, Sciences and Humanities, Sao Paulo University - USP, Sao Paulo, CEP 04039-032, Brazil

Carlos Castilho Barros, Nutrition Faculty, Federal University of Pelotas, Rio Grande do Sul, CEP 96010-610, Brazil

Niels Olsen Saraiva Câmara, Department of Immunology, Laboratory of Transplantation in Immunobiology, Sao Paulo University - USP, Sao Paulo, CEP 05508-000, Brazil

Author contributions: Gattai PP, Mafra FFP, Wasinski F and Cenedeze MA performed the majority of experiments; Almeida SS, Malheiros DMAC and Barros CC provided vital reagents and analytical tools and were also involved in experiments; Gattai PP, Bacurau RFP, Camara NOS and Araujo RC were involved in editing manuscript, designed the study and wrote manuscript.

Supported by The National Council of Scientific and Technological Development - CNPq, No. 135020/2011-5

Correspondence to: Ronaldo Carvalho Araujo, PhD, Assistant Professor, Department of Biophysics, Laboratory of Genetics and Exercise Metabolism, Federal University of Sao Paulo - UNIFESP, Rua Pedro de Toledo, 669, 9º andar, Vila Clementino, Sao Paulo, CEP 04039-032, Brazil. araujo.ronaldo@unifesp.br

Telephone: +55-11-55764859

Received: December 4, 2013
Revised: April 24, 2014
Accepted: May 14, 2014
Published online: August 6, 2014
Processing time: 319 Days and 15.8 Hours

Core Tip

Core tip: In this work we are showing that glycerol-treated animals experienced impairment in renal function. Furthermore, we worked with kinin B₂ receptor knockout mice and our results suggest that kinin B₂ receptor does not exert renoprotective effects in this rhabdomyolysis model. In addition, we are presenting results of kidney expressions and we investigated several candidates that can participate in the kidney injury induced by glycerol.