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©2014 Baishideng Publishing Group Inc. All rights reserved.
Obesity in kidney disease: A heavyweight opponent
Raphael Jose Ferreira Felizardo, Department of Medicine, Nephrology Division, Federal University of São Paulo, São Paulo 04039-032, Brazil
Marina Burgos da Silva, Cristhiane Favero Aguiar, Niels Olsen Saraiva Câmara, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-900, Brazil
Author contributions: Felizardo RJF, Burgos-Silva M and Aguiar CF contributed equally to this work; Felizardo RJF, Burgos-Silva M and Aguiar CF performed research and wrote the paper; Câmara NOS analyzed the paper, discussed the topic and supervised the publication of this review.
Supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (São Paulo Research´s Foundation, FAPESP) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, INCT Complex Fluids and Renal Immunopathology Laboratory INSERM/CNPq), No. 12/15205-4, 12/02270-2, 12/16794-3, 12/23347-3
Correspondence to: Niels Olsen Saraiva Câmara, Professor, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof Lineu Prestes, 1730-Cidade Universitária, São Paulo 05508-900, Brazil. niels@icb.usp.br
Telephone: +55-11-30917388 Fax: +55-11-30917327
Received: March 18, 2014
Revised: April 18, 2014
Accepted: June 10, 2014
Published online: August 6, 2014
Processing time: 215 Days and 18 Hours
Revised: April 18, 2014
Accepted: June 10, 2014
Published online: August 6, 2014
Processing time: 215 Days and 18 Hours
Core Tip
Core tip: Obesity is unquestionably one of the biggest health challenges the modern world will face this century. It has vast effects on systemic function including cardiovascular disease, metabolic dysfunction and chronic inflammation. All of these factors have a great impact on kidney function, and current data indicate a significant correlation between obesity and kidney disease because of irregular immune activation, altered renal hemodynamics and metabolic mediator signaling. This review focuses on the most recent findings that have begun to elucidate the relationship between obesity and its effect on the kidneys.