Silent diabetic nephropathy

doi:10.5527/wjn.v3.i1.6

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Nephrol. Feb 6, 2014; 3(1): 6-15
Published online Feb 6, 2014. doi: 10.5527/wjn.v3.i1.6

Silent diabetic nephropathy

Katia López-Revuelta, Patricia Peña Galdo, Ramona Stanescu, Leticia Parejo, Carmen Guerrero, Elia Pérez-Fernández

Katia López-Revuelta, Patricia Peña Galdo, Leticia Parejo, Unidad de Nefrología, Hospital Universitario Fundación Alcorcón, 28922 Madrid, Spain

Ramona Stanescu, Carmen Guerrero, Unidad de Anatomía Patológica, Hospital Universitario Fundación Alcorcón, 28922 Madrid, Spain

Elia Pérez-Fernández, Unidad de Investigación, Hospital Universitario Fundación Alcorcón, 28922 Madrid, Spain

Author contributions: López-Revuelta K, Peña Galdo P contributed equally to this work; López-Revuelta K designed the research; Stanescu R revised the kidney biopsies; Parejo L contributed to the data collection and bibliography revision; Guerrero C diagnosed most of the kidney biopsies; Pérez-Fernández E, López-Revuelta K analyzed the data; López-Revuelta K, Pérez-Fernández E, Peña Galdo P, Parejo L wrote the paper.

Correspondence to: Katia López-Revuelta, MD, PhD, Unidad de Nefrología, Hospital Universitario Fundación Alcorcón, Calle Budapest, 1, 28922 Madrid, Spain. k.lopez@senefro.org

Telephone: +34-639205228 Fax: +34-91-6219975

Received: July 8, 2013
Revised: October 14, 2013
Accepted: November 1, 2013
Published online: February 6, 2014
Processing time: 200 Days and 6.4 Hours

Core Tip

Core tip: There are other forms of presentation of diabetic nephropathy (DN), in addition to progressive proteinuria, that can result in renal insufficiency. In some cases, DN is diagnosed in advanced stages, without previous suspicion of this diagnosis. The clinical course can be atypical, and the time of evolution of diabetes mellitus can be short. Not all the factors that play a role in the evolution of DN have been elucidated. Our findings suggest that in patients with chronic kidney disease secondary to DN, a previous history of cardiovascular disease and HbA1c less than 7%, are negative prognostic factors for renal function.