Tbahriti HF, Meknassi D, Moussaoui R, Messaoudi A, Zemour L, Kaddous A, Bouchenak M, Mekki K. Inflammatory status in chronic renal failure: The role of homocysteinemia and pro-inflammatory cytokines. World J Nephrol 2013; 2(2): 31-37 [PMID: 24175263 DOI: 10.5527/wjn.v2.i2.31]
Corresponding Author of This Article
Khedidja Mekki, Professor, Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences de la Nature et de la Vie, Université d’Oran, Oran 31100, Algérie. khmekki@hotmail.com
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Hadja Fatima Tbahriti, Malika Bouchenak, Khedidja Mekki, Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences de la Nature et de la Vie, Université d’Oran, Oran 31100, Algérie
Djamel Meknassi, Abbou Kaddous, Service de Néphrologie, Etablissement Hospitalier Universitaire (EHU) d’Oran, Oran 31037, Algérie
Rachid Moussaoui, Amar Messaoudi, Service de Biochimie, Etablissement Hospitalier Universitaire (EHU) d’Oran, Oran 31037, Algérie
Lakhdar Zemour, Service d’épidémiologie, Etablissement Hospitalier Universitaire (EHU) d’Oran 31037, Oran 31037, Algérie
Author contributions: Tbahriti HF performed the majority of experiments and wrote the manuscript; Mekki K designed the study and wrote the manuscript; Meknassi D and Kaddous A performed the recruitment of patients with chronic renal failure and provided the samples collection; Moussaoui R and Messaoudi A contributed to analysis; Zemour L performed the statistical analysis; Bouchenak M wrote the manuscript.
Correspondence to: Khedidja Mekki, Professor, Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences de la Nature et de la Vie, Université d’Oran, Oran 31100, Algérie. khmekki@hotmail.com
Telephone: +213-41-581944 Fax: +213-41-581944
Received: February 25, 2013 Revised: April 27, 2013 Accepted: May 1, 2013 Published online: May 6, 2013 Processing time: 101 Days and 7.8 Hours
Core Tip
Core tip: Chronic inflammation is highly prevalent in patients with chronic renal failure (CRF). The aim of this study was to evaluate determinants of inflammatory markers in CRF patients. One hundred fifty four CRF patients were divided into 6 groups according to the National Kidney Foundation classification. Tumor necrosis factor-α, interleukin-1β, interleukin-6 values were elevated in hemodialysis (HD) and peritoneal dialysis (PD) patients compared to the other groups of CRF patients. Compared to others stages of CRF patients, total homocysteine, C-reactive protein, ferritin and fibrinogen were increased in HD and PD patients while; transferrin was decreased only in PD. CRF was associated with an enhanced inflammatory reaction existing already at primary stages. This situation was aggravated by the progression disease and dialysis procedure.
