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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Jun 25, 2025; 14(2): 103039
Published online Jun 25, 2025. doi: 10.5527/wjn.v14.i2.103039
Published online Jun 25, 2025. doi: 10.5527/wjn.v14.i2.103039
Advances in the pathophysiology and treatment of focal segmental glomerulosclerosis: The importance of a timely and tailored approach
Guido Gembillo, Domenico Santoro, Unit of Nephrology and Dialysis, AOU "G. Martino", University of Messina, Messina 98125, Sicilia, Italy
Concetto Sessa, Unit of Nephrology and Dialysis, P.O. Maggiore "Nino Baglieri", Ragusa 97100, Sicilia, Italy
Co-corresponding authors: Guido Gembillo and Concetto Sessa.
Author contributions: Gembillo G, Sessa C, and Santoro D contributed equally to the design and implementation of the paper and to the writing of the manuscript; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guido Gembillo, MD, PhD, Assistant Professor, Unit of Nephrology and Dialysis, AOU "G. Martino", University of Messina, Via Consolare Valerian 1, Messina 98125, Sicilia, Italy. ggembillo@gmail.com
Received: November 18, 2024
Revised: January 14, 2025
Accepted: January 21, 2025
Published online: June 25, 2025
Processing time: 154 Days and 16.3 Hours
Revised: January 14, 2025
Accepted: January 21, 2025
Published online: June 25, 2025
Processing time: 154 Days and 16.3 Hours
Core Tip
Core Tip: Focal and segmental glomerulosclerosis is currently considered a histologic pattern encompassing several clinicopathologic entities. Its incidence is increasing worldwide. The rising prevalence is likely due to improved diagnosis and recognition of the disease, combined with a better understanding of the pathophysiology of podocyte damage and the development of therapeutics targeting the mediators underlying this clinicopathologic condition.