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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Mar 25, 2025; 14(1): 99802
Published online Mar 25, 2025. doi: 10.5527/wjn.v14.i1.99802
Published online Mar 25, 2025. doi: 10.5527/wjn.v14.i1.99802
Current role of biomarkers in the initiation and weaning of kidney replacement therapy in acute kidney injury
Kanwalpreet Sodhi, Department of Critical Care, Deep Hospital, Ludhiana 141002, Punjab, India
Gunjan Chanchalani, Department of Critical Care Medicine, Karamshibhai Jethabhai Somaiya Hospital and Research Centre, Mumbai 400022, India
Niraj Tyagi, Department of Critical Care Medicine, Sir Ganga Ram Hospital, New Delhi 110060, Delhi, India
Co-corresponding authors: Kanwalpreet Sodhi and Gunjan Chanchalani.
Author contributions: Sodhi K and Chanchalani G made the detailed tables encompassing the studies on biomarkers; Sodhi K and Tyagi N conceptualized the topic for discussion; Sodhi K, Chanchalani G and Tyagi N helped in literature search and writing the manuscript; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kanwalpreet Sodhi, DA, DNB, MBBS, Doctor, Department of Critical Care, Deep Hospital, Model Town, Ludhiana 141002, Punjab, India.
Received: July 30, 2024
Revised: October 16, 2024
Accepted: November 12, 2024
Published online: March 25, 2025
Processing time: 173 Days and 15.3 Hours
Revised: October 16, 2024
Accepted: November 12, 2024
Published online: March 25, 2025
Processing time: 173 Days and 15.3 Hours
Core Tip
Core Tip: Routinely, > 50% of patients with acute kidney injury in intensive care require kidney replacement therapy (KRT). However, there are no clearcut guiding parameters on timing of initiation or weaning from KRT. Biomarkers have a promising role in initiation of KRT and can be used in decision-making for weaning from KRT. In this narrative review we summarize the individual roles of biomarkers and the supportive literature.