Marrapu S, Kumar R. Transition from acute kidney injury to chronic kidney disease in liver cirrhosis patients: Current perspective. World J Nephrol 2025; 14(1): 102381 [DOI: 10.5527/wjn.v14.i1.102381]
Corresponding Author of This Article
Ramesh Kumar, MD, Department of Gastroenterology, All India Institute of Medical Sciences, Phulwari Sharif, Patna 801507, India. docrameshkr@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Nephrol. Mar 25, 2025; 14(1): 102381 Published online Mar 25, 2025. doi: 10.5527/wjn.v14.i1.102381
Transition from acute kidney injury to chronic kidney disease in liver cirrhosis patients: Current perspective
Sudheer Marrapu, Ramesh Kumar
Sudheer Marrapu, Ramesh Kumar, Department of Gastroenterology, All India Institute of Medical Sciences, Patna 801507, India
Author contributions: Marrapu S analyzed the data and wrote the manuscript; Kumar R designed the study and wrote the manuscript; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors have no conflict-of-interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ramesh Kumar, MD, Department of Gastroenterology, All India Institute of Medical Sciences, Phulwari Sharif, Patna 801507, India. docrameshkr@gmail.com
Received: October 16, 2024 Revised: December 22, 2024 Accepted: January 11, 2025 Published online: March 25, 2025 Processing time: 96 Days and 16.2 Hours
Core Tip
Core Tip: In liver cirrhosis patients, acute kidney injury (AKI) frequently progresses to chronic kidney disease (CKD) through an intermediary stage known as acute kidney disease. This progression is driven by maladaptive repair processes, such as tubular cell cycle arrest and fibrosis, and exacerbated by cirrhosis-related hemodynamic and neurohormonal changes. Early detection of this AKI-to-CKD transition is crucial, and novel biomarkers and innovative imaging techniques, such as renal elastography, may present promising avenues for risk assessment and diagnosis. Integrating these tools into clinical practice, alongside targeted antifibrotic therapies and oxidative stress modulation, presents a promising strategy for managing renal complications in cirrhosis patients.
