Editorial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Mar 25, 2025; 14(1): 101861
Published online Mar 25, 2025. doi: 10.5527/wjn.v14.i1.101861
Hepatorenal syndrome: Paving a pathway from a fatal condition to an opportunity to preserve kidney function
Fernando M Gonzalez
Fernando M Gonzalez, Department of Nephrology, Faculty of Medicine, Universidad de Chile, Santiago 7500922, Chile
Author contributions: Gonzalez FM did all work; the author read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: The author declares no conflict of interest in publishing the manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fernando M Gonzalez, MD, Full Professor, Department of Nephrology, Faculty of Medicine, Universidad de Chile, Avenida Salvador 486, Providencia, Santiago 7500922, Chile. fgonzalf@uc.cl
Received: September 30, 2024
Revised: November 12, 2024
Accepted: December 2, 2024
Published online: March 25, 2025
Processing time: 113 Days and 15.5 Hours
Core Tip

Core Tip: Hepatorenal syndrome involves low glomerular filtration rate, hypotension, renin-angiotensin axis activation, decreased water clearance, hyponatremia, and minimal urinary sodium excretion, similar to prerenal acute kidney injury. Notably, liver grafts from these patients can recover function more rapidly than those from other ischemic conditions. Experimental findings suggest potential therapeutic strategies and underscore the need for further research to understand the mechanisms of hepatorenal syndrome and explore possible treatments.