Observational Study
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World J Nephrol. Mar 25, 2025; 14(1): 101480
Published online Mar 25, 2025. doi: 10.5527/wjn.v14.i1.101480
Distressing symptoms and health-related quality of life in patients with chronic kidney disease
Maysoon Abdalrahim, Manal Al-Sutari
Maysoon Abdalrahim, School of Nursing, The University of Jordan, Amman 11942, Jordan
Manal Al-Sutari, Department of Acute and Chronic Care Nursing, Al-Ahliyya Amman University, Amman 19111, Jordan
Co-first authors: Maysoon Abdalrahim and Manal Al-Sutari.
Author contributions: Abdalrahim M and Al-Sutari M contribute equally to this study as co-first authors; Abdalrahim M conceptualized the study, designed the methodology, and critically reviewed the final manuscript; Al-Sutari M analyzed the data and contributed to the discussion section and drafted the manuscript; Both authors have agreed to be accountable for their contributions and ensure the accuracy and integrity of the final manuscript.
Institutional review board statement: The study protocol priorities voluntary participant and non-compromised care, as approved by the Institutional Review Board (IRB) at The University of Jordan (IRB No. PMs.19.6).
Informed consent statement: Informed consent was obtained from all participants and data privacy was ensured. Data collection adhered to the principles of the Declaration of Helsinki for Human Ethics and the Consent to Participate. Measures were taken to minimize participant discomfort and ensure confidentiality and security in accordance with the ethical guidelines.
Conflict-of-interest statement: All authors declare no potential conflicts of interest with respect to the research, authorship, or publication of the study.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: The data supporting the findings of this study are available upon request from the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Manal Al-Sutari, PhD, Associate Professor, Department of Acute and Chronic Care Nursing, Al-Ahliyya Amman University, Al-Saro, Al-Salt, Amman 19111, Jordan. m.satari@ammanu.edu.jo
Received: September 15, 2024
Revised: November 29, 2024
Accepted: January 7, 2025
Published online: March 25, 2025
Processing time: 126 Days and 15.3 Hours
Core Tip

Core Tip: This study examines distressing symptoms (DS) and their effect on health-related quality of life (HRQOL) in 140 patients with chronic kidney disease (CKD). The Edmonton Symptom Assessment Scale and the Short Form-36 were used. The results reveal that tiredness and worse well-being are the most severe symptoms. Physical health scores (48.50) are notably lower than mental health scores (58.24). Negative correlations exist between DS (e.g., depression, tiredness) and HRQOL, emphasizing the need for tailored symptom management. The study highlights the suboptimal HRQOL in CKD patients and recommends interdisciplinary care and further research for effective symptom management strategies.