Relationship of lupus nephritis and pregnancy: A narrative review

doi:10.5527/wjn.v13.i4.99700

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Dec 25, 2024 (publication date) through Nov 8, 2024

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Nephrol. Dec 25, 2024; 13(4): 99700
Published online Dec 25, 2024. doi: 10.5527/wjn.v13.i4.99700

Relationship of lupus nephritis and pregnancy: A narrative review

Tabassum Elahi, Saima Ahmed, Muhammed Mubarak

Tabassum Elahi, Saima Ahmed, Department of Nephrology, Sindh Institute of Urology and Transplantation, Karachi 74200, Sindh, Pakistan

Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Transplantation, Karachi 74200, Sindh, Pakistan

Author contributions: Elahi T, Ahmed S, and Mubarak M contributed equally to the conception and study design. They performed relevant research, participated in primary and final drafting, and read and approved the final manuscript.

Conflict-of-interest statement: No conflict of interest to disclose.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Muhammed Mubarak, FCPS, Professor, Department of Histopathology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drmubaraksiut@yahoo.com

Received: July 28, 2024
Revised: October 22, 2024
Accepted: October 29, 2024
Published online: December 25, 2024
Processing time: 101 Days and 21.8 Hours

Core Tip

Core Tip: Pregnancy in women with lupus, particularly lupus nephritis (LN), carries an increased risk of adverse outcomes. Women with active LN at conception are at a high risk of poor maternal and fetal outcomes. Pre-conception evaluation is essential to ensure proper planning for optimizing medical regimens, discontinuing teratogenic agents, and treating active disease. Women with prior LN can have successful pregnancies, but a multidisciplinary approach with close monitoring is essential. This narrative review aims to provide a comprehensive update on the complex interaction between LN and pregnancy, offering insights to guide clinical practice and future research in this field.