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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Dec 25, 2024; 13(4): 98932
Published online Dec 25, 2024. doi: 10.5527/wjn.v13.i4.98932
Published online Dec 25, 2024. doi: 10.5527/wjn.v13.i4.98932
Clinical course and outcome of adult patients with primary focal segmental glomerulosclerosis with kidney function loss on presentation
Nazarul Hassan Jafry, Sarfraz Sarwar, Tajammul Waqar, Department of Nephrology, Sindh Institute of Urology and Transplantation, Karachi 74200, Sindh, Pakistan
Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Trans
Author contributions: Jafry NH and Sarwar S conceived and designed the study; Jafry NH, Sarwar S, Waqar T, and Mubarak M contributed significantly and equally to the preparation of the manuscript, participated in primary and final drafting, and performed the research; Mubarak M critically reviewed and finalized the draft; All of the authors read and approved the final version of the manuscript to be published.
Institutional review board statement: The study was reviewed and approved by the Sindh Institute of Urology and Transplantation (Pakistan).
Informed consent statement: All study participants or their legal guardians provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: The dataset and related documents are available from the first author at drjafry12@gmail.com.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Muhammed Mubarak, MD, Full Professor, Department of Histopa
Received: July 9, 2024
Revised: September 28, 2024
Accepted: October 21, 2024
Published online: December 25, 2024
Processing time: 120 Days and 20.8 Hours
Revised: September 28, 2024
Accepted: October 21, 2024
Published online: December 25, 2024
Processing time: 120 Days and 20.8 Hours
Core Tip
Core Tip: Focal segmental glomerulosclerosis is a common glomerular disease that typically presents with nephrotic syndrome. It often presents with kidney function loss and generally signifies a poor prognosis. We previously showed that kidney function loss at presentation is not necessarily associated with poor outcomes. This study further corroborates these findings and suggests that treatment of such patients can improve outcomes.