Stepanova N. Probiotic interventions in peritoneal dialysis: A review of underlying mechanisms and therapeutic potentials. World J Nephrol 2024; 13(4): 98719 [DOI: 10.5527/wjn.v13.i4.98719]
Corresponding Author of This Article
Natalia Stepanova, DSc, PhD, Academic Research, Chief Doctor, Full Professor, Department of Nephrology and Dialysis, State Institution “O.O. Shalimov National Scientific Center of Surgery and Transplantology of the National Academy of Medical Science of Ukraine", Heroes of Sevastopol 30, Kyiv 03680, Ukraine. nmstep88@gmail.com
Research Domain of This Article
Medicine, General & Internal
Article-Type of This Article
Opinion Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Nephrol. Dec 25, 2024; 13(4): 98719 Published online Dec 25, 2024. doi: 10.5527/wjn.v13.i4.98719
Probiotic interventions in peritoneal dialysis: A review of underlying mechanisms and therapeutic potentials
Natalia Stepanova
Natalia Stepanova, Department of Nephrology and Dialysis, State Institution “O.O. Shalimov National Scientific Center of Surgery and Transplantology of the National Academy of Medical Science of Ukraine", Kyiv 03680, Ukraine
Natalia Stepanova, Department of Nephrology, Medical Center “Nephrocenter”, Kyiv 03057, Ukraine
Author contributions: Stepanova N is the sole contributor to the article; Stepanova N has read and approved the final manuscript.
Conflict-of-interest statement: Dr. Stepanova has nothing to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Natalia Stepanova, DSc, PhD, Academic Research, Chief Doctor, Full Professor, Department of Nephrology and Dialysis, State Institution “O.O. Shalimov National Scientific Center of Surgery and Transplantology of the National Academy of Medical Science of Ukraine", Heroes of Sevastopol 30, Kyiv 03680, Ukraine. nmstep88@gmail.com
Received: July 3, 2024 Revised: September 18, 2024 Accepted: October 22, 2024 Published online: December 25, 2024 Processing time: 126 Days and 17.2 Hours
Core Tip
Core Tip: One essential strategy for optimizing peritoneal dialysis (PD) outcomes may involve exploring probiotic interventions to modulate the intestinal microbiome. Recent research highlights altered gut microbiota in PD patients and their impact on inflammation, residual kidney function, and risks of peritonitis, technique failure, and cardiovascular disease. Probiotics could enhance intestinal defenses, regulate immune responses, and manage inflammation, potentially benefiting PD patients. Despite the limited data on probiotics for this patient cohort, exploring their use may represent a new approach to improving patients’ clinical outcomes and the sustainability of dialysis, with further research required to uncover their full potential and limitations.
