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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Dec 25, 2023; 12(5): 159-167
Published online Dec 25, 2023. doi: 10.5527/wjn.v12.i5.159
Published online Dec 25, 2023. doi: 10.5527/wjn.v12.i5.159
The correlation of spot urinary protein-to-creatinine ratio with 24-h urinary protein excretion in various glomerulopathies
Amber Raza, Ejaz Ahmed, Department of Nephrology, Sindh Institute of Urology and Transplantation, Sindh, Karachi 74200, Pakistan
Syed Haider Nawaz, Rahma Rashid, Muhammed Mubarak, Department of Pathology, Sindh Institute of Urology and Transplantation, Sindh, Karachi 74200, Pakistan
Author contributions: Raza A and Ahmed E contributed equally to this work; Raza A, Nawaz SH, Rashid R, Ahmed E, and Mubarak M designed the research study; Raza A, Nawaz SH and Rashid R performed the research; Raza A, Ahmed E, and Mubarak M analyzed the data and wrote the manuscript; All authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Sindh Institute of Urology and Transplantation (Pakistan).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: The dataset and related documents are available from the corresponding author at [dramber88@gmail.com]. Consent was not obtained but the presented data are anonymized and risk of identification is low.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Muhammed Mubarak, MD, Professor, Department of Pathology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, DFMC, Sindh, Karachi 74200, Pakistan. drmubaraksiut@yahoo.com
Received: August 5, 2023
Peer-review started: August 5, 2023
First decision: September 19, 2023
Revised: September 21, 2023
Accepted: October 23, 2023
Article in press: October 23, 2023
Published online: December 25, 2023
Processing time: 138 Days and 22.3 Hours
Peer-review started: August 5, 2023
First decision: September 19, 2023
Revised: September 21, 2023
Accepted: October 23, 2023
Article in press: October 23, 2023
Published online: December 25, 2023
Processing time: 138 Days and 22.3 Hours
Core Tip
Core Tip: The quantitation of proteinuria is of particular importance in the diagnosis and management of glomerulonephritides. The measurement of 24-h urinary protein excretion is the gold standard. However, it is cumbersome, time-consuming, and inconvenient for patients. The measurement of urine protein-to-creatinine ratio (uPCR) is the most popular alternative. Numerous studies have been conducted on the correlation of these two methods with conflicting results. We assessed the correlation and the degree of agreement between the two methods. We conclude that uPCR shows poor correlation and poor agreement with 24-h proteinuria. It must be interpreted with caution in an unselected group of glomerulopathies.