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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Mar 25, 2023; 12(2): 21-28
Published online Mar 25, 2023. doi: 10.5527/wjn.v12.i2.21
Published online Mar 25, 2023. doi: 10.5527/wjn.v12.i2.21
Kidney stone matrix proteins: Role in stone formation
Armando Luis Negri, Department of Physiology and Biophysics, Universidad del Salvador, Instituto de Investigaciones Metabólicas, Buenos Aires 1012, Argentina
Francisco Rodolfo Spivacow, Department of Nephrology, Instituto de Investigaciones Metabólicas , Buenos Aires 1012, Argentina
Author contributions: Negri AL and Spivacow FR performed article design, literature review, and manuscript writing and final edition; Negri AL and Spivacow FR contributed equally to this work.
Conflict-of-interest statement: Both authors declare no conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Armando Luis Negri, FACP, MD, Academic Editor, Professor, Department of Physiology and Biophysics, Universidad del Salvador, Instituto de Inves
Received: October 18, 2022
Peer-review started: October 18, 2022
First decision: December 26, 2022
Revised: January 18, 2023
Accepted: March 17, 2023
Article in press: March 17, 2023
Published online: March 25, 2023
Processing time: 153 Days and 17.3 Hours
Peer-review started: October 18, 2022
First decision: December 26, 2022
Revised: January 18, 2023
Accepted: March 17, 2023
Article in press: March 17, 2023
Published online: March 25, 2023
Processing time: 153 Days and 17.3 Hours
Core Tip
Core Tip: Several urinary proteins have been found in kidney stone matrix. In vitro and in vivo studies have shown that they have an important role in various processes of calcium oxalate crystallization. Many of them have other functions in modulating oxidative stress, immune response, and inflammation that could also influence stone formation. Yet, the exact role of these kidney stone matrix proteins needs to be established through more studies comparing urinary stone proteomics between stone formers and non-stone formers.