Observational Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Jul 25, 2022; 11(4): 127-138
Published online Jul 25, 2022. doi: 10.5527/wjn.v11.i4.127
Concordance between bio-impedance analysis and clinical score in fluid-status assessment of maintenance haemodialysis patients: A single centre experience
Kamiti Muchiri, Joshua K Kayima, Elijah N Ogola, Seth McLigeyo, Sally W Ndung’u, Samuel K Kabinga
Kamiti Muchiri, Joshua K Kayima, Seth McLigeyo, Clinical Medicine and Therapeutics, University of Nairobi, Nairobi +254, Kenya
Elijah N Ogola, Department of Clinical Medicine and Therapeutics, University of Nairobi, Nairobi +254, Kenya
Sally W Ndung’u, Department of Public Health, University of Nairobi, Nairobi +254, Kenya
Samuel K Kabinga, East African Kidney Institute, University of Nairobi, Nairobi +254, Kenya
Author contributions: Muchiri K, Kayima JK, Ogola EN, McLigeyo S, and Kabinga SK designed and coordinated the study; Muchiri K performed all the study procedures; Ndung’u SW analysed and interpreted the data; Muchiri K, Kabinga SK, and Ndung’u SW wrote the manuscript; and all authors approved the final version of this article.
Institutional review board statement: The study was reviewed by the Kenyatta National Hospital/University of Nairobi Scientific and Ethical Review Committee and approved under proposal number P822/012/2018 prior to initiation.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Data can be availed on request.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Samuel K Kabinga, MBChB, MD, Doctor, East African Kidney Institute, University of Nairobi, P.O. Box 30197, Nairobi +254, Kenya. kabingas@yahoo.com
Received: June 19, 2021
Peer-review started: June 19, 2021
First decision: July 31, 2021
Revised: September 19, 2021
Accepted: June 21, 2022
Article in press: June 21, 2022
Published online: July 25, 2022
Processing time: 395 Days and 21.4 Hours
Core Tip

Core Tip: Bio-impedance analysis (BIA) has been validated as an accurate and reliable tool for determining fluid status in chronic kidney disease (CKD) patients but is not widely available in low-income settings. In this study we assess how a clinical score (CS) compares with BIA in this population for possible use as a low-cost substitute where BIA is not available. Patients with a CS score greater than 4 were considered to have fluid overload (FO), and detected using this parameter in 58.75% of patients. CSs of ≤ 4 represented no FO, and represented 41.25% of patients. The CS had a sensitivity of 63% and a specificity of 78% in making a diagnosis of FO compared with BIA, which was used as the reference in patients with CKD on maintenance haemodialysis.