Juarez-Villa JD, Zepeda-Quiroz I, Toledo-Ramírez S, Gomez-Johnson VH, Pérez-Allende F, Garibay-Vega BR, Rodríguez Castellanos FE, Moguel-González B, Garcia-Cruz E, Lopez-Gil S. Exploring kidney biopsy findings in congenital heart diseases: Insights beyond cyanotic nephropathy. World J Nephrol 2024; 13(1): 88972 [PMID: 38596269 DOI: 10.5527/wjn.v13.i1.88972]
Corresponding Author of This Article
Salvador Lopez-Gil, MD, Associate Professor, Department of Nephrology, Instituto Nacional de Cardiología Ignacio Chavez, 1 Juan Badiano, Mexico City 14080, Mexico. salvadorlgil@gmail.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jose Daniel Juarez-Villa, Iván Zepeda-Quiroz, Sebastián Toledo-Ramírez, Victor Hugo Gomez-Johnson, Francisco Pérez-Allende, Brian Ricardo Garibay-Vega, Francisco E Rodríguez Castellanos, Bernardo Moguel-González, Edgar Garcia-Cruz, Salvador Lopez-Gil
Jose Daniel Juarez-Villa, Iván Zepeda-Quiroz, Sebastián Toledo-Ramírez, Victor Hugo Gomez-Johnson, Francisco Pérez-Allende, Brian Ricardo Garibay-Vega, Francisco E Rodríguez Castellanos, Bernardo Moguel-González, Salvador Lopez-Gil, Department of Nephrology, Instituto Nacional de Cardiología Ignacio Chavez, Mexico City 14080, Mexico
Edgar Garcia-Cruz, Congenital Heart Disease, Instituto Nacional de Cardiología Ignacio Chavez, Mexico City 14080, Mexico
Author contributions: Juarez-Villa JD, Zepeda-Quiroz I, Toledo-Ramírez S, Gomez-Johnson VH, Pérez-Allende F, Garibay-Vega BR, Rodríguez Castellanos FE, Moguel-González B, Garcia-Cruz E, and Lopez-Gil S contributed to design of the study, data analysis, drafting and critical revision and editing, and final approval of the final version.
Institutional review board statement: The need for study approval was waived by the local Ethics Committee of The National Institute of Cardiology.
Informed consent statement: The need for informed consent was waived by the local Ethics Committee of The National Institute of Cardiology.
Conflict-of-interest statement: None of the authors have any conflict-of-interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Salvador Lopez-Gil, MD, Associate Professor, Department of Nephrology, Instituto Nacional de Cardiología Ignacio Chavez, 1 Juan Badiano, Mexico City 14080, Mexico. salvadorlgil@gmail.com
Received: October 18, 2023 Peer-review started: October 18, 2023 First decision: December 7, 2023 Revised: December 20, 2023 Accepted: January 15, 2024 Article in press: January 15, 2024 Published online: March 25, 2024 Processing time: 155 Days and 12.3 Hours
ARTICLE HIGHLIGHTS
Research background
There is limited information available about the etiology of chronic kidney disease in patients with congenital heart disease today due to advanced surgeries providing an increased life expectancy, therefore it’s truly important to delay the onset of kidney replacement therapy.
Research motivation
There is a growing population of patients with congenital heart disease and chronic kidney disease which is an area of opportunity to evaluate the causes of this pathology and the impact on it’s treatment.
Research objectives
To determine that there may be other glomerulopathies in this population and treating them may possibly delay the onset of kidney replacement therapy.
Research methods
We conducted a retrospective analysis of information from patients with congenital heart disease who underwent kidney biopsy.
Research results
We determined that there may be other glomerulopathies in which treatment could be given. It would be appropriate to determine in a larger population if the number of other glomerulopathies different from focal segmental glomerulosclerosis (FSGS) is higher and if treatment really delays kidney replacement therapy.
Research conclusions
Chronic kidney disease in congenital heart disease is not always due to hypoxic damage that leads to FSGS.
Research perspectives
Clinical trials that can clarify who truly benefits from biopsy and enable follow-up to perform interventions that could delay renal replacement therapy.
