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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
FGF23 and inflammation
Usama A A Sharaf El Din, Mona M Salem, Dina O Abdulazim, Department of Nephrology, School of Medicine, Cairo University, Nasr City, Cairo 11759, Egypt
Author contributions: The three authors equally shared in writing and revising the letter.
Conflict-of-interest statement: Authors have nothing to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Usama AA Sharaf El Din, MD, Professor, Department of Nephrology, School of Medicine, Cairo University, 58th Abbas El Akkad St., Nasr City, Cairo 11759, Egypt. usamaaas@gmail.com
Telephone: +20-11-11333800 Fax: +20-22-2753890
Received: October 15, 2016
Peer-review started: October 19, 2016
First decision: November 14, 2016
Revised: November 29, 2016
Accepted: December 13, 2016
Article in press: December 14, 2016
Published online: January 6, 2017
Processing time: 73 Days and 20.3 Hours
Peer-review started: October 19, 2016
First decision: November 14, 2016
Revised: November 29, 2016
Accepted: December 13, 2016
Article in press: December 14, 2016
Published online: January 6, 2017
Processing time: 73 Days and 20.3 Hours
Abstract
Systemic inflammation is a recognized feature in chronic kidney disease (CKD). The role of systemic inflammation in the pathogenesis of vascular calcification was recently settled. FGF23 was recently accused as a direct stimulus of systemic inflammation. This finding explains the strong association of FGF23 to vascular calcification and increased mortality among CKD.
Core tip: In this letter, the authors confirm the direct offending role of FGF23 in the pathogenesis of vascular calcification and increased mortality among chronic kidney disease patients.