Deodhare KG, Pathak N. Hypertension and associated complications in pregnant women with chronic kidney disease. World J Nephrol 2024; 13(4): 100680 [DOI: 10.5527/wjn.v13.i4.100680]
Corresponding Author of This Article
Nabadwip Pathak, DM, MD, Assistant Professor, Department of Nephrology, All India Institute of Medical Sciences, Bathinda 151001, Punjab, India. nabapthk88@gmail.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Nephrol. Dec 25, 2024; 13(4): 100680 Published online Dec 25, 2024. doi: 10.5527/wjn.v13.i4.100680
Hypertension and associated complications in pregnant women with chronic kidney disease
Kirti Girish Deodhare, Nabadwip Pathak
Kirti Girish Deodhare, Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Bathinda 151001, Punjab, India
Nabadwip Pathak, Department of Nephrology, All India Institute of Medical Sciences, Bathinda 151001, Punjab, India
Author contributions: Deodhare KG conducted the literature review, interpreted the data, created the artwork, and drafted the original manuscript; Pathak N supervised the study and made critical revisions; Deodhare KG and Pathak N conceptualized and designed the study; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nabadwip Pathak, DM, MD, Assistant Professor, Department of Nephrology, All India Institute of Medical Sciences, Bathinda 151001, Punjab, India. nabapthk88@gmail.com
Received: August 22, 2024 Revised: September 30, 2024 Accepted: October 28, 2024 Published online: December 25, 2024 Processing time: 76 Days and 15.4 Hours
Abstract
The growing incidence of obesity and the rising trend of increased age during pregnancy have led to a high number of pregnant women with chronic kidney disease (CKD). Chronic hypertension is commonly associated with CKD and is not only the result of renal damage but is also the cause of declining renal function. Pregnancy and its unique physiological adaptations are affected by a decrease in the filtration capacity of the kidneys. Preeclampsia is a disorder of the vascular endothelium and is exacerbated by endothelial dysfunction resulting from CKD. Blood pressure targets must be strictly maintained owing to overlapping disease pathogenesis and to minimize cardiovascular damage. Moreover, preexisting renal dysfunction poses a challenge in identifying superimposed preeclampsia, which alters the management strategies in pregnancy. Fetal outcomes in patients with CKD are considerably affected by the presence of hypertension. This review is expected to aid in developing a focused and individualized treatment plan for hypertension in pregnant women with CKD to improve pregnancy outcomes and preserve postpartum renal function.
Core Tip: Hypertension is a strong determinant of pregnancy outcomes in patients with chronic kidney disease. Hence, the success of pregnancy depends largely on the prevention of hypertension and the effective management of patients who develop hypertension and its associated complications. Preeclampsia can lead to a decline in renal function and can worsen preexisting kidney damage. A tailored approach to blood pressure management in these patients can help salvage both the pregnancy and the kidneys.
