Platt E, Klootwijk E, Salama A, Davidson B, Robertson F. Literature review of the mechanisms of acute kidney injury secondary to acute liver injury. World J Nephrol 2022; 11(1): 13-29 [PMID: 35117976 DOI: 10.5527/wjn.v11.i1.13]
Corresponding Author of This Article
Esther Platt, FRCS (Gen Surg), MA, MBBS, Surgeon, Department of Surgery and Interventional Science, University College London, Royal Free Campus, University College London, No. 9 Floor Royal Free Hospital, Pond Street, London NW3 2QG, United Kingdom. esther.platt.20@ucl.ac.uk
Research Domain of This Article
Surgery
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Nephrol. Jan 25, 2022; 11(1): 13-29 Published online Jan 25, 2022. doi: 10.5527/wjn.v11.i1.13
Literature review of the mechanisms of acute kidney injury secondary to acute liver injury
Esther Platt, Enriko Klootwijk, Alan Salama, Brian Davidson, Francis Robertson
Esther Platt, Brian Davidson, Francis Robertson, Division of Surgery and Interventional Science, University College London, London NW3 2QG, United Kingdom
Enriko Klootwijk, Alan Salama, Department of Renal Medicine, University College London, London NW3 2PF, United Kingdom
Author contributions: Platt E wrote the manuscript which was reviewed and edited by all authors; all authors contributed to the design of the manuscript and reviewed the final manuscript prior to submission.
Conflict-of-interest statement: No author has any conflict of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Esther Platt, FRCS (Gen Surg), MA, MBBS, Surgeon, Department of Surgery and Interventional Science, University College London, Royal Free Campus, University College London, No. 9 Floor Royal Free Hospital, Pond Street, London NW3 2QG, United Kingdom. esther.platt.20@ucl.ac.uk
Received: February 25, 2021 Peer-review started: February 25, 2021 First decision: May 3, 2021 Revised: May 4, 2021 Accepted: December 25, 2021 Article in press: December 25, 2021 Published online: January 25, 2022 Processing time: 328 Days and 15.7 Hours
Abstract
People exposed to liver ischaemia reperfusion (IR) injury often develop acute kidney injury and the combination is associated with significant morbidity and mortality. Molecular mediators released by the liver in response to IR injury are the likely cause of acute kidney injury (AKI) in this setting, but the mediators have not yet been identified. Identifying the mechanism of injury will allow the identification of therapeutic targets which may modulate both liver IR injury and AKI following liver IR injury.
Core Tip: Acute kidney injury (AKI) following liver injury is likely to be mediated by circulating molecules. Further investigation is required to identify therapeutic targets to modify liver injury and AKI and reduce the morbidity and mortality associated with this condition.
