Correa-Costa M, Amano MT, Câmara NOS. Cytoprotection behind heme oxygenase-1 in renal diseases. World J Nephrol 2012; 1(1): 4-11 [PMID: 24175236 DOI: 10.5527/wjn.v1.i1.4]
Corresponding Author of This Article
Niels Olsen Saraiva Câmara, MD, Full Professor, Head, Laboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, Cidade Universitária, Av.Prof. Lineu Prestes, 173, 05508-000, São Paulo, Brazil. niels@icb.usp.br
Article-Type of This Article
Editorial
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Matheus Correa-Costa, Mariane Tami Amano, Niels Olsen Saraiva Câmara, Laboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, 05508-000, São Paulo, Brazil
Author contributions: Correa-Costa M and Amano MT wrote the manuscript; Câmara NOS wrote and corrected the manuscript; Correa-Costa M and Amano MT contributed equally to the work.
Supported by FAPESP (07/07139-3 and 09/54474-8), CAPES/PNPD, INCT Complex Fluids and CNPq
Correspondence to: Niels Olsen Saraiva Câmara, MD, Full Professor, Head, Laboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, Cidade Universitária, Av.Prof. Lineu Prestes, 173, 05508-000, São Paulo, Brazil. niels@icb.usp.br
Telephone: +55-11-30917388 Fax: +55-11-55739652
Received: October 9, 2011 Revised: October 27, 2011 Accepted: December 27, 2011 Published online: February 6, 2012
Abstract
Renal insults are considered a public health problem and are linked to increased rates of morbidity and mortality worldwide. The heme oxygenase (HO) system consists of evolutionary specialized machinery that degrades free heme and produces carbon monoxide, biliverdin and free iron. In this sense, the inducible isoform HO-1 seems to develop an important role and is widely studied. The reaction involved with the HO-1 molecule provides protection to injured tissue, directly by reducing the toxic heme molecule and indirectly by the release of its byproducts. The up regulation of HO-1 enzyme has largely been described as providing antioxidant, antiapoptotic, anti-inflammatory and immunomodulatory properties. Several works have explored the importance of HO-1 in renal diseases and they have provided consistent evidence that its overexpression has beneficial effects in such injuries. So, in this review we will focus on the role of HO-1 in kidney insults, exploring the protective effects of its up regulation and the enhanced deleterious effects of its inhibition or gene deletion.
