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Shi S, Zhang K, Tian N, Jin Z, Liu K, Huang L, Tian X, Cao C, Zhang Y, Jiang Y. Spectroscopic techniques combined with chemometrics for rapid detection of food adulteration: Applications, perspectives, and challenges. Food Res Int 2025; 211:116459. [PMID: 40356185 DOI: 10.1016/j.foodres.2025.116459] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/18/2025] [Revised: 03/19/2025] [Accepted: 04/15/2025] [Indexed: 05/15/2025]
Abstract
Food adulteration is an important threat to food safety and can be difficult to detect. Some analytical methods are complex and difficult to meet the needs of large numbers of samples. In this study, we introduced the application of six spectroscopic techniques (NIR, FTIR, HSI, Raman, UV-Vis, and FS) and chemometric methods in common food adulteration (powdered food, meat, honey, drink, edible oil, and dairy product) over the last three years. We introduced the consequences of food adulteration, the principles, advantages, and limitations of spectroscopic techniques, spectral data preprocessing and key wavelength selection methods, chemometrics methods, dataset division methods, and evaluation methods for models. Moreover, it provided a perspective for the future application of spectroscopic techniques in food adulteration. The results showed that linear chemometric methods were still the main method used by many researchers, which may limit the application potential of spectroscopic techniques. Therefore, deep learning-based chemometrics methods and their interpretability should be further explored in food adulteration. Secondly, data fusion and ensemble models based on multiple spectroscopic techniques and chemometrics can further improve the accuracy of the models. Future research should select appropriate spectroscopic techniques based on food type and spectroscopic principles, and consider portable technical solutions wherever possible to improve the application scenarios of spectroscopic techniques.
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Affiliation(s)
- Shijie Shi
- College of Agriculture, Yangtze University, Hubei, China; MARA Key Laboratory of Sustainable Crop Production in the Middle Reaches of the Yangtze River, Yangtze University, China.
| | - Kaidi Zhang
- College of Plant Science & Technology, Huazhong Agricultural University, Hubei, China
| | - Nina Tian
- College of Agriculture, Yangtze University, Hubei, China
| | - Zhaoqiang Jin
- College of Agriculture, Yangtze University, Hubei, China; MARA Key Laboratory of Sustainable Crop Production in the Middle Reaches of the Yangtze River, Yangtze University, China
| | - Ke Liu
- College of Agriculture, Yangtze University, Hubei, China; Tasmanian Institute of Agriculture, University of Tasmania, Launceston, Australia
| | - Liying Huang
- College of Agriculture, Yangtze University, Hubei, China; MARA Key Laboratory of Sustainable Crop Production in the Middle Reaches of the Yangtze River, Yangtze University, China
| | - Xiaohai Tian
- College of Agriculture, Yangtze University, Hubei, China; MARA Key Laboratory of Sustainable Crop Production in the Middle Reaches of the Yangtze River, Yangtze University, China
| | - Cougui Cao
- College of Plant Science & Technology, Huazhong Agricultural University, Hubei, China; Shuangshui Shuanglü Institute, Huazhong Agricultural University, Wuhan, Hubei, China
| | - Yunbo Zhang
- College of Agriculture, Yangtze University, Hubei, China; MARA Key Laboratory of Sustainable Crop Production in the Middle Reaches of the Yangtze River, Yangtze University, China
| | - Yang Jiang
- College of Plant Science & Technology, Huazhong Agricultural University, Hubei, China; Shuangshui Shuanglü Institute, Huazhong Agricultural University, Wuhan, Hubei, China.
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Tsai HJ, Wu CF, Li SS, Chen JJ, Hsieh CJ, Chen CC, Wang SL, Chen ML, Wu MT. Sex-specific association of co-exposures to melamine and phthalates in children with their early renal injury. ENVIRONMENTAL POLLUTION (BARKING, ESSEX : 1987) 2025; 374:126206. [PMID: 40210160 DOI: 10.1016/j.envpol.2025.126206] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/13/2024] [Revised: 03/21/2025] [Accepted: 04/02/2025] [Indexed: 04/12/2025]
Abstract
Studies concerning the effect of co-exposure to melamine and phthalates on kidney function in children are rare. Thus, this study examines the above-mentioned relationship and their sex-different effect. Whether the exposure of the two chemicals from their mothers, when children were in the womb during the third trimester, affected renal injury markers in children afterwards is also examined. This study was from Taiwan Maternal and Infant Cohort Study cohort established in October 2012 to enroll third-trimester pregnant mothers up to May 2015. Their offspring were subsequently recruited between 2016 and 2020 as our study children. One-spot urine specimens were collected from both pregnant mothers (2012-2015) and study children (2016-2020) for the simultaneous measurement of melamine and 11 phthalate metabolites. Daily intakes of melamine and five phthalates, including DEHP (di-2-ethylhexylphthalate), DiBP (Dibutyl phthalate), DnBP (Di-n-butyl phthalate), BBzP (Butyl benzyl phthalate), and DEP (Diethyl phthalate), were estimated using a creatinine excretion-based model in both study children and their mothers. Two early markers of renal injury, microalbumin and N-acetyl-beta-D-glucosaminidas (NAG), were measured in urine samples of study children (2016-2020). A total of 552 eligible children were studied, with a mean age of 4 years. We found that boys in the highest quartile of estimated melamine intake (≥0.68 μg/kg/day) had significantly higher urine ACR levels and in the highest quartile of estimated phthalate intake of DEHP (≥5.36 μg/kg/day), DEP (≥0.89 μg/kg/day), and DiBP (≥1.19 μg/kg/day) had significantly higher urine NAG levels when compared to the combined three lowest quartile ones as comparison groups. No significant associations were found between their mothers' phthalates and melamine intake during the third trimester and urine ACR and NAG in children. We conclude that children (particularly boys) with high co-exposure of melamine and certain phthalate chemicals among children have increased early markers of kidney injury.
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Affiliation(s)
- Hui-Ju Tsai
- Department of Family Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Family Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
| | - Chia-Fang Wu
- Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Research Center for Environmental Changes, Academia Sinica, Taipei, Taiwan
| | - Sih-Syuan Li
- Ph.D. Program in Environmental and Occupational Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
| | - Jia-Jen Chen
- Ph.D. Program in Environmental and Occupational Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
| | - Chia-Jung Hsieh
- Department of Public Health, Tzu Chi University, Hualien, Taiwan
| | - Chu-Chih Chen
- Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan
| | - Shu-Li Wang
- National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan
| | - Mei-Lien Chen
- Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
| | - Ming-Tsang Wu
- Department of Family Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Ph.D. Program in Environmental and Occupational Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
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Darvishi P, Mirzaee-Ghaleh E, Ramedani Z, Karami H, Wilson AD. A novel approach for identifying melamine adulteration in powdered milk with E-nose and AI. Food Chem Toxicol 2025; 202:115521. [PMID: 40334969 DOI: 10.1016/j.fct.2025.115521] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/24/2025] [Revised: 04/24/2025] [Accepted: 05/05/2025] [Indexed: 05/09/2025]
Abstract
Dairy products are exceptionally nutritious and a key component of our diet. They are utilized in a wide range of food industries due to their significance. However, being highly popular and valuable, they are among the most common products subject to adulteration. Melamine is a chemical compound deliberately added to various food products. It is used to artificially increase the apparent protein content in milk, milk powder, pet food, and other foods. In this study, pure milk powder along with 12 different types of adulterated samples (with melamine content of 1, 2, 3, 4, and 5 ppm) in both dry and wet forms was analyzed using an electronic nose equipped with 8 metal oxide sensors to detect adulteration patterns. Principal Component Analysis (PCA), discriminant analysis (DA), and Support Vector Machine (SVM) methods were employed to analyze sensor response patterns and classification. Quantitative Descriptive Analysis (QDA) yielded a precision of 99.5 %, while Multi-Discriminant Analysis (MDA) achieved a precision of 98.5 %. Therefore, it appears that electronic nose technology with metal oxide sensors, along with chemometric methods, can be a truly effective tool for the rapid detection and classification of pure milk powder from adulterated materials.
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Affiliation(s)
- Pouya Darvishi
- Department of Mechanical Engineering of Biosystems, Razi University, Kermanshah, 67156-85421, Iran
| | - Esmaeil Mirzaee-Ghaleh
- Department of Mechanical Engineering of Biosystems, Razi University, Kermanshah, 67156-85421, Iran.
| | - Zeynab Ramedani
- Department of Mechanical Engineering of Biosystems, Razi University, Kermanshah, 67156-85421, Iran
| | - Hamed Karami
- Department of Petroleum Engineering, Knowledge University, Erbil, 44001, Iraq
| | - Alphus Dan Wilson
- Pathology Department, Southern Hardwoods Laboratory, Center for Forest Health & Disturbance, Forest Genetics & Ecosystems Biology, Southern Research Station, USDA Forest Service, 432 Stoneville Road, Stoneville, MS, 38776, USA
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Li G, Liu C, Qiu S, Wei L, Cao L, Wang K, Wang X, Lin H, Sui J. From non-affinity to high-affinity: Rapid preparation of nanobodies utilizing high-precision alphafold and structural-interaction analysis for detection of enrofloxacin in marine fish. JOURNAL OF HAZARDOUS MATERIALS 2025; 488:137394. [PMID: 39889601 DOI: 10.1016/j.jhazmat.2025.137394] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/04/2024] [Revised: 01/13/2025] [Accepted: 01/24/2025] [Indexed: 02/03/2025]
Abstract
Traditional antibody preparation methods rely on animal immunization and experimental screening, often requiring 3-6 months, which cannot meet the urgent demands for antibodies in environmental emergencies or contamination events. Herein, a rapid antibody preparation method was proposed to transform anti-macromolecule nanobodies into high-affinity anti-small molecule (enrofloxacin) nanobodies, based on the high-precision predictive capabilities of AlphaFold, integrated with structural and interaction analysis. The high-precision prediction capability of AlphaFold ensured the accuracy of nanobody structural analysis and targeted modification. Binding structure design enabled the antigen and antibody to adopt an optimal binding conformation. Interaction analysis provided guidance for targeted modifications and served as a tool for evaluating the results. Molecular docking results revealed that the template nanobodies, which initially couldn't dock with enrofloxacin, formed 3-5 noncovalent bonds after modification. Bio-layer interferometry (BLI) assays demonstrated that the equilibrium dissociation constant (KD) of the modified nanobodies ranged from 5.56 ± 0.34 nM to 94.73 ± 4.35 nM, with half-maximal inhibitory concentration (IC50) between 231.9 and 3293.6 ng/mL. Based on the modified nanobodies and BLI platform, the detection of enrofloxacin in marine fish was achieved with a limit of detection (LOD) as low as 59.97 μg/kg. In summary, this study provided a novel perspective for the rapid nanobody preparation, showing significant potential in food safety and environmental monitoring.
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Affiliation(s)
- Guoqiang Li
- State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong 266100, China
| | - Chang Liu
- State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong 266100, China
| | - Shuo Qiu
- State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong 266100, China
| | - Lin Wei
- State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong 266100, China
| | - Limin Cao
- State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong 266100, China
| | - Kaiqiang Wang
- State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong 266100, China
| | - Xiudan Wang
- State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong 266100, China
| | - Hong Lin
- State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong 266100, China
| | - Jianxin Sui
- State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong 266100, China.
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Ham JH, Lee YJ, Lee SS, Kim HY. Food Fraud in Plant-Based Proteins: Analytical Strategies and Regulatory Perspectives. Foods 2025; 14:1548. [PMID: 40361630 PMCID: PMC12071692 DOI: 10.3390/foods14091548] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/07/2025] [Revised: 04/25/2025] [Accepted: 04/26/2025] [Indexed: 05/15/2025] Open
Abstract
Food fraud and adulteration have been persistent issues affecting food supply chains throughout history. They intensify in parallel with the continuous growth in the global food market. Plant-based proteins, which are recognized as sustainable alternatives, face increased food fraud risks because of disparities in the cost of raw materials and complex processing methods. Despite these challenges, most efforts toward preventing food fraud and developing detection technologies have largely focused on animal-based products, with limited attention given to plant-based proteins. This comprehensive review systematically examines the characteristics of major plant protein sources and explores documented instances of food fraud (e.g., ingredient substitution, adulteration with lower-cost alternatives, and mislabeling) within this sector. Furthermore, we discuss key analytical techniques in detecting food fraud, including chromatography, DNA analysis, spectroscopy, and imaging-based approaches, examining their applications and effectiveness. A systematic literature review was conducted using structured search strategies across Scopus, Web of Science, and PubMed, covering publications from 2010 to 2025 and incorporating keywords related to plant-based proteins, food fraud, adulteration, and authentication, thereby ensuring methodological rigor and comprehensive coverage. This study provides a foundational framework to strengthen food fraud prevention strategies and uphold the integrity of the expanding plant-based protein market.
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Affiliation(s)
| | | | | | - Hae-Yeong Kim
- Department of Food Science and Biotechnology, Kyung Hee University, Yongin 17104, Republic of Korea; (J.-H.H.); (Y.-J.L.); (S.-S.L.)
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Campbell JA, Petersen CE. Analysis of children's kidney stones and comparison to canine kidney stones: Both resulting from ingesting adulterated food products. Toxicol Appl Pharmacol 2025; 495:117190. [PMID: 39647512 DOI: 10.1016/j.taap.2024.117190] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/30/2024] [Revised: 12/02/2024] [Accepted: 12/03/2024] [Indexed: 12/10/2024]
Abstract
Kidney stones resulting from ingestion of melamine-tainted food products were originally detected in dogs and cats in 2004 and 2007. Nephroliths were removed at necropsy from dogs that had died from acute kidney injury in Asia in 2004. Samples of these were submitted to our laboratories for analysis. The presence of a mixed s-triazine matrix comprising melamine, cyanuric acid, and ammelide, but no detectable ammeline was found in the canine stone samples we analyzed. The unusual and unique green coloration of these stones was attributed to the presence of biliverdin. The techniques developed in the canine study were applied to the analysis of human kidney stones. In 2008, high levels of melamine were detected in some infant formula and other liquid and powdered milk products originating from China. Human kidney stones, resulting from this type of contamination, were obtained from children, and analyzed using mass spectral techniques. The results indicated the presence of melamine, ammeline, uric acid, but no ammelide. No green color was observed, thereby eliminating biliverdin. Careful monitoring of food additives is warranted to prevent future problems in both animals and humans.
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Das U, Gayan A, Biswas R. A highly sensitive facile plasmonic scheme for assessment of melamine in raw milk. ANALYTICAL METHODS : ADVANCING METHODS AND APPLICATIONS 2025; 17:552-561. [PMID: 39663989 DOI: 10.1039/d4ay01764a] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/13/2024]
Abstract
This work presents two novel devices with a microcontroller and two different light sensors, namely, Light Dependent Resistor (LDR) and Ambient Light Sensor (ALS), which can provide a quantitative output from the colorimetric variations of citrate capped borohydride reduced silver nanoparticles (AgNPs) and citrate capped gold nanoparticles (AuNPs) upon addition of melamine adulterated milk. The limit of detection (LOD) of the LDR setup with AgNPs and AuNPs was found to be 1.24 ppm and 1.68 ppm, respectively, and the corresponding recovery rates were 92.86% and 88.57%, respectively. The device fabricated with the ALS with AgNPs displayed a recovery rate of 97.14% with a LOD value of 0.64 ppm.
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Affiliation(s)
- Upama Das
- Applied Optics and Photonics Research Laboratory, Department of Physics, Tezpur University, Napaam, Tezpur, Assam-784028, India.
| | - Abhilash Gayan
- Applied Optics and Photonics Research Laboratory, Department of Physics, Tezpur University, Napaam, Tezpur, Assam-784028, India.
| | - Rajib Biswas
- Applied Optics and Photonics Research Laboratory, Department of Physics, Tezpur University, Napaam, Tezpur, Assam-784028, India.
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8
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Choi G, Xun X, Bennett DH, Meeker JD, Morello-Frosch R, Sathyanarayana S, Schantz SL, Trasande L, Watkins D, Pellizzari ED, Li W, Kannan K, Woodruff TJ, Buckley JP. Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort. ENVIRONMENT INTERNATIONAL 2025; 195:109227. [PMID: 39740267 PMCID: PMC11826381 DOI: 10.1016/j.envint.2024.109227] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/26/2024] [Revised: 12/16/2024] [Accepted: 12/18/2024] [Indexed: 01/02/2025]
Abstract
Melamine, its analogues, and aromatic amines (AAs) were commonly detected in a previous study of pregnant women in the Environmental influences on Child Health Outcomes (ECHO) Cohort. While these chemicals have identified toxicities, little is known about their influences on fetal development. We measured these chemicals in gestational urine samples in 3 ECHO cohort sites to assess associations with birth outcomes (n = 1,231). We estimated beta coefficients and 95% confidence intervals (CIs) using adjusted linear mixed models with continuous dilution-standardized concentrations (log2 transformed and scaled by interquartile range, IQR) or binary indicators for detection. As secondary analyses, we repeated analyses using categorical outcomes. Forty-one of 45 analytes were detected in at least one sample, with > 95 % detection of melamine, cyanuric acid, ammelide, and aniline. Higher melamine concentration was associated with longer gestational age (β^ per IQR increase of log2-transformed: 0.082 [95 % CI: -0.012, 0.177]; 2nd vs 1st tertile: 0.173 [-0.048, 0.394]; 3rd vs 1st tertile: 0.186 [-0.035, 0.407]). Similarly in secondary analyses using categorical outcomes, an IQR increase in log2(melamine) was associated with 1.22 [0.99, 1.50] higher odds of post-term (>40 & ≤42 weeks) as compared to full-term (≥38 & ≤40 weeks). Several AAs were associated with birthweight and gestational length, with the direction of associations varying by AA. Some stronger associations were observed in females. Our findings suggest melamine and its analogs and AAs may influence gestational length and birthweight.
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Affiliation(s)
- Giehae Choi
- Department of Environmental Health and Engineering, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, United States
| | - Xiaoshuang Xun
- Department of Epidemiology, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, United States
| | - Deborah H Bennett
- Department of Public Health Sciences, University of California Davis, Medical Sciences 1C, Davis, CA 95616, United States
| | - John D Meeker
- Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, United States
| | - Rachel Morello-Frosch
- School of Public Health and Department of Environmental Science, Policy and Management, University of California, Berkeley, Mulford Hall, 130 Hilgard Way, Berkeley, CA 94720, United States
| | - Sheela Sathyanarayana
- Department of Pediatrics and Environmental and Occupational Health Sciences, University of Washington, 3980 15th Ave NE, Seattle, WA 98195, United States; Seattle Children's Research Institute, 1900 9th Ave, Seattle, WA 98101, United States
| | - Susan L Schantz
- Beckman Institute for Advanced Science and Technology and Department of Comparative Biosciences, University of Illinois Urbana-Champaign, Urbana, IL 61802, United States
| | - Leonardo Trasande
- Departments of Pediatrics and Population Health, NYU Grossman School of Medicine, and NYU Wagner School of Pediatrics, 550 1st Ave., New York, NY 10016, United States
| | - Deborah Watkins
- Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, United States
| | - Edo D Pellizzari
- Fellow Program, Research Triangle Institute, 3040 E Cornwallis Rd, Research Triangle Park, NC 27709, United States
| | - Wenlong Li
- Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201, United States
| | - Kurunthachalam Kannan
- Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201, United States
| | - Tracey J Woodruff
- Department of Obstetrics, Gynecology, and Reproductive Sciences and the Philip R. Lee Institute for Health Policy Studies, University of California San Francisco, 550 16th Street, Box 0132, San Francisco, CA 94158, United States.
| | - Jessie P Buckley
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, CB#7435, Chapel Hill, NC 27599-7435, United States.
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Liu Y, Zhang Q, Zhao L, Hua L, Xu K, Shi Y, Chen S, Zhao H, Zhu H, Wang S. Unraveling the contribution of melamine tableware for human internal exposure to melamine and its derivatives: Insights from crossover and biomonitoring studies. THE SCIENCE OF THE TOTAL ENVIRONMENT 2024; 955:176971. [PMID: 39419215 DOI: 10.1016/j.scitotenv.2024.176971] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/08/2024] [Revised: 10/13/2024] [Accepted: 10/14/2024] [Indexed: 10/19/2024]
Abstract
Melamine tableware can release melamine in daily-use; however, currently there is insufficient evidence to support whether the amount released could pose human exposure risk. We therefore conducted two studies, one is 8-day randomized crossover trial involving 27 volunteers who used melamine and stainless-steel tableware in turn (n = 648) and the other is cross-sectional study including 113 college students and 200 residents (n = 313) to further provide population-based evidence. The crossover study results showed that using melamine tableware could promote urinary concentrations of melamine, cyanuric acid (CYA), and ammelide by 42.1 %, 66.9 %, and 36.2 %, respectively. In the biomonitoring survey, students who are more accessible to melamine tableware in the canteen had 1.47-fold higher median urinary concentrations of melamine-related compounds than that of common residents (393 vs 267 nmol/L, p < 0.01). Additionally, positive associations between exposure to melamine and an oxidative stress indicator, 8-oxo-7,8-dihydroguanine (β = 1.13, 95 % CI: 0.32, 1.94), and CYA and 8-hydroxy-2'-deoxyguanosine (β = 0.87, 95 % CI: 0.22, 1.53) were observed in students (p < 0.01), indicating long-term chronic exposure to these chemicals may induce molecular damage to nucleic acids. Our findings provide compelling evidence that frequent use of melamine tableware continues to be a potential threat to human health.
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Affiliation(s)
- Yarui Liu
- College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China
| | - Qiuyue Zhang
- MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China
| | - Leicheng Zhao
- MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China
| | - Liting Hua
- MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China
| | - Ke Xu
- MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China
| | - Yumeng Shi
- MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China
| | - Shucong Chen
- MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China
| | - Hongzhi Zhao
- MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China
| | - Hongkai Zhu
- MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China.
| | - Shuo Wang
- Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300350, China.
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Han M, Hlaing MM, Stoddart PR, Greene GW. Self-Assembled Lubricin (PRG-4)-Based Biomimetic Surface-Enhanced Raman Scattering Sensor for Direct Droplet Detection of Melamine in Undiluted Milk. BIOSENSORS 2024; 14:591. [PMID: 39727856 DOI: 10.3390/bios14120591] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 11/05/2024] [Revised: 11/26/2024] [Accepted: 11/29/2024] [Indexed: 12/28/2024]
Abstract
Surface-enhanced Raman scattering (SERS) is a powerful optical sensing platform that amplifies the target signals by Raman scattering. Despite SERS enabling a meager detection limit, even at the single-molecule level, SERS also tends to equally enhance unwanted molecules due to the non-specific binding of noise molecules in clinical samples, which complicates its use in complex samples such as bodily fluids, environmental water, or food matrices. To address this, we developed a novel non-fouling biomimetic SERS sensor by self-assembling an anti-adhesive, anti-fouling, and size-selective Lubricin (LUB) coating on gold nanoparticle (AuNP) functionalized glass slide surfaces via a simple drop-casting method. Compared to a conventional AuNPs-SERS substrate, the biomimetic SERS meets the requirements of simple preparation and enables direct droplet detection without any sample pre-treatment. Atomic force microscopy was used to confirm the self-assembled Lubricin coating on the AuNP surface, acting as an anti-fouling and size-selective protection layer. A series of Raman spectra were collected using melamine as the target analyte, which was spiked into 150 mM NaCl solution or undiluted milk. It was demonstrated that the LUB coating effectively prevents the detrimental fouling generated by the proteins and fats in milk, ensuring the clear detection of melamine. Our sensor showed high selectivity and could detect melamine in milk at concentrations as low as 1 ppm. Given that the EU/US legal limit for melamine in food is 2.5 ppm, this sensor offers a promising, cost-effective solution for routine screening and has potential applications for detecting food adulteration in the food safety, environmental monitoring, aquaculture, and biomedical fields.
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Affiliation(s)
- Mingyu Han
- Commonwealth Scientific and Industrial Research Organization (CSIRO), Agriculture and Food, 671 Sneydes Road, Werribee, VIC 3030, Australia
| | - Mya Myintzu Hlaing
- Commonwealth Scientific and Industrial Research Organization (CSIRO), Agriculture and Food, 671 Sneydes Road, Werribee, VIC 3030, Australia
| | - Paul R Stoddart
- School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Hawthorn, VIC 3122, Australia
| | - George W Greene
- Department of Biochemistry and Chemistry, La Trobe University, Bundoora, VIC 3086, Australia
- La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3086, Australia
- School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC 3086, Australia
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11
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Ko CH, Kong WY, Kabiso AC, Chiu WH, Tadesse AB, Hong C, Wu CF, Lin HH. Portable SpectroChip-Based Immunoassay Platform for Rapid and Accurate Melamine Quantification in Urine Samples. TOXICS 2024; 12:870. [PMID: 39771085 PMCID: PMC11679044 DOI: 10.3390/toxics12120870] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 11/03/2024] [Revised: 11/25/2024] [Accepted: 11/28/2024] [Indexed: 01/11/2025]
Abstract
Growing concerns about the health risks of melamine adulteration in food products highlight the urgent need for reliable detection methods. However, the long-term effects of chronic low-level melamine exposure remain inadequately explored. This study introduces THE ONE InstantCare platform, a portable immunoassay analyzer integrating a SpectroChip-based spectral processing unit (SPU) with lateral flow immunoassay (LFIA) for sensitive and accurate quantification of melamine in human urine. This platform provides a cost-effective, rapid, and user-friendly point-of-care (POC) solution for melamine detection. Analytical evaluations across eight melamine concentrations (0-100 parts per billion, ppb) achieved a limit of detection (LOD) of 1.91 ppb. Validation with 24 human urine samples demonstrated strong concordance with liquid chromatography-mass spectrometry (LC-MS), yielding an intraclass correlation coefficient (ICC) of 0.9220, a Pearson correlation coefficient of 0.9389, and 95% agreement in Bland-Altman analysis. High reproducibility was observed, with an intraday coefficient of variation (CV) of 6.53% and acceptable interday CV values, while interference studies confirmed reliability in the presence of common biological substances. By delivering results in approximately 10 min, THE ONE InstantCare platform significantly reduces analysis time compared to LC-MS, which typically requires several hours. This novel platform enhances food safety surveillance and advances human health risk assessments, particularly for evaluating melamine-linked kidney damage. Its versatility and robust performance make it a promising tool for environmental monitoring and clinical diagnostics, enabling the detection of diverse biomarkers with high sensitivity and reproducibility.
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Affiliation(s)
- Cheng-Hao Ko
- Graduate Institute of Automation and Control, National Taiwan University of Science and Technology, Taipei 106, Taiwan; (W.-Y.K.); (A.C.K.); (W.-H.C.); (A.B.T.)
| | - Wei-Yi Kong
- Graduate Institute of Automation and Control, National Taiwan University of Science and Technology, Taipei 106, Taiwan; (W.-Y.K.); (A.C.K.); (W.-H.C.); (A.B.T.)
| | - Abel Chernet Kabiso
- Graduate Institute of Automation and Control, National Taiwan University of Science and Technology, Taipei 106, Taiwan; (W.-Y.K.); (A.C.K.); (W.-H.C.); (A.B.T.)
| | - Wei-Huai Chiu
- Graduate Institute of Automation and Control, National Taiwan University of Science and Technology, Taipei 106, Taiwan; (W.-Y.K.); (A.C.K.); (W.-H.C.); (A.B.T.)
| | - Ashenafi Belihu Tadesse
- Graduate Institute of Automation and Control, National Taiwan University of Science and Technology, Taipei 106, Taiwan; (W.-Y.K.); (A.C.K.); (W.-H.C.); (A.B.T.)
| | | | - Chia-Fang Wu
- Research Center for Environmental Changes, Academia Sinica (AS), Taipei 115, Taiwan;
- Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan;
| | - Hung-Hsun Lin
- Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan;
- Center of Teaching & Research, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 812, Taiwan
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12
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Tsao CW, Yang ZY. Utilization of microdroplets as optical lenses for surface-enhanced Raman spectroscopy (SERS) enhancement on localized silver nanoparticle-decorated porous silicon substrates. LAB ON A CHIP 2024; 24:5184-5192. [PMID: 39301932 DOI: 10.1039/d4lc00550c] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 09/22/2024]
Abstract
Surface-enhanced Raman spectroscopy (SERS) is a widely used analytical technique known for its high sensitivity and broad applicability. Despite its potential, SERS faces challenges related to detection sensitivity and reproducibility. This study proposes an innovative method to enhance SERS performance by employing water microdroplets as optical lenses on localized silver nanoparticle-decorated porous silicon (LocAg-PS) substrates. The hydrophobic nature of the LocAg-PS substrate not only ensures precise positioning of the microdroplet lenses on the silver nanoparticle grafted pad (AgNP pad) but also forms a plano-convex-like microdroplet lens for the focusing of the excitation laser and the collection of scattered light. Experimental results demonstrate that using microdroplet lenses enhances the SERS signal intensity and reproducibility, providing a rapid and cost-effective solution for advanced SERS analysis.
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Affiliation(s)
- Chia-Wen Tsao
- Department of Mechanical Engineering, National Central University, No. 300, Zhongda Rd., Zhongli District, Taoyuan City 320, Taiwan.
- Department of Medical Research, Cathay General Hospital, No. 280, Renai Rd. Sec. 4, Taipei City, 106, Taiwan
| | - Zi-Yi Yang
- Department of Mechanical Engineering, National Central University, No. 300, Zhongda Rd., Zhongli District, Taoyuan City 320, Taiwan.
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13
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Perez-Gonzalez C, Garcia-Hernandez C, Garcia-Cabezon C, Rodriguez-Mendez ML, Dias L, Martin-Pedrosa F. Analysis of milk adulteration by means of a potentiometric electronic tongue. J Dairy Sci 2024; 107:9135-9144. [PMID: 39004125 DOI: 10.3168/jds.2024-25140] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/09/2024] [Accepted: 06/20/2024] [Indexed: 07/16/2024]
Abstract
Milk adulteration presents substantial challenges in the food industry, prompting the need for efficient detection methods. This study introduces a potentiometric electronic tongue for rapid and accurate detection of milk adulteration. Using polymeric membranes with various integrated additives, the electronic tongue distinguished between different milk types and detected common adulterants. Experimental results demonstrated its effectiveness in discriminating raw, pasteurized, and medicated cow milk, as well as goat milk. Moreover, it successfully identified adulterants, such as water and cow milk, in goat milk samples. Chemometric analyses, including principal component analysis and partial least squares regression, correlated sensor responses with traditional milk parameters such as fat, protein, and lactose content with an R2 of up to 0.97 on the validation step. Strong correlations validated the electronic tongue's potential for rapid milk quality assessment. This innovative approach offers a cost-effective, reliable solution for detecting milk adulteration in contrast to current techniques that require numerous time-consuming experiments.
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Affiliation(s)
- C Perez-Gonzalez
- Group UVASENS, Escuela de Ingenierías Industriales, Universidad de Valladolid, 47011 Valladolid, Spain; BioecoUVA Research Institute, Universidad de Valladolid, 47011 Valladolid, Spain
| | - C Garcia-Hernandez
- BioecoUVA Research Institute, Universidad de Valladolid, 47011 Valladolid, Spain; Department of Materials Science, Universidad de Valladolid, 47011 Valladolid, Spain.
| | - C Garcia-Cabezon
- BioecoUVA Research Institute, Universidad de Valladolid, 47011 Valladolid, Spain; Department of Materials Science, Universidad de Valladolid, 47011 Valladolid, Spain.
| | - M L Rodriguez-Mendez
- Group UVASENS, Escuela de Ingenierías Industriales, Universidad de Valladolid, 47011 Valladolid, Spain; BioecoUVA Research Institute, Universidad de Valladolid, 47011 Valladolid, Spain
| | - L Dias
- Centro de Investigação de Montanha (CIMO), ESA, Instituto Politécnico de Bragança, 5301 Bragança, Portugal
| | - F Martin-Pedrosa
- BioecoUVA Research Institute, Universidad de Valladolid, 47011 Valladolid, Spain; Department of Materials Science, Universidad de Valladolid, 47011 Valladolid, Spain
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14
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Shen C, Wang R, Nawazish H, Wang B, Cai K, Xu B. Machine vision combined with deep learning-based approaches for food authentication: An integrative review and new insights. Compr Rev Food Sci Food Saf 2024; 23:e70054. [PMID: 39530613 DOI: 10.1111/1541-4337.70054] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/12/2024] [Revised: 09/27/2024] [Accepted: 10/13/2024] [Indexed: 11/16/2024]
Abstract
Food fraud undermines consumer trust, creates economic risk, and jeopardizes human health. Therefore, it is essential to develop efficient technologies for rapid and reliable analysis of food quality and safety for food authentication. Machine vision-based methods have emerged as promising solutions for the rapid and nondestructive analysis of food authenticity and quality. The Industry 4.0 revolution has introduced new trends in this field, including the use of deep learning (DL), a subset of artificial intelligence, which demonstrates robust performance and generalization capabilities, effectively extracting features, and processing extensive data. This paper reviews recent advances in machine vision and various DL-based algorithms for food authentication, including DL and lightweight DL, used for food authenticity analysis such as adulteration identification, variety identification, freshness detection, and food quality identification by combining them with a machine vision system or with smartphones and portable devices. This review explores the limitations of machine vision and the challenges of DL, which include overfitting, interpretability, accessibility, data privacy, algorithmic bias, and design and deployment of lightweight DLs, and miniaturization of sensing devices. Finally, future developments and trends in this field are discussed, including the development of real-time detection systems that incorporate a combination of machine vision and DL methods and the expansion of databases. Overall, the combination of vision-based techniques and DL is expected to enable faster, more affordable, and more accurate food authentication methods.
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Affiliation(s)
- Che Shen
- Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology, Hefei, China
| | - Ran Wang
- Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology, Hefei, China
| | - Hira Nawazish
- Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology, Hefei, China
| | - Bo Wang
- College of Food Science and Technology, Bohai University, Jinzhou, China
| | - Kezhou Cai
- Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology, Hefei, China
| | - Baocai Xu
- Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology, Hefei, China
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15
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Ferreira MM, Marins-Gonçalves L, De Souza D. An integrative review of analytical techniques used in food authentication: A detailed description for milk and dairy products. Food Chem 2024; 457:140206. [PMID: 38936134 DOI: 10.1016/j.foodchem.2024.140206] [Citation(s) in RCA: 3] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/14/2024] [Revised: 06/04/2024] [Accepted: 06/22/2024] [Indexed: 06/29/2024]
Abstract
The use of suitable analytical techniques for the detection of adulteration, falsification, deliberate substitution, and mislabeling of foods has great importance in the industrial, scientific, legislative, and public health contexts. This way, this work reports an integrative review with a current analytical approach for food authentication, indicating the main analytical techniques to identify adulteration and perform the traceability of chemical components in processed and non-processed foods, evaluating the authenticity and geographic origin. This work presents results from a systematic search in Science Direct® and Scopus® databases using the keywords "authentication" AND "food", "authentication," AND "beverage", from published papers from 2013 to, 2024. All research and reviews published were employed in the bibliometric analysis, evaluating the advantages and disadvantages of analytical techniques, indicating the perspectives for direct, quick, and simple analysis, guaranteeing the application of quality standards, and ensuring food safety for consumers. Furthermore, this work reports the analysis of natural foods to evaluate the origin (traceability), and industrialized foods to detect adulterations and fraud. A focus on research to detect adulteration in milk and dairy products is presented due to the importance of these products in the nutrition of the world population. All analytical tools discussed have advantages and drawbacks, including sample preparation steps, the need for reference materials, and mathematical treatments. So, the main advances in modern analytical techniques for the identification and quantification of food adulterations, mainly milk and dairy products, were discussed, indicating trends and perspectives on food authentication.
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Affiliation(s)
- Mariana Martins Ferreira
- Laboratory of Electroanalytical Applied to Biotechnology and Food Engineering (LEABE), Chemistry Institute, Uberlândia Federal University, Major Jerônimo Street, 566, Patos de Minas, MG, 38700-002, Brazil
| | - Lorranne Marins-Gonçalves
- Laboratory of Electroanalytical of Food and Environmental Contaminants (LECAA), Chemistry Institute, Uberlândia Federal University, João Naves de Ávila Street, 2121, 1D block, Santa Mônica, Uberlândia, MG, 38400-902, Brazil
| | - Djenaine De Souza
- Laboratory of Electroanalytical of Food and Environmental Contaminants (LECAA), Chemistry Institute, Uberlândia Federal University, João Naves de Ávila Street, 2121, 1D block, Santa Mônica, Uberlândia, MG, 38400-902, Brazil..
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16
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Shutevska K, Bajatovska AM, Anastasova L, Zhivikj Z, Zafirova Gjorgievska M, Spasikj S, Petreska Ivanovska T, Makreski P, Geskovski N. Rapid quantification models for assessing melamine adulteration in sport nutrition supplements via benchtop and portable NIRS instruments. SPECTROCHIMICA ACTA. PART A, MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 2024; 317:124370. [PMID: 38744225 DOI: 10.1016/j.saa.2024.124370] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/29/2023] [Revised: 04/23/2024] [Accepted: 04/27/2024] [Indexed: 05/16/2024]
Abstract
Sport nutrition supplements (SNS) are vulnerable to adulteration with melamine, artificially augmenting their protein content as determined by conventional assay methodologies. Vibrational spectroscopy techniques are suitable for the detection of adulteration because they allow rapid analysis, require minimal sample preparation, and can perform numerous analyses in a short time. The aim of this study was to develop rapid quantification models for the determination of melamine adulteration in a variety of SNS matrices using NIRS (near-infrared spectroscopy) in combination with multivariate data processing. Moreover, a comparison of benchtop and portable NIR instruments was carried out. Employing a stepwise approach involving OPLS-DA and PLS analysis, matrix discrimination and prediction ability were investigated. The benchtop instrument effectively discriminated among matrices (R2Y = 0.964, Q2 = 0.933), while the portable device, although showing a slightly altered pattern, maintained favorable discrimination capability (R2Y = 0.966, Q2 = 0.931). The quantitative PLS models for each SNS matrix exhibited comparable statistical indicators for both instruments with reasonable errors for melamine content estimation and prediction (RMSEE: 0.3-2.4 %, RMSEP: 0.98-2.99 %). Higher estimation and prediction errors were observed for protein-containing samples in both acquisition modes, probably due to the tendency of protein agglomeration and adhesion to different surfaces, which affects the homogeneity of the powder. Despite data loss due to the narrower spectral range and lower resolution of the portable instrument, all models were found to be suitable for predicting melamine content in sport nutrition supplements.
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Affiliation(s)
- Kristina Shutevska
- Ss Cyril and Methodius University in Skopje, Faculty of Pharmacy, Majka Tereza 47, 1000, Skopje, Republic of North Macedonia.
| | - Ana Marija Bajatovska
- Ss Cyril and Methodius University in Skopje, Faculty of Pharmacy, Majka Tereza 47, 1000, Skopje, Republic of North Macedonia
| | - Liljana Anastasova
- Ss Cyril and Methodius University in Skopje, Faculty of Pharmacy, Majka Tereza 47, 1000, Skopje, Republic of North Macedonia
| | - Zoran Zhivikj
- Ss Cyril and Methodius University in Skopje, Faculty of Pharmacy, Majka Tereza 47, 1000, Skopje, Republic of North Macedonia
| | - Marija Zafirova Gjorgievska
- Ss Cyril and Methodius University in Skopje, Faculty of Pharmacy, Majka Tereza 47, 1000, Skopje, Republic of North Macedonia
| | - Sanja Spasikj
- Center for Public Health - Kumanovo, 11 Oktomvri bb, 1300, Kumanovo, Republic of North Macedonia
| | - Tanja Petreska Ivanovska
- Ss Cyril and Methodius University in Skopje, Faculty of Pharmacy, Majka Tereza 47, 1000, Skopje, Republic of North Macedonia
| | - Petre Makreski
- Ss Cyril and Methodius University in Skopje, Faculty of Natural Sciences and Mathematics, Institute of Chemistry, Arhimedova 5, 1000, Skopje, Republic of North Macedonia
| | - Nikola Geskovski
- Ss Cyril and Methodius University in Skopje, Faculty of Pharmacy, Majka Tereza 47, 1000, Skopje, Republic of North Macedonia.
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17
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Campbell JA, Franz JA, Romanczyk LJ, Wunschel DJ, Metz TO, Petersen CE. An outbreak of renal failure in asian dogs due to s-triazine adulteration of pet food raw material: Analysis of unique, green kidney stones formed as a result. Food Chem Toxicol 2024; 191:114878. [PMID: 39067742 DOI: 10.1016/j.fct.2024.114878] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/27/2024] [Revised: 07/07/2024] [Accepted: 07/21/2024] [Indexed: 07/30/2024]
Abstract
Renoliths were removed at necropsy from dogs that had died from acute kidney injury in Asia in 2004 and submitted to our laboratories for analysis including elemental composition, mass spectrometry, and nuclear magnetic resonance spectroscopy. The presence of a mixed s-triazine matrix comprising melamine, cyanuric acid, and ammelide, but no detectable ammeline, was found in the stone samples we analyzed. The unusual and unique green coloration of these stones was determined to be due to the presence of biliverdin. The occurrence of these green stones distinguished the 2004 incident from another incident in 2007 in the USA and other reported cases. The presence of crystals was reported in renal tubules and collecting ducts in both outbreaks, but no stones were reported in the 2007 incident. This difference suggested a variation in the disease process caused by mixed s-triazine ingestion. Careful monitoring of food additives is warranted to prevent future problems in animals and humans.
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Affiliation(s)
| | - James A Franz
- Pacific Northwest National Laboratory, Richland, WA, USA
| | | | | | - Thomas O Metz
- Pacific Northwest National Laboratory, Richland, WA, USA.
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18
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Alam MNE, Ullah AKMA, Hosen MM, Maksud MA, Khan SR, Akon S, Nahar Q, Jolly F, Quraishi SB. Evaluation of essential and trace metals/metalloids distribution and probable human health risk implications from branded liquid and powder milks available in Dhaka City, Bangladesh. Biometals 2024; 37:859-875. [PMID: 38267777 DOI: 10.1007/s10534-023-00574-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/25/2023] [Accepted: 12/19/2023] [Indexed: 01/26/2024]
Abstract
The processed forms of milk, branded liquid, and power milk available in Dhaka city, the capital of Bangladesh, were investigated for essential and trace metal/metalloids regarding nutritional and human health risk aspects. For this, the potential nutritional contribution, estimated daily intake (EDI) and non-carcinogenic risk for six different life stages with male and female categories, as well as the carcinogenic risk for children and adults of both genders, were addressed. In total, 46 branded liquid and powder milk samples were considered for this analysis employing atomic absorption spectroscopy. The concentration of essential elements showed the trends of K > Ca > Na > Mg > Fe > Zn > Mn > Cu and K > Ca > Na > Mg > Fe > Cu > Mn > Zn for liquid and powder milk samples, respectively, but the potentially hazardous one showed the same trends (Cr > Pb > Hg > As > Cd) for both items. Except for Cr, Hg, and Fe, the elemental compositions of both milk categories differed considerably (< 0.05). Compared to the threshold values for milk samples (liquid and powder), Fe (19% and 27%), Mn (100% and 63%), Cu (0% and 23%), Zn (94% and 0%), Pb (25% and 13%), and Cr (0% and 3%) showed above the permissible limits. The nutrient input was the highest for Ca (27.2% and 18.7%), followed by Mg, K, and Na. The EDI of studied elements was within the daily permissible limit in both the milk category (except age group (≤ 3) and the female category). The non-carcinogenic risk assessment showed that the age groups ≤ 3 for liquid milk and ≤ 3 and 3 < X ≤ 14 with female categories for powder milk exceeded the threshold level (> 1) in the case of Cr, Cd, As, Zn, and Mn. The probable carcinogenic risks indicated an unacceptable risk level (< 1.00E-04) for the ingestion of Cr through powder milk samples for children in male and female categories. Finally, it believes that green cow farming practices and green milk processing technology, as well as continuous monitoring of toxic metals, can limit the ultimate risk worldwide.
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Affiliation(s)
- Md Nur E Alam
- Analytical Chemistry Laboratory, Chemistry Division, Atomic Energy Center Dhaka, Bangladesh Atomic Energy Commission (BAEC), 4-Kazi Nazrul Islam Avenue, Shahbag, Dhaka, 1000, Bangladesh.
| | - A K M Atique Ullah
- Analytical Chemistry Laboratory, Chemistry Division, Atomic Energy Center Dhaka, Bangladesh Atomic Energy Commission (BAEC), 4-Kazi Nazrul Islam Avenue, Shahbag, Dhaka, 1000, Bangladesh
| | - M Mozammal Hosen
- Analytical Chemistry Laboratory, Chemistry Division, Atomic Energy Center Dhaka, Bangladesh Atomic Energy Commission (BAEC), 4-Kazi Nazrul Islam Avenue, Shahbag, Dhaka, 1000, Bangladesh
| | - Md Azizul Maksud
- Analytical Chemistry Laboratory, Chemistry Division, Atomic Energy Center Dhaka, Bangladesh Atomic Energy Commission (BAEC), 4-Kazi Nazrul Islam Avenue, Shahbag, Dhaka, 1000, Bangladesh
| | - Shahidur Rahman Khan
- Analytical Chemistry Laboratory, Chemistry Division, Atomic Energy Center Dhaka, Bangladesh Atomic Energy Commission (BAEC), 4-Kazi Nazrul Islam Avenue, Shahbag, Dhaka, 1000, Bangladesh
| | - Shamima Akon
- Department of Food and Nutrition, College of Home Economics, University of Dhaka (DU), Shahbag, Dhaka, 1000, Bangladesh
| | - Quamrun Nahar
- Department of Endocrine and Metabolic Disorder, Bangladesh Institute of Research and Rehabilitation in Diabetes (BIRDEM), Shahbag, Dhaka, 1000, Bangladesh
| | - Ferdousi Jolly
- Department of Food and Nutrition, College of Home Economics, University of Dhaka (DU), Shahbag, Dhaka, 1000, Bangladesh
| | - Shamshad B Quraishi
- Analytical Chemistry Laboratory, Chemistry Division, Atomic Energy Center Dhaka, Bangladesh Atomic Energy Commission (BAEC), 4-Kazi Nazrul Islam Avenue, Shahbag, Dhaka, 1000, Bangladesh
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19
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Brevett CAS, Cox JA. Intentional Adulteration of Foods with Chemicals: Snapshot for 2009-2022. J Food Prot 2024; 87:100305. [PMID: 38796113 PMCID: PMC11343076 DOI: 10.1016/j.jfp.2024.100305] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/10/2024] [Accepted: 05/20/2024] [Indexed: 05/28/2024]
Abstract
Global occurrences of the intentional adulteration of food with a chemical toxicant culled from the literature and news reports from 2009 to 2022 were analyzed in terms of their ability to cause mass public health harm. A total of 76 intentional adulteration events that involved over 27 chemicals and 16 foods were identified. The chemicals used included pesticides, rat poisons, illicit drugs, and commercial chemicals. A total of 253 deaths and 4,887 illnesses were attributed to intentional adulteration events; there were deaths in 20% and illnesses in 50% of the events. Intentional adulteration during manufacturing, which accounted for 21 events (28%), resulted in 205 deaths (81%) and 3,572 illnesses (73%). Intentional adulteration at the food preparation node, which accounted for 17 events (22%), resulted in 39 deaths (15%) and 387 illnesses (8%). On-farm intentional adulteration, eight events (10%) resulted in 843 illnesses (17%) and no deaths. The perpetrators who were identified generally had legitimate access to the food, although in 63% of the cases studied, the perpetrator was not identified. Economically motivated adulteration and revenge resulted in over 80% of the deaths and illnesses.
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Affiliation(s)
- Carol A S Brevett
- Battelle Memorial Institute, Chemical Security Analysis Center, Department of Homeland Security Science and Technology Directorate, Bldg. E3401, 2nd Floor, 8490 Ricketts Point Road, Aberdeen Proving Ground, Gunpowder, MD, 21010, USA.
| | - Jessica A Cox
- Chemical Security Analysis Center, Department of Homeland Security Science and Technology Directorate, Bldg. E3401, 2nd Floor, 8490 Ricketts Point Road, Aberdeen Proving Ground, Gunpowder, MD, 21010, USA.
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20
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Costa MJ, Sousa I, Pinto Moura A, Teixeira JA, Cunha LM. Food Fraud Conceptualization: An Exploratory Study with Portuguese Consumers. J Food Prot 2024; 87:100301. [PMID: 38740141 DOI: 10.1016/j.jfp.2024.100301] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/27/2023] [Revised: 05/04/2024] [Accepted: 05/07/2024] [Indexed: 05/16/2024]
Abstract
Food fraud refers to deceptive practices conducted for economic gain, and incidents of such fraud are often reported in the media and scientific literature. However, little is known about how European consumers perceive food fraud. To address this gap, a study explored Portuguese consumers' knowledge and perceptions of food fraud using qualitative methods such as free word association and semi-structured interviews. For this research, 340 participants were recruited, providing 911 valid words, classified into categories, major categories, and dimensions. Differences between consumers' previous exposure to food fraud and sociodemographic characteristics were explored. Additionally, other thirty-six participants were selected and interviewed, following a semi-structured guide. Interviews were transcribed, coded, and analyzed using a thematic analysis procedure. The results suggest that Portuguese consumers view food fraud as a morally reprehensible deception and are aware of its causes and impacts. However, not all consumers know the different forms of food fraud or the types of products vulnerable to fraud. Among the most repeated words were "deception", "expiration date", and "falsification". Despite this food fraud awareness, most consumers believed they were not exposed to food fraud and stated that they do not conduct daily practices to reduce exposure to it. Following the chi-square and Mann-Whitney tests, significant differences (p ≤ 0.05) were identified between participants exposed and not exposed to food fraud. The study also found that consumers with higher education and self-reported exposure to food fraud had a better understanding of the issue. This study provides insights for quantitative research on consumer perceptions and beliefs about food fraud to explore further vulnerable food categories and types of food fraud in real-world scenarios.
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Affiliation(s)
- Maria João Costa
- GreenUPorto- Sustainable Agrifood Production Research Centre/INOV4Agro, University of Porto, Porto, Portugal; DGAOT, Faculty of Sciences, University of Porto, Porto, Portugal; Faculty of Nutrition and Food Sciences, University of Porto, Porto, Portugal
| | - Isabel Sousa
- GreenUPorto- Sustainable Agrifood Production Research Centre/INOV4Agro, University of Porto, Porto, Portugal; DGAOT, Faculty of Sciences, University of Porto, Porto, Portugal; CEB - Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal; LABBELS -Associated Laboratory, Braga, Guimarães, Portugal
| | - Ana Pinto Moura
- GreenUPorto- Sustainable Agrifood Production Research Centre/INOV4Agro, University of Porto, Porto, Portugal; DCeT, Universidade Aberta, Porto, Portugal
| | - José A Teixeira
- CEB - Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal; LABBELS -Associated Laboratory, Braga, Guimarães, Portugal
| | - Luís Miguel Cunha
- GreenUPorto- Sustainable Agrifood Production Research Centre/INOV4Agro, University of Porto, Porto, Portugal; DGAOT, Faculty of Sciences, University of Porto, Porto, Portugal.
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21
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Das U, Biswas R, Mazumder N. One-Pot Interference-Based Colorimetric Detection of Melamine in Raw Milk via Green Tea-Modified Silver Nanostructures. ACS OMEGA 2024; 9:21879-21890. [PMID: 38799313 PMCID: PMC11112553 DOI: 10.1021/acsomega.3c09516] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 11/29/2023] [Revised: 03/08/2024] [Accepted: 04/24/2024] [Indexed: 05/29/2024]
Abstract
Detection of melamine has proven to be a challenge, requiring the use of complex analytical techniques. This study introduces an innovative, straightforward one-pot technique for qualitative assessment of the milk adulterant melamine. Originally, silver nanoparticles (AgNPs) were synthesized by utilizing green tea extract, which acted as both a reducing and sensing element. The synthesized AgNPs were characterized using UV-vis spectroscopy, X-ray diffraction, zeta potential, transmission electron microscopy, field emission scanning electron microscopy, and Fourier transform infrared spectroscopy. Melamine, rich in -NH2 groups, interacts with the biopolyphenols of green tea extract through hydrogen bonding. This interaction inhibits the formation of nanoparticles, resulting in a noticeable colorimetric response. The data obtained were confirmed by a standard UV-vis spectrophotometer and validated by the high-performance liquid chromatography technique. The limit of detection achieved by this scheme was quite low, falling below the permissible levels recommended by government bodies, e.g., the Food Safety and Standards Authority of India (FSSAI).
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Affiliation(s)
- Upama Das
- Applied
Optics and Photonics Research Laboratory, Department of Physics, Tezpur University, Tezpur 784028, Assam, India
| | - Rajib Biswas
- Applied
Optics and Photonics Research Laboratory, Department of Physics, Tezpur University, Tezpur 784028, Assam, India
| | - Nirmal Mazumder
- Department
of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India
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22
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Putko P, Romero JA, Kazimierczuk K. A pH-enhanced resolution in benchtop NMR spectroscopy. Analyst 2024; 149:1998-2003. [PMID: 38421293 DOI: 10.1039/d3an02000b] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/02/2024]
Abstract
NMR spectroscopy is one of the most potent methods in analytical chemistry. NMR titration experiments are particularly useful since they measure molecular binding affinities and other concentration-dependent effects. These experiments, however, require a long series of measurements. An alternative to these serial measurements has recently been presented, exploiting a pH (or generally - a concentration) gradient along the NMR tube. The proposed experiment, although efficient, was based on the sensitivity- and hardware-demanding chemical shift imaging (CSI) method. Thus, it is practically limited to high-resolution NMR spectrometers. This paper proposes modifying and adapting the approach to the popular and cost-efficient benchtop NMR machines. Instead of CSI, we use a device that shifts the NMR tube vertically to measure the spectra of different sample volumes, which have different pH values due to the established gradient along the tube. We demonstrate the potential of the method on the test samples of L-tyrosine and 2,6-lutidine, and two real samples from the food industry - an infant formula and an energy drink. The proposed method boosts spectral resolution and allows for the sampling of a broader range of pH values when compared to the original approach.
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Affiliation(s)
- Paulina Putko
- Centre of New Technologies, University of Warsaw, Banacha 2C, 02-097 Warsaw, Poland.
| | - Javier A Romero
- Centre of New Technologies, University of Warsaw, Banacha 2C, 02-097 Warsaw, Poland.
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23
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Everstine KD, Chin HB, Lopes FA, Moore JC. Database of Food Fraud Records: Summary of Data from 1980 to 2022. J Food Prot 2024; 87:100227. [PMID: 38246523 DOI: 10.1016/j.jfp.2024.100227] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/21/2023] [Revised: 01/11/2024] [Accepted: 01/16/2024] [Indexed: 01/23/2024]
Abstract
Food fraud prevention and detection remains a challenging problem, despite recent developments in regulatory and auditing requirements. In 2012, the United States Pharmacopeial Convention created a database of food ingredient fraud. The objective of this research was to report on updates made to the database structure and to provide an updated analysis of food fraud records. The restructured database was relational and included four tables: ingredients, adulterants, adulteration records, and references. Four adulteration record types were created to capture the variety of information that can be found in public food fraud reports. Information was searched and extracted from the peer-reviewed scientific literature, media publications, regulatory reports, judicial records, trade association reports, and other public sources covering 1980-present. Over an almost seven-year data entry period, a total of 15,575 records were entered, sourced primarily from the peer-reviewed literature and media reports. The percentage of records that included at least one potentially hazardous adulterant ranged from 34% to 60%, depending on the record type. The ingredients with the highest number of incident and inference records included fluid cow's milk, extra virgin olive oil, honey, beef, and chili powder. The ingredient groups with the highest number of incident and inference records included Dairy Ingredients, Seafood Products, Meat and Poultry Products, Herbs, Spices, and Seasonings, Milk and Cream, and Alcoholic Beverages. This database was created to serve as a standardized source of information about publicly documented occurrences of food fraud and other information relevant to fraud risk to support food fraud vulnerability assessments, mitigation plans, and food safety plans. These data support the contention that food fraud presents a public health risk that should continue to be addressed by food safety systems worldwide.
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Affiliation(s)
| | - Henry B Chin
- Henry Chin and Associates, 5781 El Dorado Ln., Dublin, CA 94568, USA
| | - Fernando A Lopes
- FoodChain ID, 504 N. 4th Street, Fairfield, IA 52556, USA; Ministério da Agricultura, Pecuária e Abastecimento, R. José Veríssimo, 420 - Tarumã, Curitiba - PR CEP 82820-000, Brazil
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24
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Sarvutiene J, Prentice U, Ramanavicius S, Ramanavicius A. Molecular imprinting technology for biomedical applications. Biotechnol Adv 2024; 71:108318. [PMID: 38266935 DOI: 10.1016/j.biotechadv.2024.108318] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/18/2023] [Revised: 01/14/2024] [Accepted: 01/20/2024] [Indexed: 01/26/2024]
Abstract
Molecularly imprinted polymers (MIPs), a type of biomimetic material, have attracted considerable interest owing to their cost-effectiveness, good physiochemical stability, favourable specificity and selectivity for target analytes, and widely used for various biological applications. It was demonstrated that MIPs with significant selectivity towards protein-based targets could be applied in medicine, diagnostics, proteomics, environmental analysis, sensors, various in vivo and/or in vitro applications, drug delivery systems, etc. This review provides an overview of MIPs dedicated to biomedical applications and insights into perspectives on the application of MIPs in newly emerging areas of biotechnology. Many different protocols applied for the synthesis of MIPs are overviewed in this review. The templates used for molecular imprinting vary from the minor glycosylated glycan-based structures, amino acids, and proteins to whole bacteria, which are also overviewed in this review. Economic, environmental, rapid preparation, stability, and reproducibility have been highlighted as significant advantages of MIPs. Particularly, some specialized MIPs, in addition to molecular recognition properties, can have high catalytic activity, which in some cases could be compared with other bio-catalytic systems. Therefore, such MIPs belong to the class of so-called 'artificial enzymes'. The discussion provided in this manuscript furnishes a comparative analysis of different approaches developed, underlining their relative advantages and disadvantages highlighting trends and possible future directions of MIP technology.
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Affiliation(s)
- Julija Sarvutiene
- Department of Nanotechnology, Center for Physical Sciences and Technology (FTMC), Sauletekio av. 3, Vilnius, Lithuania
| | - Urte Prentice
- Department of Nanotechnology, Center for Physical Sciences and Technology (FTMC), Sauletekio av. 3, Vilnius, Lithuania
| | - Simonas Ramanavicius
- Department of Nanotechnology, Center for Physical Sciences and Technology (FTMC), Sauletekio av. 3, Vilnius, Lithuania
| | - Arunas Ramanavicius
- Department of Nanotechnology, Center for Physical Sciences and Technology (FTMC), Sauletekio av. 3, Vilnius, Lithuania.
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25
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Teng L, Huang L, Zhou H, Wang B, Yue M, Li Y. Microbiological hazards in infant and toddler food in China: A comprehensive study between 2004 and 2022. Food Res Int 2024; 180:114100. [PMID: 38395570 DOI: 10.1016/j.foodres.2024.114100] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/28/2023] [Revised: 01/15/2024] [Accepted: 02/05/2024] [Indexed: 02/25/2024]
Abstract
Infant and toddler food (ITF), including powdered infant and follow-up formula (PIFF) and complementary food (CF), provides the majority of early-life nutrients for young children. As infants and toddlers are more vulnerable to foodborne diseases, the safety concern of ITF is the ultimate priority. However, nationwide surveillance for the presence of hazards, specifically microbiological hazards, in the Chinese ITF is partially known, posing a significant knowledge gap for risk ranking. Most importantly, the related regional surveys were largely published in Chinese, making the data unavailable for global sharing. To bridge these gaps, we screened 5,306 publications and conducted a comprehensive meta-analysis for microbiological hazards using 129 qualified studies. The four most reported microbiological hazards in ITF were Bacillus cereus (13.4 %), Cronobacter (4.8 %), Staphylococcus aureus (1.3 %), and Salmonella (1.1 %). B. cereus is a risk factor in ITF, specifically in PIFF, cereals, and ready-to-eat food. The prevalence of B. cereus was high in Northern and Southern China, while the prevalence of Cronobacter was high in Central China. Cronobacter is a microbiological hazard, specifically in PIFF, with a prevalence of 3.0 %. Interestingly, the prevalence dynamics of Cronobacter and B. cereus in ITF were rising and stable, respectively, whereas the prevalence of S. aureus and Salmonella decreased over time. Together, our analysis will promote the global sharing of these critical findings and may guide future policy making.
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Affiliation(s)
- Lin Teng
- Institute of Preventive Veterinary Sciences & Department of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou 310058, China.
| | - Linlin Huang
- Institute of Preventive Veterinary Sciences & Department of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou 310058, China.
| | - Haiyang Zhou
- Institute of Preventive Veterinary Sciences & Department of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou 310058, China; Hainan Institute of Zhejiang University, Sanya 572025, China.
| | - Baikui Wang
- Institute of Preventive Veterinary Sciences & Department of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou 310058, China.
| | - Min Yue
- Institute of Preventive Veterinary Sciences & Department of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou 310058, China; Hainan Institute of Zhejiang University, Sanya 572025, China; Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Hangzhou 310058, China.
| | - Yan Li
- Institute of Preventive Veterinary Sciences & Department of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou 310058, China; Hainan Institute of Zhejiang University, Sanya 572025, China.
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26
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Djekic I, Smigic N. Consumer Perception of Food Fraud in Serbia and Montenegro. Foods 2023; 13:53. [PMID: 38201081 PMCID: PMC10778550 DOI: 10.3390/foods13010053] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/07/2023] [Revised: 12/06/2023] [Accepted: 12/20/2023] [Indexed: 01/12/2024] Open
Abstract
The main objective of this study was to investigate how food fraud is perceived among consumers in Serbia and Montenegro. A total of 1264 consumers from the two countries participated in an online survey during the second half of 2022, using Google forms®. In the Serbian population, older or highly educated respondents are aware of different types of fraudulent activities such as substitution, mislabeling, concealment, and counterfeiting. Dilution is mostly recognized by women, the younger population, and students. Consumers believe that trust is the most important factor when purchasing food. The highest level of agreement regarding food fraud is that such activities may pose serious health risks to consumers, and that food inspection services are the most responsible actors in the food chain continuum. When it comes to purchasing food, open green markets are most trustworthy, followed by hypermarkets. Concerning the types of food, fish is most susceptible to fraud, followed by olive oil. This study builds upon existing knowledge of food consumers about food fraud in Europe.
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Affiliation(s)
- Ilija Djekic
- Department of Food Safety and Quality Management, Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11080 Belgrade, Serbia;
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27
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Yan H, Neves MDG, Wise BM, Moraes IA, Barbin DF, Siesler HW. The Application of Handheld Near-Infrared Spectroscopy and Raman Spectroscopic Imaging for the Identification and Quality Control of Food Products. Molecules 2023; 28:7891. [PMID: 38067622 PMCID: PMC10708147 DOI: 10.3390/molecules28237891] [Citation(s) in RCA: 5] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/31/2023] [Revised: 11/29/2023] [Accepted: 11/29/2023] [Indexed: 12/18/2023] Open
Abstract
The following investigations describe the potential of handheld NIR spectroscopy and Raman imaging measurements for the identification and authentication of food products. On the one hand, during the last decade, handheld NIR spectroscopy has made the greatest progress among vibrational spectroscopic methods in terms of miniaturization and price/performance ratio, and on the other hand, the Raman spectroscopic imaging method can achieve the best lateral resolution when examining the heterogeneous composition of samples. The utilization of both methods is further enhanced via the combination with chemometric evaluation methods with respect to the detection, identification, and discrimination of illegal counterfeiting of food products. To demonstrate the solution to practical problems with these two spectroscopic techniques, the results of our recent investigations obtained for various industrial processes and customer-relevant product examples have been discussed in this article. Specifically, the monitoring of food extraction processes (e.g., ethanol extraction of clove and water extraction of wolfberry) and the identification of food quality (e.g., differentiation of cocoa nibs and cocoa beans) via handheld NIR spectroscopy, and the detection and quantification of adulterations in powdered dairy products via Raman imaging were outlined in some detail. Although the present work only demonstrates exemplary product and process examples, the applications provide a balanced overview of materials with different physical properties and manufacturing processes in order to be able to derive modified applications for other products or production processes.
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Affiliation(s)
- Hui Yan
- School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212100, China;
| | - Marina D. G. Neves
- Department of Physical Chemistry, University Duisburg-Essen, 45117 Essen, Germany;
| | | | - Ingrid A. Moraes
- Department of Food Engineering and Technology, School of Food Engineering, University of Campinas, Campinas 13083-862, Brazil; (I.A.M.); (D.F.B.)
| | - Douglas F. Barbin
- Department of Food Engineering and Technology, School of Food Engineering, University of Campinas, Campinas 13083-862, Brazil; (I.A.M.); (D.F.B.)
| | - Heinz W. Siesler
- Department of Physical Chemistry, University Duisburg-Essen, 45117 Essen, Germany;
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28
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Okolo CA, Kilcawley KN, O'Connor C. Recent advances in whiskey analysis for authentication, discrimination, and quality control. Compr Rev Food Sci Food Saf 2023; 22:4957-4992. [PMID: 37823807 DOI: 10.1111/1541-4337.13249] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/23/2023] [Revised: 08/29/2023] [Accepted: 09/12/2023] [Indexed: 10/13/2023]
Abstract
In order to safeguard authentic whiskey products from fraudulent or counterfeit practices, high throughput solutions that provide robust, rapid, and reliable solutions are required. The implementation of some analytical strategies is quite challenging or costly in routine analysis. Qualitative screening of whiskey products has been explored, but due to the nonspecificity of the chemical compounds, a more quantitative confirmatory technique is required to validate the result of the whiskey analysis. Hence, combining analytical and chemometric methods has been fundamental in whiskey sample differentiation and classification. A comprehensive update on the most relevant and current analytical techniques, including spectroscopic, chromatographic, and novel technologies employed within the last 5 years in whiskey analysis for authentication, discrimination, and quality control, are presented. Furthermore, the technical challenges in employing these analytical techniques, future trends, and perspectives are emphasized.
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Affiliation(s)
- Chioke A Okolo
- FOCAS Research Institute, Technological University Dublin, Dublin, Ireland
- School of Food Science & Environmental Health, Technological University Dublin, Dublin, Ireland
| | - Kieran N Kilcawley
- Food Quality & Sensory Science Department, Teagasc Food Research Centre, Co Cork, Ireland
- School of Food and Nutritional Sciences, College of Science, Engineering and Food Science, University College Cork, Cork, Ireland
| | - Christine O'Connor
- School of Food Science & Environmental Health, Technological University Dublin, Dublin, Ireland
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29
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Phimmasone S, Boonsri P, Siangproh W, Ratanawimarnwong N, Jittangprasert P, Mantim T, Limchoowong N, Songsrirote K. Carbon dots derived from citric acid and urea as fluorometric probe for determining melamine contamination in infant formula sample. Methods Appl Fluoresc 2023; 12:015003. [PMID: 37647911 DOI: 10.1088/2050-6120/acf547] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/24/2023] [Accepted: 08/30/2023] [Indexed: 09/01/2023]
Abstract
Melamine has been intentionally added into food products to increase the protein count at less cost, especially in dairy products for infant resulting in serious adverse effects on health of consumers. Therefore, this study aimed to develop a method to quantify melamine in dairy products based on the change of fluorescent properties of carbon dots (CDs) as sensing probe. CDs with green-fluorescent emission were synthesized from citric acid and urea under microwave irradiation. The synthesized CDs emitted fluorescence at the maximum wavelength of 538 nm with excitation wavelength of 410 nm. Thus, they provided high sensitivity and selectivity on melamine detection by which fluorescent emission of the CDs was increasingly quenched upon increasing melamine concentrations. Optimal conditions for melamine determination using the CDs was under pH 6, volume ratio between CDs and sample of 2:8 and reaction time of 15 min. The developed method provided high precision of melamine determination with less than 5% of %RSD (n = 5), wide detection range from 1.0 to 200.0 ppm, and high sensitivity with limit of detection (LOD) of 0.47 ppm and limit of quantification (LOQ) of 1.56 ppm, which is within the regulated level by the Food and Drug Administration of the United States for melamine in dairy products. Several analytical characterization techniques were conducted to elucidate the reaction mechanism between CDs and melamine, and the hydrogen bonding interaction was proposed.
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Affiliation(s)
- Souliyanh Phimmasone
- Department of Chemistry, Faculty of Science, Srinakharinwirot University, Sukhumvit 23, Wattana, Bangkok 10110, Thailand
| | - Pornthip Boonsri
- Department of Chemistry, Faculty of Science, Srinakharinwirot University, Sukhumvit 23, Wattana, Bangkok 10110, Thailand
| | - Weena Siangproh
- Department of Chemistry, Faculty of Science, Srinakharinwirot University, Sukhumvit 23, Wattana, Bangkok 10110, Thailand
- Center of Excellence in Agricultural Innovation and Food Safety, Faculty of Science, Srinakharinwirot University, Bangkok, 10110, Thailand
| | - Nuanlaor Ratanawimarnwong
- Department of Chemistry, Faculty of Science, Srinakharinwirot University, Sukhumvit 23, Wattana, Bangkok 10110, Thailand
- Center of Excellence in Agricultural Innovation and Food Safety, Faculty of Science, Srinakharinwirot University, Bangkok, 10110, Thailand
| | - Piyada Jittangprasert
- Department of Chemistry, Faculty of Science, Srinakharinwirot University, Sukhumvit 23, Wattana, Bangkok 10110, Thailand
- Center of Excellence in Agricultural Innovation and Food Safety, Faculty of Science, Srinakharinwirot University, Bangkok, 10110, Thailand
| | - Thitirat Mantim
- Department of Chemistry, Faculty of Science, Srinakharinwirot University, Sukhumvit 23, Wattana, Bangkok 10110, Thailand
- Center of Excellence in Agricultural Innovation and Food Safety, Faculty of Science, Srinakharinwirot University, Bangkok, 10110, Thailand
| | - Nunticha Limchoowong
- Department of Chemistry, Faculty of Science, Srinakharinwirot University, Sukhumvit 23, Wattana, Bangkok 10110, Thailand
- Center of Excellence in Agricultural Innovation and Food Safety, Faculty of Science, Srinakharinwirot University, Bangkok, 10110, Thailand
| | - Kriangsak Songsrirote
- Department of Chemistry, Faculty of Science, Srinakharinwirot University, Sukhumvit 23, Wattana, Bangkok 10110, Thailand
- Center of Excellence in Agricultural Innovation and Food Safety, Faculty of Science, Srinakharinwirot University, Bangkok, 10110, Thailand
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30
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Zhang S, Chen J, Wang Z, Chen C, Chen A, Jing Q, Liu J. Dynamic Source Distribution and Emission Inventory of a Persistent, Mobile, and Toxic (PMT) Substance, Melamine, in China. ENVIRONMENTAL SCIENCE & TECHNOLOGY 2023; 57:14694-14706. [PMID: 37734035 PMCID: PMC11017250 DOI: 10.1021/acs.est.3c02945] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 04/19/2023] [Revised: 08/21/2023] [Accepted: 09/12/2023] [Indexed: 09/23/2023]
Abstract
Persistent, mobile, and toxic (PMT) substances are affecting the safety of drinking water and are threatening the environment and human health. Many PMT substances are used in industrial processing or consumer products, but their sources and emissions mostly remain unclear. This study presents a long-term source distribution and emission estimation of melamine, a high-production-volume PMT substance of emerging global concern. The results indicate that in China, approximately 1858.7 kilotonnes (kt) of melamine were released into the water (∼58.9%), air (∼27.0%), and soil systems (∼14.1%) between 1995 and 2020, mainly from its production and use in the decorative panels, textiles, and paper industries. The textile and paper industries have the highest emission-to-consumption ratios, with more than 90% emissions per unit consumption. Sewage treatment plants are the largest source of melamine in the environment for the time being, but in-use products and their wastes will serve as significant melamine sources in the future. The study prompts priority action to control the risk of PMT substances internationally.
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Affiliation(s)
- Shaoxuan Zhang
- State
Key Joint Laboratory for Environmental Simulation and Pollution Control,
College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China
| | - Jiazhe Chen
- State
Key Joint Laboratory for Environmental Simulation and Pollution Control,
College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China
| | - Zhanyun Wang
- Empa
− Swiss Federal Laboratories for Materials Science and Technology,
Technology and Society Laboratory, 9014 St. Gallen, Switzerland
| | - Chengkang Chen
- State
Key Joint Laboratory for Environmental Simulation and Pollution Control,
College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China
| | - Anna Chen
- State
Key Joint Laboratory for Environmental Simulation and Pollution Control,
College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China
| | - Qiaonan Jing
- State
Key Joint Laboratory for Environmental Simulation and Pollution Control,
College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China
| | - Jianguo Liu
- State
Key Joint Laboratory for Environmental Simulation and Pollution Control,
College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China
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31
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Al-Otaibi JS, Sheena Mary Y, Mary S, Mondal A, Acharjee N. DFT analysis on the adsorption of melamine in Ga 12-N 12/P 12 nanocages: solvent effects, SERS analysis, reactivity properties. J Biomol Struct Dyn 2023; 41:8844-8855. [PMID: 36300533 DOI: 10.1080/07391102.2022.2137700] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/13/2022] [Accepted: 10/14/2022] [Indexed: 10/31/2022]
Abstract
Due to its negative effects on people, melamine contamination in food products are detected and filtered. Amongst several sensory schemes for the screening of melamine poisoning, one of the most promising techniques is the use of nanomaterial based sensing for real time applicability in industries. In the current work, we have looked into the way melamine binds to Ga12-N12/P12 nanocages. Surface-enhanced Raman scattering (SERS), a successful spectroscopic technique is used to monitor melamine. Density functional theoretical (DFT) computations were used to study the sensing properties of melamine (Me) with Ga12-N12/P12 nanocages. Reactivity and Mulliken charge analyses show charge transfer from melamine to nanocage. Me-Ga12-N12 and Me-Ga12P12 clusters have adsorption energies of -47.54 and -33.12 kcal/mol, respectively. All nanocage-Me systems have a significant increase in polarizability. The electron densities revealed non-covalent interactions in the adsorbed systems. All adsorption energies in aqueous media are negative, indicating an attractive and exothermic reaction, with maximum value in water for Me-Ga12N12 and in acetone for Me-Ga12P12. Evidence of SERS is observed due to the enhancement of different vibrational modes.Communicated by Ramaswamy H. Sarma.
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Affiliation(s)
- Jamelah S Al-Otaibi
- Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
| | | | | | - Asmita Mondal
- Department of Chemistry, Durgapur Government College, Paschim Bardhaman, West Bengal, India
| | - Nivedita Acharjee
- Department of Chemistry, Durgapur Government College, Paschim Bardhaman, West Bengal, India
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32
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Erisgin Z, Barak MZ, Usta M, Tekelioglu Y, Turkoglu I, Mutlu HS. Melamine exposure during the weaning period negatively affects ovarian reserve. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH INTERNATIONAL 2023; 30:104805-104813. [PMID: 37707728 DOI: 10.1007/s11356-023-29752-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 05/09/2023] [Accepted: 09/03/2023] [Indexed: 09/15/2023]
Abstract
In this study, it was aimed to investigate the effects of melamine exposure since the weaning period on ovarian tissue and ovarian reserve. Melamine is illegally added to milk and formula to provide high false protein positivity. Female rats (the weaning period = 21 days old, n = 18) were divided into 3 groups. 0.1 mL saline was applied to the control group by gavage for 21 days. Fifty mg/kg and seventy-five mg/kg melamine was dissolved in 0.1 mL of saline and applied by gavage for 21 days, respectively. At the end of the experiment, plasma anti-Mullerian hormone (AMH) was measured, follicle count and ovarian diameter measurement were performed in the right ovaries, and flow cytometric analysis for apoptosis was performed in the left ovaries. While a statistically significant decrease was not observed in the number of the follicle and ovarian diameter between the control and melamine-treated groups (p > 0.05), a significant decrease in the corpus luteum and a significant increase in the number of atretic follicles were observed (p < 0.05). Apoptosis (Annexin V) increased in both melamine groups and AMH plasma level decreased significantly in the 75 mg/kg group (p < 0.05). Melamine exposure from the weaning (early postnatal) period may cause a decrease in ovarian reserve in parallel with a dose increase.
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Affiliation(s)
- Zuleyha Erisgin
- Giresun University Faculty of Medicine Department of Histology and Embryology, Giresun, Türkiye.
| | - Mensure Zuhal Barak
- Faculty of Business, Department of Business Administration, Adana Alparslan Turkes Science and Technology University, Adana, Türkiye
| | - Murat Usta
- Giresun University Faculty of Medicine Department of Medical Biochemistry, Giresun, Türkiye
| | - Yavuz Tekelioglu
- Faculty of Medicine Department of Histology and Embryology, Black Sea Technical University, Trabzon, Türkiye
| | - Ismail Turkoglu
- Giresun University Faculty of Medicine Department of Histology and Embryology, Giresun, Türkiye
| | - Hasan Serdar Mutlu
- Giresun University Faculty of Medicine Department of Histology and Embryology, Giresun, Türkiye
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Limthin D, Leepheng P, Tunhoo B, Onlaor K, Klamchuen A, Phromyothin D, Thiwawong T. Preparation of surface-modified electrode of copper(ii) oxide mixed with the molecularly imprinted polymer for enhancement of melamine detection with photoelectrochemical technique. RSC Adv 2023; 13:14729-14736. [PMID: 37197674 PMCID: PMC10183999 DOI: 10.1039/d3ra01854g] [Citation(s) in RCA: 4] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/21/2023] [Accepted: 04/24/2023] [Indexed: 05/19/2023] Open
Abstract
Melamine contamination in food and beverages affects short- and long-term health. In this work, enhanced sensitivity and selectivity in photoelectrochemical determination for melamine detection was achieved using copper(ii) oxide (CuO) combined with a molecularly imprinted polymer (MIP). A CuO nanomaterial was used to achieve MIP surface modification via co-precipitation synthesis. An MIP film was deposited by polymerizing the methacrylic acid monomer and a melamine template. The properties of the CuO nanomaterials, such as the surface morphology, chemical oxidation state, and crystalline structure, were characterized using field emission scanning electron microscopy (FESEM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction patterns (XRD), respectively. The diffuse reflection spectroscopy technique was applied to evaluate the optical properties of the CuO nanoparticles. The results indicated that the synthesized CuO nanomaterials had a monoclinic structure with an optical bandgap of 1.49 eV, which corresponds to absorbance in the visible light region. CPE electrodes with surface-modified CuO/MIP were measured using the photoelectrochemical techniques of cyclic voltammetry, differential pulse voltammetry (DPV), and amperometry. The modified CuO/MIP electrode for melamine detection in 7.4 pH PBS buffer solution exhibited a high sensitivity of 0.332 nA nM-1, with a linear range of 5.0-75.0 nM and a limit of detection of 2.45 nM. Moreover, real samples of various kinds of milk were applied to evaluate the sensing response of the prepared CuO/MIP electrode. The modified CuO/MIP electrodes could be reused seven times with good reproducibility and high selectivity for melamine detection.
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Affiliation(s)
- Dalawan Limthin
- College of Materials Innovation and Technology, King Mongkut's Institute of Technology Ladkrabang Bangkok 10520 Thailand
| | - Piyawan Leepheng
- College of Materials Innovation and Technology, King Mongkut's Institute of Technology Ladkrabang Bangkok 10520 Thailand
| | - Benchapol Tunhoo
- College of Materials Innovation and Technology, King Mongkut's Institute of Technology Ladkrabang Bangkok 10520 Thailand
- Electronic and Control System for Nanodevice Research Laboratory (ECSN), College of Materials Innovation and Technology, King Mongkut's Institute of Technology Ladkrabang 10520 Thailand
| | - Korakot Onlaor
- College of Materials Innovation and Technology, King Mongkut's Institute of Technology Ladkrabang Bangkok 10520 Thailand
- Electronic and Control System for Nanodevice Research Laboratory (ECSN), College of Materials Innovation and Technology, King Mongkut's Institute of Technology Ladkrabang 10520 Thailand
| | - Annop Klamchuen
- National Nanotechnology Center, National Science and Technology Development Agency Patumthani 12120 Thailand
| | - Darinee Phromyothin
- College of Materials Innovation and Technology, King Mongkut's Institute of Technology Ladkrabang Bangkok 10520 Thailand
| | - Thutiyaporn Thiwawong
- College of Materials Innovation and Technology, King Mongkut's Institute of Technology Ladkrabang Bangkok 10520 Thailand
- Electronic and Control System for Nanodevice Research Laboratory (ECSN), College of Materials Innovation and Technology, King Mongkut's Institute of Technology Ladkrabang 10520 Thailand
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Teerasong S, Boonyaratsewee P, Aunruan P, Saard W, Saetear P. A rapid cotton swab for on-site screening of coloring curcumin on durian skin: food safety aspects. ANAL SCI 2023:10.1007/s44211-023-00349-x. [PMID: 37101098 DOI: 10.1007/s44211-023-00349-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/03/2023] [Accepted: 04/13/2023] [Indexed: 04/28/2023]
Abstract
Exported durians from Thailand are sometimes immersed in curcumin to give the fruits a good appearance. Curcumin is regarded as non-toxic additive, however some importing countries prohibited use of any additive to fresh fruits and vegetables. This work aims to develop a rapid, low cost and convenient cotton swab device for curcumin detection. The detection principle involves a colorimetric acid-base characteristic of curcumin. Curcumin in an acidic/neutral solution presents a bright yellow color, while it displays an intense orange-red color in basic solution. A cotton swab acted for both sample collection and as a sensing platform. A pre-moistened swab was used to wipe a durian surface. Afterward, a NaOH solution was dropped onto the swab. A distinct orange-red color appearing on the swab indicates the presence of curcumin. The cotton swab was applied for qualitative analysis of curcumin contaminated on durian husks via visual detection. The developed device provided good reliability, 93.75% (36 samples). Furthermore, the device was demonstrated for quantitative determination using camera detection. Two linear calibrations were obtained in ranges of 10-75 and 75-250 mg L-1, with a detection limit of 3.2 mg L-1. The method was also successfully applied to quantification of curcumin in durians (three samples) and dietary supplements (two samples). The test can be done in a few minutes. The developed device was established as an useful tool for food safety and control of contamination by curcumin in an on-site application.
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Affiliation(s)
- Saowapak Teerasong
- Department of Chemistry and Applied Analytical Chemistry Research Unit, School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand.
- Flow Innovation-Research for Science and Technology Laboratories (FIRST Labs), Bangkok, Thailand.
| | - Phanaporn Boonyaratsewee
- Department of Chemistry and Applied Analytical Chemistry Research Unit, School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand
| | - Panuwat Aunruan
- Department of Chemistry and Applied Analytical Chemistry Research Unit, School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand
| | - Worawan Saard
- Department of Chemistry and Applied Analytical Chemistry Research Unit, School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand
| | - Phoonthawee Saetear
- Flow Innovation-Research for Science and Technology Laboratories (FIRST Labs), Bangkok, Thailand
- Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand
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Pradhane AP, Methekar RN, Agrawal SG. Investigations on melamine-based uric acid kidney stone formation and its prevention by inhibitors. Urolithiasis 2023; 51:68. [PMID: 37039903 DOI: 10.1007/s00240-023-01437-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/03/2023] [Accepted: 03/25/2023] [Indexed: 04/12/2023]
Abstract
Melamine (Mel) as a milk powder adulterant came to light in September 2008, when a kidney stone disease (KSD) outbreak struck China. The mechanism of the formation of Mel-associated uric acid (UA) stones is relatively unknown. Therefore, in the present study, Mel's influence was explored at comparatively higher and lower concentrations in artificial urine. The parameter optimization performed when the Mel concentration in artificial urine was low, which revealed that higher pH values and lower UA concentration considerably delayed the induction of UA crystallization. When Mel concentration was increased relative to UA concentration, the induction time of UA crystallization decreased dramatically. At the highest concentration of Mel investigated (at UA-Mel molar ratio 1:1), PXRD analysis and SEM revealed a change in crystalline structure of the samples. Based on FTIR analysis, it was determined that UA-Mel interactions are essentially physical, because no new characteristic bands developed. Two inhibitors, namely tri-potassium citrate (TPC) and 3, 7-dimethylxanthine (DMX), were investigated for their inhibitory action on UA crystallization in the presence of Mel. DMX was observed to be more promising than TPC in delaying the induction of crystallisation and hence inhibiting crystal formation.
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Affiliation(s)
- Ashish P Pradhane
- Department of Chemical Engineering, Visvesvaraya National Institute of Technology, Nagpur, 440010, Maharashtra, India
| | - Ravi N Methekar
- Department of Chemical Engineering, Visvesvaraya National Institute of Technology, Nagpur, 440010, Maharashtra, India.
| | - Shailesh G Agrawal
- Department of Chemical Engineering, Visvesvaraya National Institute of Technology, Nagpur, 440010, Maharashtra, India
- Crystallization Design Institute, Molecular Science Research Centre, University of Puerto Rico, 1390 C. Juan Ponce de Léon, San Juan, PR, 00926, USA
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Suliman Maashi M. CRISPR/Cas-based Aptasensor as an Innovative Sensing Approaches for Food Safety Analysis: Recent Progresses and New Horizons. Crit Rev Anal Chem 2023; 54:2599-2617. [PMID: 36940173 DOI: 10.1080/10408347.2023.2188955] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/21/2023]
Abstract
Food safety is one of the greatest public problems occurring around the world. Chemical, physical, and microbiological hazards could lead to food safety problems, which might occur at all stages of the supply chain. To tackle food safety problems and protect consumer health, specific, accurate, and rapid diagnosis techniques meeting various requirements are the imperative measures to ensure food safety. CRISPR-Cas system, a novel emerging technology, is effectively repurposed in (bio)sensing and has shown a tremendous capability to develop on-site and portable diagnostic methods with high specificity and sensitivity. Among numerous existing CRISPR/Cas systems, CRISPR/Cas13a and CRISPR/Cas12a are extensively employed in the design of biosensors, owing to their ability to cleave both non-target and target sequences. However, the specificity limitation in CRISPR/Cas has hindered its progress. Nowadays, nucleic acid aptamers recognized for their specificity and high-affinity characteristics for their analytes are incorporated into CRISPR/Cas systems. With the benefits of reproducibility, high durability, portability, facile operation, and cost-effectiveness, CRISPR/Cas-based aptasensing approaches are an ideal choice for fabricating highly specific point-of-need analytical tools with enhanced response signals. In the current study, we explore some of the most recent progress in the CRISPR/Cas-mediated aptasensors for detecting food risk factors including veterinary drugs, pesticide residues, pathogens, mycotoxins, heavy metals, illegal additives, food additives, and other contaminants. The nanomaterial engineering support with CRISPR/Cas aptasensors is also signified to achieve a hopeful perspective to provide new straightforward test kits toward trace amounts of different contaminants encountered in food samples.
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Affiliation(s)
- Marwah Suliman Maashi
- Medical Laboratory Science Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
- Regenerative Medicine Unit at King Fahad Medical Research Centre, Jeddah, Saudi Arabia
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Pérez-Calabuig AM, Pradana-López S, Lopez-Ortega S, Otero L, Cancilla JC, Torrecilla JS. Residual neural networks to quantify traces of melamine in yogurts through image deconvolution. J Food Compost Anal 2023. [DOI: 10.1016/j.jfca.2023.105197] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/07/2023]
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Hayes E, Greene D, O’Donnell C, O’Shea N, Fenelon MA. Spectroscopic technologies and data fusion: Applications for the dairy industry. Front Nutr 2023; 9:1074688. [PMID: 36712542 PMCID: PMC9875022 DOI: 10.3389/fnut.2022.1074688] [Citation(s) in RCA: 5] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/19/2022] [Accepted: 12/05/2022] [Indexed: 01/12/2023] Open
Abstract
Increasing consumer awareness, scale of manufacture, and demand to ensure safety, quality and sustainability have accelerated the need for rapid, reliable, and accurate analytical techniques for food products. Spectroscopy, coupled with Artificial Intelligence-enabled sensors and chemometric techniques, has led to the fusion of data sources for dairy analytical applications. This article provides an overview of the current spectroscopic technologies used in the dairy industry, with an introduction to data fusion and the associated methodologies used in spectroscopy-based data fusion. The relevance of data fusion in the dairy industry is considered, focusing on its potential to improve predictions for processing traits by chemometric techniques, such as principal component analysis (PCA), partial least squares regression (PLS), and other machine learning algorithms.
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Affiliation(s)
- Elena Hayes
- University College Dublin (UCD) School of Biosystems and Food Engineering, University College Dublin, Dublin, Ireland,Teagasc Food Research Centre, Moorepark, Fermoy, Ireland
| | - Derek Greene
- University College Dublin (UCD) School of Computer Science, University College Dublin, Dublin, Ireland
| | - Colm O’Donnell
- University College Dublin (UCD) School of Biosystems and Food Engineering, University College Dublin, Dublin, Ireland
| | - Norah O’Shea
- Teagasc Food Research Centre, Moorepark, Fermoy, Ireland
| | - Mark A. Fenelon
- University College Dublin (UCD) School of Biosystems and Food Engineering, University College Dublin, Dublin, Ireland,Teagasc Food Research Centre, Moorepark, Fermoy, Ireland,*Correspondence: Mark A. Fenelon,
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Ferraz de Arruda H, Aleta A, Moreno Y. Food composition databases in the era of Big Data: Vegetable oils as a case study. Front Nutr 2023; 9:1052934. [PMID: 36687693 PMCID: PMC9851468 DOI: 10.3389/fnut.2022.1052934] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/24/2022] [Accepted: 12/07/2022] [Indexed: 01/07/2023] Open
Abstract
Understanding the population's dietary patterns and their impacts on health requires many different sources of information. The development of reliable food composition databases is a key step in this pursuit. With them, nutrition and health care professionals can provide better public health advice and guide society toward achieving a better and healthier life. Unfortunately, these databases are full of caveats. Focusing on the specific case of vegetable oils, we analyzed the possible obsolescence of the information and the differences or inconsistencies among databases. We show that in many cases, the information is limited, incompletely documented, old or unreliable. More importantly, despite the many efforts carried out in the last decades, there is still much work to be done. As such, institutions should develop long-standing programs that can ensure the quality of the information on what we eat in the long term. In the face of climate change and complex societal challenges in an interconnected world, the full diversity of the food system needs to be recognized and more efforts should be put toward achieving a data-driven food system.
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Affiliation(s)
- Henrique Ferraz de Arruda
- ISI Foundation, Turin, Italy,CENTAI Institute, Turin, Italy,*Correspondence: Henrique Ferraz de Arruda ✉
| | - Alberto Aleta
- ISI Foundation, Turin, Italy,Institute for Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza, Zaragoza, Spain,Department of Theoretical Physics, Faculty of Sciences, University of Zaragoza, Zaragoza, Spain
| | - Yamir Moreno
- ISI Foundation, Turin, Italy,CENTAI Institute, Turin, Italy,Institute for Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza, Zaragoza, Spain,Department of Theoretical Physics, Faculty of Sciences, University of Zaragoza, Zaragoza, Spain
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40
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Can North American animal poison control center call data provide early warning of outbreaks associated with contaminated pet food? Using the 2007 melamine pet food contamination incident as a case study. PLoS One 2022; 17:e0277100. [PMID: 36480561 PMCID: PMC9731476 DOI: 10.1371/journal.pone.0277100] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/20/2022] [Accepted: 10/19/2022] [Indexed: 12/13/2022] Open
Abstract
The 2007 melamine pet food contamination incident highlighted the need for enhanced reporting of toxicological exposures and development of a national quantitative disease surveillance system for companion animals. Data from poison control centers, such as the Animal Poison Control Center (APCC), may be useful for conducting real-time surveillance in this population. In this study, we explored the suitability of APCC call data for early warning of toxicological incidents in companion animal populations by using a-priori knowledge of the melamine-related nephrotoxicosis outbreak. Patient and household-level information regarding possible toxicological exposures in dogs and cats reported to the APCC from 2005 to 2007, inclusive, were extracted from the APCC's AnTox database. These data were used to examine the impact of surveillance outcome, statistical methodology, analysis level, and call source on the ability to detect the outbreak prior to the voluntary recall issued by the pet food manufacturer. Retrospective Poisson temporal scan tests were applied for each combination of outcome, method, level, and call source. The results showed that month-adjusted scans using syndromic data may have been able to help detect the outbreak up to two months prior to the voluntary recall although the success of these methods varied across call sources. We also demonstrated covariate month-adjustment can lead to vastly different results based on the surveillance outcome and call source to which it is applied. This illustrates care should be taken prior to arbitrarily selecting a surveillance outcome and statistical model for surveillance efforts and warns against ignoring the impacts of call source or key covariates when applying quantitative surveillance methods to APCC call data since these factors can lead to very different results. This study provides further evidence that APCC call data may be useful for conducting surveillance in the US companion animal population and further exploratory analyses and validation studies are warranted.
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Synthesis and Characterisation of Alginate Functionalized Gold Nanoparticles for Melamine Detection. BIONANOSCIENCE 2022. [DOI: 10.1007/s12668-022-01050-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/03/2022]
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Shi XX, Wang F, Wang ZZ, Huang GY, Li M, Simal-Gandara J, Hao GF, Yang GF. Unveiling toxicity profile for food risk components: A manually curated toxicological databank of food-relevant chemicals. Crit Rev Food Sci Nutr 2022; 64:5176-5191. [PMID: 36457196 DOI: 10.1080/10408398.2022.2152423] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/03/2022]
Abstract
Rigorous risk assessment of chemicals in food and feed is essential to address the growing worldwide concerns about food safety. High-quality toxicological data on food-relevant chemicals are fundamental for risk modeling and assessment in the food safety area. The organization and analysis of substantial toxicity information can positively support decision-making by providing insight into toxicity trends. However, it remains challenging to systematically obtain fragmented toxicity data, and related toxicological resources are required to meet the current demands. In this study, we collected 221,439 experimental toxicity records for 5,657 food-relevant chemicals identified from extensive databases and literature, along with their information on chemical identification, physicochemical properties, environmental fates, and biological targets. Based on the aggregated data, a freely available web-based databank, Food-Relevant Available Chemicals Toxicology Databank (FRAC-TD) is presented, which supports multiple browsing ways and search criterions. Applying FRAC-TD for data-driven analysis, we revealed the underlying toxicity profiles of food-relevant chemicals in humans, mammals, and other species in the food chain. Expectantly, FRAC-TD could positively facilitate toxicological studies, toxicity prediction, and risk assessments in the food industry.
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Affiliation(s)
- Xing-Xing Shi
- Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, P. R. China
| | - Fan Wang
- Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, P. R. China
| | - Zhi-Zheng Wang
- Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, P. R. China
| | - Guang-Yi Huang
- Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, P. R. China
| | - Min Li
- Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, P. R. China
| | - Jesus Simal-Gandara
- Analytical Chemistry and Food Science Department, Faculty of Science, Universidade de Vigo, Nutrition and Bromatology Group, Ourense, Spain
| | - Ge-Fei Hao
- Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, P. R. China
- State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Research and Development Center for Fine Chemicals, Guizhou University, Guiyang, Guizhou, P.R. China
| | - Guang-Fu Yang
- Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, P. R. China
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Choi G, Kuiper JR, Bennett DH, Barrett ES, Bastain TM, Breton CV, Chinthakindi S, Dunlop AL, Farzan SF, Herbstman JB, Karagas MR, Marsit CJ, Meeker JD, Morello-Frosch R, O'Connor TG, Pellizzari ED, Romano ME, Sathyanarayana S, Schantz S, Schmidt RJ, Watkins DJ, Zhu H, Kannan K, Buckley JP, Woodruff TJ. Exposure to melamine and its derivatives and aromatic amines among pregnant women in the United States: The ECHO Program. CHEMOSPHERE 2022; 307:135599. [PMID: 36055588 PMCID: PMC9748524 DOI: 10.1016/j.chemosphere.2022.135599] [Citation(s) in RCA: 9] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 01/24/2022] [Revised: 06/24/2022] [Accepted: 07/01/2022] [Indexed: 05/09/2023]
Abstract
BACKGROUND Melamine, melamine derivatives, and aromatic amines are nitrogen-containing compounds with known toxicity and widespread commercial uses. Nevertheless, biomonitoring of these chemicals is lacking, particularly during pregnancy, a period of increased susceptibility to adverse health effects. OBJECTIVES We aimed to measure melamine, melamine derivatives, and aromatic amine exposure in pregnant women across the United States (U.S.) and evaluate associations with participant and urine sample collection characteristics. METHODS We measured 43 analytes, representing 45 chemicals (i.e., melamine, three melamine derivatives, and 41 aromatic amines), in urine from pregnant women in nine diverse ECHO cohorts during 2008-2020 (N = 171). To assess relations with participant and urine sample collection characteristics, we used generalized estimating equations to estimate prevalence ratios (PRs) for analytes dichotomized at the detection limit, % differences (%Δ) for continuous analytes, and 95% confidence intervals. Multivariable models included age, race/ethnicity, marital status, urinary cotinine, and year of sample collection. RESULTS Twelve chemicals were detected in >60% of samples, with near ubiquitous detection of cyanuric acid, melamine, aniline, 4,4'-methylenedianiline, and a composite of o-toluidine and m-toluidine (99-100%). In multivariable adjusted models, most chemicals were associated with higher exposures among Hispanic and non-Hispanic Black participants. For example, concentrations of 3,4-dichloroaniline were higher among Hispanic (%Δ: +149, 95% CI: +17, +431) and non-Hispanic Black (%Δ: +136, 95% CI: +35, +311) women compared with non-Hispanic White women. We observed similar results for ammelide, o-/m-toluidine, 4,4'-methylenedianiline, and 4-chloroaniline. Most chemicals were positively associated with urinary cotinine, with strongest associations observed for o-/m-toluidine (%Δ: +23; 95% CI: +16, +31) and 3,4-dichloroaniline (%Δ: +25; 95% CI: +17, +33). Some chemicals exhibited annual trends (e.g., %Δ in melamine per year: -11; 95% CI: -19, -1) or time of day, seasonal, and geographic variability. DISCUSSION Exposure to melamine, cyanuric acid, and some aromatic amines was ubiquitous in this first investigation of these analytes in pregnant women. Future research should expand biomonitoring, identify sources of exposure disparities by race/ethnicity, and evaluate potential adverse health effects.
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Affiliation(s)
- Giehae Choi
- Department of Environmental Health and Engineering, Johns Hopkins University, Baltimore, MD, USA
| | - Jordan R Kuiper
- Department of Environmental Health and Engineering, Johns Hopkins University, Baltimore, MD, USA
| | - Deborah H Bennett
- Department of Public Health Sciences, University of California Davis, Davis, CA, USA
| | - Emily S Barrett
- Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA
| | - Theresa M Bastain
- Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA
| | - Carrie V Breton
- Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA
| | - Sridhar Chinthakindi
- Department of Pediatrics and Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
| | - Anne L Dunlop
- Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA
| | - Shohreh F Farzan
- Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA
| | - Julie B Herbstman
- Department of Environmental Health Sciences, Columbia University, New York, NY, USA
| | - Margaret R Karagas
- Department of Epidemiology, Dartmouth Geisel School of Medicine, Lebanon, NH, USA
| | - Carmen J Marsit
- Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA
| | - John D Meeker
- Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA
| | - Rachel Morello-Frosch
- Department of Environmental Science, Policy and Management and School of Public Health, University of California, Berkeley, CA, USA
| | - Thomas G O'Connor
- Department of Psychiatry, University of Rochester, Rochester, NY, USA
| | | | - Megan E Romano
- Department of Epidemiology, Dartmouth Geisel School of Medicine, Lebanon, NH, USA
| | - Sheela Sathyanarayana
- Department of Pediatrics, University of Washington, Seattle Children's Research Institute, Seattle, WA, USA; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
| | - Susan Schantz
- Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, USA
| | - Rebecca J Schmidt
- Department of Public Health Sciences, University of California Davis, Davis, CA, USA
| | - Deborah J Watkins
- Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA
| | - Hongkai Zhu
- Department of Pediatrics and Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
| | - Kurunthachalam Kannan
- Department of Pediatrics and Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
| | - Jessie P Buckley
- Department of Environmental Health and Engineering, Johns Hopkins University, Baltimore, MD, USA
| | - Tracey J Woodruff
- Department of Obstetrics, Gynecology, and Reproductive Sciences and the Philip R. Lee Institute for Health Policy Studies, University of California San Francisco, San Francisco, CA, USA.
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Liu J, Wu D, Chen J, Jia S, Chen J, Wu Y, Li G. CRISPR-Cas systems mediated biosensing and applications in food safety detection. Crit Rev Food Sci Nutr 2022; 64:2960-2985. [PMID: 36218189 DOI: 10.1080/10408398.2022.2128300] [Citation(s) in RCA: 12] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/03/2022]
Abstract
Food safety, closely related to economic development of food industry and public health, has become a global concern and gained increasing attention worldwide. Effective detection technology is of great importance to guarantee food safety. Although several classical detection methods have been developed, they have some limitations in portability, selectivity, and sensitivity. The emerging CRISPR-Cas systems, uniquely integrating target recognition specificity, signal transduction, and efficient signal amplification abilities, possess superior specificity and sensitivity, showing huge potential to address aforementioned challenges and develop next-generation techniques for food safety detection. In this review, we focus on recent progress of CRISPR-Cas mediated biosensing and their applications in food safety monitoring. The properties and principles of commonly used CRISPR-Cas systems are highlighted. Notably, the frequently coupled nucleic acid amplification strategies to enhance their selectivity and sensitivity, especially isothermal amplification methods, as well as various signal output modes are also systematically summarized. Meanwhile, the application of CRISPR-Cas systems-based biosensors in food safety detection including foodborne virus, foodborne bacteria, food fraud, genetically modified organisms (GMOs), toxins, heavy metal ions, antibiotic residues, and pesticide residues is comprehensively described. Furthermore, the current challenges and future prospects in this field are tentatively discussed.
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Affiliation(s)
- Jianghua Liu
- School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, China
| | - Di Wu
- Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast, UK
| | - Jiahui Chen
- School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, China
| | - Shijie Jia
- School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, China
| | - Jian Chen
- School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, China
| | - Yongning Wu
- School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, China
- NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing, China
| | - Guoliang Li
- School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, China
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45
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Das A, Chadha R, Chalke B, Maiti N. Gold nanoparticle based colorimetric and Raman “turn-off” sensing of melamine in milk. Colloids Surf A Physicochem Eng Asp 2022. [DOI: 10.1016/j.colsurfa.2022.129717] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/25/2022]
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46
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Zhang J, Wu HC, Chen L, Su Y. Effect of social media use on food safety risk perception through risk characteristics: Exploring a moderated mediation model among people with different levels of science literacy. Front Psychol 2022; 13:963863. [PMID: 36248473 PMCID: PMC9562472 DOI: 10.3389/fpsyg.2022.963863] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/08/2022] [Accepted: 08/29/2022] [Indexed: 11/13/2022] Open
Abstract
Food safety risk (FSR) is becoming a vital issue for public health, and improving public awareness of FSR through social media is necessary. This study aims to explore specific mechanisms of FSR perception; it first categorizes 19 risk characteristics into two variables, dread and efficacy, and then examines how social media use affects perceived FSR through both variables. Additionally, the study explores the moderating effects of source credibility and science literacy on the mechanisms of FSR perception. Based on a nationwide online survey (N = 2,015) of more than six salient food safety issues in China, the study found that exposure to food safety risk information on social media can help improve perceived FSR based on the proposed “dread–efficacy processing model” (DEPM), where dread stimulates perceived risk, while efficacy suppresses risk perception. Moreover, source credibility intensifies the effect of social media use on efficacy appraisal, whereas science literacy exerts a “double-weakening” influence on dread appraisal. Theoretical and practical implications of the findings are discussed.
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Affiliation(s)
- Jie Zhang
- Center for Internet and Governance Research of Sun Yat-sen University, Guangzhou, China
| | - Hsi-Chen Wu
- School of Journalism and Communication, Tsinghua University, Beijing, China
| | - Liang Chen
- School of Journalism and Communication, Tsinghua University, Beijing, China
- *Correspondence: Liang Chen,
| | - Youzhen Su
- Department of Communication Arts and Sciences, The Pennsylvania State University, State College, PA, United States
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47
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Bhandari SD, Gallegos-Peretz T, Wheat T, Jaudzems G, Kouznetsova N, Petrova K, Shah D, Hengst D, Vacha E, Lu W, Moore JC, Metra P, Xie Z. Amino Acid Fingerprinting of Authentic Nonfat Dry Milk and Skim Milk Powder and Effects of Spiking with Selected Potential Adulterants. Foods 2022; 11:foods11182868. [PMID: 36140996 PMCID: PMC9498471 DOI: 10.3390/foods11182868] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/15/2022] [Revised: 08/17/2022] [Accepted: 09/02/2022] [Indexed: 11/27/2022] Open
Abstract
A collaborative study was undertaken in which five international laboratories participated to determine amino acid fingerprints in 39 authentic nonfat dry milk (NFDM)/skim milk powder (SMP) samples. A rapid method of amino acid analysis involving microwave-assisted hydrolysis followed by ultra-high performance liquid chromatography-ultraviolet detection (UHPLC-UV) was used for quantitation of amino acids and to calculate their distribution. The performance of this rapid method of analysis was evaluated and was used to determine the amino acid fingerprint of authentic milk powders. The distribution of different amino acids and their predictable upper and lower tolerance limits in authentic NFDM/SMP samples were established as a reference. Amino acid fingerprints of NFDM/SMP were compared with selected proteins and nitrogen rich compounds (proteins from pea, soy, rice, wheat, whey, and fish gelatin) which can be potential economically motivated adulterants (EMA). The amino acid fingerprints of NFDM/SMP were found to be affected by spiking with pea, soy, rice, whey, fish gelatin and arginine among the investigated adulterants but not by wheat protein and melamine. The study results establish an amino acid fingerprint of authentic NFDM/SMP and demonstrate the utility of this method as a tool in verifying the authenticity of milk powders and detecting their adulteration.
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Affiliation(s)
- Sneh D. Bhandari
- Merieux NutriSciences, 3600 Eagle Nest Drive, Crete, IL 60417, USA
| | | | - Thomas Wheat
- Waters Corporation, 34 Maple Street, Milford, MA 01757, USA
| | - Gregory Jaudzems
- Nestlé Quality Assurance Center, 6625 Eiterman Rd., Dublin, OH 43017, USA
| | - Natalia Kouznetsova
- United States Pharmacopeia (USP), 12601 Twinbrook Parkway, Rockville, MD 20852, USA
| | - Katya Petrova
- United States Pharmacopeia (USP), 12601 Twinbrook Parkway, Rockville, MD 20852, USA
| | - Dimple Shah
- Waters Corporation, 34 Maple Street, Milford, MA 01757, USA
| | - Daniel Hengst
- Eurofins Food Integrity and Innovation, Madison, WI 53704, USA
| | - Erika Vacha
- Eurofins Food Integrity and Innovation, Madison, WI 53704, USA
| | - Weiying Lu
- Institute of Food and Nutraceutical Science, Department of Food Science and Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
| | - Jeffrey C. Moore
- United States Pharmacopeia (USP), 12601 Twinbrook Parkway, Rockville, MD 20852, USA
| | - Pierre Metra
- Merieux NutriSciences Corporation, 113 Route de Paris, 69160 Tassin la Demi-Lune, France
| | - Zhuohong Xie
- United States Pharmacopeia (USP), 12601 Twinbrook Parkway, Rockville, MD 20852, USA
- Correspondence: ; Tel.: +1-240-221-2052
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48
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Wang Z, Wu Q, Kamruzzaman M. Portable NIR spectroscopy and PLS based variable selection for adulteration detection in quinoa flour. Food Control 2022. [DOI: 10.1016/j.foodcont.2022.108970] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/25/2022]
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49
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Osei Tutu B, Laryea EB, Asante R, Darko DA. Evaluation of surveillance system for post market activities on pre-packaged foods in Greater Accra Region, Ghana, 2021. PUBLIC HEALTH IN PRACTICE 2022; 4:100292. [PMID: 36570390 PMCID: PMC9773048 DOI: 10.1016/j.puhip.2022.100292] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/17/2022] [Revised: 06/27/2022] [Accepted: 07/06/2022] [Indexed: 12/27/2022] Open
Abstract
Objectives This evaluation was to assess the usefulness and attributes of the surveillance system for post market activities on pre-packaged foods in the Greater Accra Region of Ghana and also to determine if the systems objectives are being met. Methods A descriptive cross-sectional design was used for the evaluation. Data/records on Food Market Surveillance collected between 2018 and 2020 was reviewed and key stakeholders involved in the Food Market Surveillance interviewed using a semi-structured questionnaire. Surveillance operations were also observed. Quantitative data was analyzed using descriptive summary statistics. Information gathered from interviews were put under themes. Result Some policy decision taken were based on analysis of data from the surveillance system. The system is useful in detecting trends signaling changes on label of registered prepackage food products. The system can permit assessment of the compliance of levels of importers/manufacturers; however, such analysis was not done. The system involves single step notification and processing steps and can incorporate data from other systems. Some retailers perceived the system as a hindrance to business. Completion of notification forms takes 2-5 min and 1-5 working days to process and take regulatory action. The surveillance system had a data accuracy and completeness of 94.6% (194/205) and 94.1% (193/205) respectively with less than 0.1% (3/95) double entries. The system did not have any data validation process or team in place. Conclusion The system was partially meeting its intended objectives and found useful despite some gaps and challenges observed. The system is simple, flexible, accepted by most of the stakeholders and covers almost the entire districts in the Greater Accra Region. We recommend that data validation process or team be instituted to ensure reliability of data generated for policy and regulatory decisions.
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Affiliation(s)
- Benjamin Osei Tutu
- Food and Drugs Authority, Accra, Ghana,Ghana Field Epidemiology and Laboratory Training Programme (GFELTP), Department of Epidemiology and Disease Control, School of Public Health, University of Ghana, Legon, Accra, Ghana,Corresponding author. Food and Drugs Authority, Accra, Ghana.
| | - Eunice Baiden Laryea
- Ghana Field Epidemiology and Laboratory Training Programme (GFELTP), Department of Epidemiology and Disease Control, School of Public Health, University of Ghana, Legon, Accra, Ghana
| | - Rita Asante
- Food and Drugs Authority, Accra, Ghana,Ghana Field Epidemiology and Laboratory Training Programme (GFELTP), Department of Epidemiology and Disease Control, School of Public Health, University of Ghana, Legon, Accra, Ghana
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50
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Food fraud in insecure times: challenges and opportunities for reducing food fraud in Africa. Trends Food Sci Technol 2022. [DOI: 10.1016/j.tifs.2022.04.017] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/23/2022]
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